Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"interferon-γ"”.
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CHIC2 and STUB1 regulate interferon-γ receptor cell surface expression
… duration and intensity of substrate signaling. Interferon-γ (IFN-γ), a critical antiviral cytokine, transduces its signal through the interferon-γ receptor (IFNGR), a single-pass heterodimeric receptor composed of IFNGR1 and IFNGR2. While the IFN-γ signal transduction pathway is well studied, …
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Interferon-γ aptamers for the diagnosis of extra-pulmonary tuberculosis
… challenging because of the low bacillary burden. Interferon gamma (IFN-γ) has been identified as a promising biomarker for the diagnosis of EPTB. The development of rapid and accurate point-of-care (POC) diagnostic technologies becomes crucial in controlling EPTB. Aptamers referred to as …
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The Balance of Interferon-γ and Interleukin-10 during Influenza A Virus Infection Complicated by Methicillin-Resistant Staphylococcus aureus Superinfection
… transcriptome alterations prompted by interferon (IFN)-γ. Transgenic mouse studies demonstrate that IFN-γ receptor (IFN-γR) signaling in mononuclear phagocytes induces tumor necrosis factor (TNF)-α hyperproduction and lethal inflammatory lung damage, with no detectable benefit to viral …
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In Vivo Genetic Screening to Identify Mechanisms of Resistance to Cancer Immunotherapy
… loss of function of genes required for sensing interferon-γ caused resistance to immunotherapy, which was caused by failure to present antigen and a resistance to the growth inhibiting effect of interferon-γ. Deletion of Ptpn2, a pleotropic protein tyrosine phosphatase, improved response to …
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Astrocytes down-regulate microglial inflammatory responses
… reduced iNOS, COX-2, TNF-alpha, and IL-6 in interferon-γ (IFN-γ)-activated microglia. However, OGD-ACM collected from dead astrocytes at 24 h after the treatment did not reduce IFN-γ-induced iNOS expression. OGD-ACM inhibited microglial activation via direct suppression of IFN-γ-signaling …
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Variable Tnf-α Production By Murine Macrophages to a Cell Wall Extract of Candida Albicans
… manner. Preincubation with 100 U/ml interferon-γ (IFN-γ for 3 h4 pimed macrophages for enhanced TNF-α production. This data indicated that both PMφ and AMφ responded to the combination of IFN-γ and mannan with production of significantly different amounts of TNF-α. While the results …
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Investigation of the cancer testis antigen lactate dehydrogenase C as a CD8 T cell target
… all possible epitopes of the LDHC protein by interferon-γ ELISpot. With this approach, T cell clones from one of five patients were identified that were reactive to minimal peptides contained within LDHC. In this patient, the antigenic LDHC peptide differentiated from LDHA by a single amino …
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The Impact of Cardiorespiratory Fitness on Cytotoxic T Cell Function and Metabolism
… CD8+ T cells (Tc). Tc utilize cytokines, such as interferon-γ (IFN-γ), to orchestrate cell mediated responses to viral infections and tumors (1). Production of cytokines is energy and resource intensive, necessitating sufficient energy and amino acid production to support these processes, …
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Biologinės terapijos taikymas pacientams, sergantiems autoimuniniais artritais /
… BD. Low agreement of tuberculin skin test and interferon-γ release assay for diagnosing latent tuberculosis (TB) before initiation of BD were found. During treatment with BD the highest active TB incidence was detected in patients treated with adalimumab, lowest – in patients with infliximab. …
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Biologic therapy in patients with autoimmune arthritis /
… BD. Low agreement of tuberculin skin test and interferon-γ release assay for diagnosing latent tuberculosis (TB) before initiation of BD were found. During treatment with BD the highest active TB incidence was detected in patients treated with adalimumab, lowest – in patients with infliximab. …
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Impaired Control of Chronic Herpesvirus Infection in Tissue Resident Macrophages During Coinfection with Intestinal Parasite and Other Cell-intrinsic Herpesvirus Interactions
… We found that IL-4 signaling in combination with interferon-γ blockade reactivates MHV68 from latently infected macrophages, but not B cells. We continued our work on cell-specific reactivation signals by examining MHV68 infection in tissue resident peritoneal macrophages, called large peritoneal …
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Inactivation of the JAK-STAT Pathway
… mechanisms of downregulation. After interferon-γ (IFN-γ) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal within 20-30 minutes, remained for 2-2.5 hours and activated molecules disappeared by 4 hours. In the absence of continued signaling …
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Endotoxin-induced microRNA expression in equine peripheral blood mononuclear cells
… controls from 2 hours, while interleukin-10 and interferon-γ were increased at 8 hours. miR-155 expression was correlated to all three cytokines. These data provide a foundation for future research into miRNA involvement in equine inflammatory responses. miR-155 is the principal LPS-induced miRNA …
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Suppression of intestinal inflammation and inflammation-driven colon cancer in mice by dietary sphingomyelin: Importance of peroxisome proliferator-activated receptor γ expression
… an up-regulation in genes involved in Th1 (interferon γ) and Th17 (interleukin [IL]-17 and IL-23) responses despite the reduced inflammation. However, the genes involved in Th2 (IL-4, IL-13 and IL-13ra2) and Treg (IL-10rb) anti-inflammatory responses were up-regulated in a PPAR-γ-dependent …
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The detection and role of human endogenous retroviruses in multiple sclerosis and other neurological diseases
… in these cell lines, but stimulation with interferon-γ, a proinflammatory cytokine, did not alter expression significantly. An antibody against an epitope of MSRV gag has been successfully developed, purified and tested to determine the expression of a predicted linear epitope. This epitope …
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Elucidation of Mechanisms of Host Immunity against Orientia tsutsugamushi in a Newly Developed Murine Model
… significantly greater than those in WT mice. Interferon-γ (IFN-γ) and granzyme B mRNA levels in the liver of CD8-/- and MHC I-/- mice were significantly greater than in WT mice. In addition, more severe histopathologic lesions were observed in CD8-/- mice. Finally, adoptive transfer confirmed …
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Characterisation of physiological and immune-related biomarkers of weaning stress in beef cattle
… numbers, reduced in vitro production of interferon-gamma and increased concentrations of acute phase proteins compared with deferring housing for 35 days post weaning. In cows, transitory neutrophilia (increase in neutrophil number) and lymphopenia (decrease in lymphocyte number), reduced …
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Suppressive Effects of Transforming Factor-β and Interleukin-10 on the Cytolytic Activity of Murine Macrophages and Reversal by Cytokines
… of the immunosuppressive effect by IL-4 and interferon-γ (IFN-γ) were investigated. The responsiveness of naive and peptone-activated macrophages was compared. The cytolytic activity for tumor cells of these effector cells was measured by percent lysis of <sup>3</sup>H-thymidine labeled …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… IL-4 and IL-13, thereby suppressing anti-tumour interferon-γ (IFNγ), Th1 and CD8+ T cell-mediated immunity. Notably, therapeutic blockade of IL-25-signalling decreased tumour ILC2s, MDSCs and cancer burden, while enhancing anti-tumour IFNγ and adaptive T cell immunity. Overall, the IL-25-ILC2 …
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