Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"interferon-α"”.
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Impact of Genetic Variants in Inosine Triphosphate Pyrophosphatase and Interferon-λ4 on Natural History, Treatment Response and Ribavirin Pharmacology in Hepatitis C Virus Infection
… The treatment until 2013 has been based on interferon-α and ribavirin, but is now replaced by direct acting antivirals. Ribavirin is still used in the most difficult-to cure patients. This thesis evaluates host genetic variations in inosine triphosphate pyrophosphatase (ITPA) and …
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Yellow Fever: Role of Heterologous Flavivirus Immunity on Urban Emergence
… of transmission potential. Next, we utilized an interferon α/β receptor knock-out mouse model to determine the role of pre-existing DENV-2 and ZIKV immunity in YF virus infection, and to determine mechanisms of cross-protection. We utilized African and Brazilian YF strains and found that DENV-2 …
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Inhibition of Urothelial Carcinoma By Type I Interferon Activation of The Innate and Adaptive Immune Response
… progression following BCG treatment. Type I interferon (IFN-I) has potent anti-tumor effects against urothelial carcinoma (UC) and may be an alternative treatment option for patients who do not respond to BCG standard of care. However, the mechanisms that mediate the IFN-I-stimulated immune …
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Structural and Biochemical Characterization of N-Terminal Protease of Classical Swine Fever Virus
… the host’s innate immune response by targeting interferon regulatory factor-3 (IRF3) for proteasomal degradation, and thus preventing the transcriptional activation of interferon-α/β genes. We determined the crystal structure of wild type Npro and that of a cleavage site mutant (Npro-C168A) to …
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Determining the Pathogenesis and Enzootic Transmission of Usutu Virus
… 2003, Uganda 2012, and South Africa 1959, in an interferon α/β receptor knockout (Ifnar-/-) mouse model. We observed significant mortality, high viral levels in serum and tissues in all USUV strains except for the Netherlands 2016 strain. Eighteen non-synonymous mutations were identified …
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IDENTIFICATION OF FACTORS INVOLVED IN DOUBLE STRANDED RNA-INDUCED CELL DEATH THROUGH GENOME-WIDE CRISPR SCREENS
… stimulus we used the combination of pI:C, and Interferon-α (IFN-α), which upregulates OAS enzymes thus maximizing the efficiency of dsRNA sensing in IFN-saturating condition. RNASEL-KO cells were, as expected, refractory to IFN-α+pI:C induced cell death; interestingly however, interfering with …
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Roles of Interferon Lambda on Hepatitis B Virus Replication
… is a major cause of liver disease. Only interferon-α (IFN-α) and the nucleosidic inhibitors of the viral polymerase, lamivudine and adefovir, are approved for therapy. However, these therapies are limited by the side effects of interferon and by the substantial resistance of the virus to …
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An Update on Pharmaceutical Strategies for Oral Delivery of Therapeutic Peptides and Proteins
… and among them only 2 are given orally which is Interferon-α and Human growth hormone. Currently, most efforts in both industry and academia are centered around enhancing bioavailability of orally administered TPPs which typically are less than 1%. Oral administration is the non-invasive, most …
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Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
… T cell help but was reduced in the absence of interferon-α/β: IFNα/β) or IFNγ signaling; Batf3-/- mice lacking CD8α+ dendritic cells: DCs) also showed reduced cross-priming. We examined the ability of draining lymph node: dLN) DCs to process and cross-present soluble HEL to CD8+ T cell …
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Ribonuclease H2, RNA:DNA hybrids and innate immunity
… of high levels of the antiviral cytokine interferon-α in the cerebrospinal fluid and blood, which is thought to be produced as a consequence of the activation of the innate immunity by unprocessed self-nucleic acids. This thesis therefore aimed to define the role of one of the AGS …
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Immune parameters as predictors of response to maintenance therapy in low grade non-Hodgkin's lymphoma patients
… received either oral cyclophosphamide or alpha-interferon (α-IFN) as maintenance treatment for a period of two years. The ability to predict patients' treatment response at diagnosis would be extremely helpful for both the patient and the clinician. This would enable appropriate therapy to be …
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Novel insights in the serodiagnosis and pathogenesis of swine influenza
… te beschrijven en het nagaan van de rol van interferon- (IFN-) in de pathogenese van varkensinfluenza. In een tweede deel van het onderzoek werd de bruikbaarheid onderzocht van commercieel beschikbare enzyme-linked immunosorbent assays (ELISA) voor de serologische diagnose van infecties met …