Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"interferon signaling"”.
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Understanding The Role of Arglu1 In Interferon Signaling Activation In Breast Cancer
… ICB therapy in breast cancer treatment, IFN signaling induction is a potential approach. Our results demonstrated that depletion of several RNA-binding proteins, particularly a poorly known ARGLU1, triggered type I interferon signaling in breast cancer cells. This phenomenon was also seen in …
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Stat3 Inhibits Type I Interferon Signaling In Type I Conventional Dendritic Cells
… 3 (STAT3) mediates the intracellular signaling of interleukin 10 (IL-10), an immunosuppressive cytokine. Therefore, we hypothesized that STAT3 and IL-10 inhibit cDC1 function and induction of T cell-mediated immunity. Herein, we show that IL-10 inhibits polyinosinic:polycytidylic acid …
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Deletions in SARS-CoV-2 nsp6 enhance antagonism of type-I interferon signaling
… of replication organelles, antagonism of interferon type I (IFN-I) responses, and NLRP3 inflammasome activation, a major factor of severe COVID-19. Here, I review the most recent published findings regarding the multiple roles of nsp6 in promoting SARS-CoV-2 replication and investigate …
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Contributions of type 17 immunity and type I interferon signaling to Salmonella-induced autoimmunity
… sequelae remain unclear, type 17 and type I interferon (IFN) signaling play significant roles in the pathogenesis of many classical autoimmune diseases and bacterial infections. Previous research from our lab has shown that Salmonella biofilm-associated amyloid protein, curli, is a potent …
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Identification of an Interferon Signaling Pathway Linking Membrane Cholesterol Accessibility to Host Defense Against Pathogens
Interferon-γ (IFN-γ) is a multipotent cytokine that is critical to the host innate immune defense against bacterial infection, and functions through transcriptional induction of hundreds of IFN-γ stimulated genes (γ-ISGs). However, the antibacterial roles of many γ-ISGs remain poorly defined. Here, …
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Type I Interferon Signaling Pathway May Be Involved in Optimal Interleukin-2 Production in CD4+ T Cells
Previous studies demonstrate that interferon alpha (IFN-α) promotes human T helper 1 memory development by positively regulating interleukin-2 (IL-2) expression, a hallmark cytokine of central memory CD4⁺ T cells. The present work seeks to delineate how signaling through the interferon alpha/beta …
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THE ROLE OF SELECTIVE MRNA DEADENYLATION IN THE HOMEOSTATIC CONTROL OF INNATE IMMUNE SIGNALING
… inflammatory conditions including autoimmunity. Interferon signaling is the specific antiviral arm of the innate immune system responsible for inducing interferons and downstream signaling to control viral infection. While much is known about the stimuli-dependent induction of interferons, less …
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POST-EXPOSURE TREATMENT OF MARBURG VIRUS ANGOLA DISEASE IN NON-HUMAN PRIMATES USING RECOMBINANT VESICULAR STOMATITIS VIRUS VECTORS
… and genes mapping to antiviral responses and interferon signaling. In contrast, animals that succumbed had T helper 2 and regulatory T cell signatures; upregulation of genes associated with T-cell exhaustion; and delayed interferon signaling. Only survivor macaques formed MARV GP-specific IgM …
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Identifying Endogenous Drivers of Chronic Disease Using Novel Computational Methods
… We show that TEs are broadly activated by NF-κB signaling. CS can be activated by sustained interferon signaling. We showed that expressed TEs sustain interferon signaling. We also show that important mediators of CS are coexpressed with TEs in multiple contexts. This work sets the stage for …
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Cooperative Tumor Suppression by ARF and p53
… setting lead to the activation of a type I interferon response driven by interferon-beta and the STAT1 transcription factor. I further demonstrated that ARF and p53 cooperate to suppress the interferon response, and when both proteins are inactivated, interferon signaling can drive tumor …
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Decoding Breast Cancer Development Through Single Cell and Spatial Genomics
… DCIS lesions. Notably, only lipo-macrophages and interferon T cells infiltrated DCIS regions, as well as the formation of tertiary lymphoid structures adjacent to lesions. Furthermore, DCIS cancer cells showed upregulated cell cycling and interferon signaling programs, while reducing cell …
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TISSUE ARCHITECTURE AND INTERCELLULAR COMMUNICATION: MEDIATORS OF PROTECTIVE OR PATHOGENIC INTERFERON RESPONSES
… and thus advanced our ability to evaluate interferon responses using in-vitro systems that closely model in-vivo settings. My thesis work highlights the delicate balance of interferon signaling to avoid unwarranted responses that can be detrimental to the host. My work revealed that these …
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Investigating The Rare Aneuploid Cells in Normal Breast and Therapeutic Resistance in Triple Negative Breast Cancer Using Single Cell Genomics
… subtypes and cancer cell metaprograms for interferon signaling, HLA expression and cell cycle activity that were associated with chemotherapy response.</p>
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Using machine learning to increase the predictive value of humanized mouse models for the human immune response to YFV-17D
… detecting pathogens, innate immune response, and interferon signaling. TRIM22 and TRIM5, and potentially related genes, may be reliably uncovered by semi-supervised ML models applied to humanized mouse models, though further study is required for verification. Overall, modified humanized models, …
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BIOCHEMICAL CHARACTERIZATION OF SUPPRESSOR OF IKK-ε AND NAK-ASSOCIATED PROTEIN 1
… and signals subsequent production of type-I interferon. The TLR3:interferon signaling cascades contains a kinase complex composed of two kinases and a scaffold protein, NAK-associated protein 1 (NAP1). The role of NAP1 in modulating kinase activation or regulation is unknown. A key inhibitory …
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MUCIN-MEDIATED AND INTERFERON-DRIVEN DEFENSE MECHANISMS AGAINST INFLUENZA VIRUS INFECTION IN HUMAN AIRWAY EPITHELIUM
… underlying epithelial cells produce interferons upon virus detection that promote the establishment of a local antiviral state through autocrine and paracrine signaling. However, despite these protective measures, IAV continues to cause significant annual morbidity and mortality …
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Protective or Problematic? Investigating the role of the innate immune receptor NLRX1 as a tumor suppressor or promoter in breast and pancreatic cancer
The innate immune system houses cellular signaling proteins called pattern recognition receptors (PRRs) that are responsible for recognizing highly-conserved molecular patterns associated with pathogens or damage to elicit an immune response. However, NLRX1 is a unique PRR in the NOD-like receptor …
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Precision Medicine Approach to Improving Reconstructive Surgery Outcomes for Breast Cancer Survivors
… was then performed which highlights IL4/13 signaling, extracellular matrix organization, antigen presentation, and interferon signaling as importantly dysregulated pathways. These RNA results were also compared to various clinical and histological measurements to evaluate novel correlations. …
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The Role of Interferon Stimlated Genes in Resistance and Immunity to Hepatitis C Virus Infection
… The only approved treatment for HCV infection is interferon-alpha based therapy, resulting in viral clearance in approximately fifty percent of patients treated. Interferon therapy mimics endogenous type I interferon signaling, which plays a crucial role in the innate antiviral response through …
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