Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"interferon stimulated genes"”.
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Discovery of Unique Antiviral Pathways in a Bat Viral Reservoir, the Black Flying Fox
… use to control viral infections is the interferon response. Upon viral infection, cells produce interferon which inhibits viral infection through downstream effectors called interferon stimulated genes. I questioned whether bat interferon stimulated genes contained unique properties that …
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Disruption of Dna Polymerase Zeta Promotes An Innate Immune Response
… <p><em>Rev3l </em>knockout MEFs had over 1000 genes that were either upregulated or downregulated more than 4-fold. Importantly, this revealed that loss of <em>Rev3l</em>induced an increase in expression of known interferon-stimulated genes indicating that the innate immune system may be …
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Identification and Characterization of Interferon-Stimulated Regulators of Bacterial Infection
The type I interferon activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes as a model bacterial pathogen, I sought to identify the roles of …
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The regulation and function of viperin during rhinovirus infection
… molecules, including pro-inflammatory cytokines, interferons and interferon stimulated genes. Viperin is one of the most highly upregulated interferon stimulated genes in rhinovirus infected airway epithelial cells. Viperin expression during viral infection has long been associated with direct …
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Regulating Inflammation Through Exercise-Mediated Trained Immunity or Genetic Manipulation of the Interferon Locus
… targeting key immune modulatory factors, such as interferons. In my thesis, I employed both approaches. First, we explored whether exercise training could induce adaptations in bone marrow-derived macrophages, resulting in trained immunity, known to occur in immune cells due to persistent …
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An examination of the role of IFI16 in detecting viral DNA in human immortalised keratinocytes
… the endoplasmic reticulum adapter STimulator of INterferon Genes (STING). Activated STING initiates transcription of the anti-viral cytokine interferon-b, and by extension, induces activation of the anti-viral immune response. Other DNA sensors have been proposed to recognise exogenous DNA via …
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Characterizing 3D epigenomes in pathological conditions
… epigenome disturbances is the compromising of interferon-stimulated genes and an increase of proinflammatory genes, paralleling a rise in H3K4me3 modifications at the promoters of pro-inflammatory genes. This investigation not only characterizes the impact of SARS-CoV-2 acute infection on host …
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The Role of Interleukin-10 Family Members in Inflammatory Skin Diseases. Understanding the mechanism of action of interferon lambda and interleukin-22 on human primary keratinocytes and dermal fibroblasts with a focus on healing responses in inflammatory skin diseases
… permanent scars depending on the subtype. Interferons (IFNs), including the skin specific IFNλ mainly activate STAT1, which results in inflammation in CLE and may play a significant role in scar formation in chronic discoid CLE. IL-22 activates STAT3 and it is emerging as a mediator with …
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INNATE IMMUNITY IN ENCEPHALITIC BUNYAVIRUS INFECTION: OVERCOMING NEURONAL VULNERABILITY
… Innate immunity, including the antiviral interferon (IFN) and inflammatory NF-κB pathways, coordinates host responses to pathogens. It is unclear whether neurons are able to detect RVFV and LACV and mount an effective antiviral response, as neurons have likely adapted to minimize …
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MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
… underlying epithelial cells produce interferons upon virus detection that promote the establishment of a local antiviral state through autocrine and paracrine signaling. However, despite these protective measures, IAV continues to cause significant annual morbidity and mortality …
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Characterization of the anti-type I interferon effects of the cellular flice-like inhibitory protein (CFLIP)
… regulation and more recently, modulation of interferon responses. Interferon alpha (IFNa) and interferon beta (IFNb) are in the class of type I IFN and are critical as the first line of defense against viral infection. Interestingly, these IFNs also maintain roles apart from viral infection …
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ESTABLISHING AN IN VITRO MODEL FOR CRISPR-CAS9 SCREENING OF INTERFERON EFFECTORS IN HBV INFECTION
… therapies (World Health Organization 2025). Interferon-alpha (IFN- α), including its pegylated forms, is approved for CHB treatment, but its efficacy is limited to a small subset of patients, and its mechanism of action remains poorly understood. Indeed, interferon therapy can activate …
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The Role of Interferon Stimlated Genes in Resistance and Immunity to Hepatitis C Virus Infection
… The only approved treatment for HCV infection is interferon-alpha based therapy, resulting in viral clearance in approximately fifty percent of patients treated. Interferon therapy mimics endogenous type I interferon signaling, which plays a crucial role in the innate antiviral response through …
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Investigating Interferon-Inducible Antiviral Effectors Through a Virological and Evolutionary Lens
Interferons control viral infection by inducing expression of effector proteins encoded by interferon-stimulated genes (ISGs). The field has focused on identifying antiviral ISG effectors and defining their mechanisms of action. However, fundamental gaps in knowledge about the interferon response …
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The Mechanism of Double-Stranded RNA Response in Neurospora
… and animals. In addition, dsRNA can trigger the interferon response as part of the immune response in vertebrates. In this study, we show that the production of dsRNA triggers the transcriptional induction of qde-2 (an Argonaute gene) and dcl-2 (a Dicer gene), two central components of the RNAi …
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Characterization of the Antiviral Effector IFI6
… against invading pathogens. The production of interferon (IFN) and the subsequent expression of interferon stimulated genes (ISGs) are major contributors to the innate immune response, which establish an antiviral state in the cell. Flaviviruses such as dengue virus, Zika virus, and West Nile …
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Effects of Preovulatory Estradiol Concentration on Embryo Survival and Pregnancy Establishment in Beef Cows
… ECP treated cows compared to CON. Expression of interferon stimulated genes (ISG) was used as a marker for pregnancy on d 17, 19, 21, and 28 and pregnancy-specific protein B (PSPB) was used as a marker for pregnancy on d 22-28. Transrectal ultrasonography was used on d 29 to diagnose pregnancy. …
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BETACORONAVIRUSES OPTIMIZE REPLICATION BY BALANCING ANTAGONISM OF INNATE IMMUNE RESPONSES AND ER STRESS RESPONSES
… within the ER, which limits the induction of interferon stimulated genes during infection. MERS-CoV and HCoV-OC43, conversely, did not antagonize IRE1α, perhaps due to their ability to antagonize interferon signaling itself. Lastly, we found that all viruses induce ER stress responses, …
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Biological Functions of Intracellular Hepatitis B e Antigen
… but not the secreted HBeAg significantly reduced interferon stimulated response element (ISRE) activity and expression of interferon stimulated genes (ISGs) upon interferon-alpha (IFN- α) stimulation. Furthermore, in line with this, RNA-seq analysis of ISG induction profile from IFN-α treated …
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Gene Expression Changes in Immune Cells During Human Immunodeficiency Virus 1 (HIV-1) Infection
… late, showed patterns characteristic of type I interferon (IFN) exposure. We next examined experimentally the possible proximal causes of the observed transcriptional profiles. We analyzed the gene expression patterns induced by TGFβ, 13 type I interferons, as well as recombinant HIV Tat …
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