Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"interferon response"”.
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The role of the type-I interferon response in the aggregation of tau protein
… prominent neuroinflammation. The innate immune response, the first line of defence against foreign pathogens, is emerging as a major contributor to the development of neurodegenerative disease. IFN-Is are soluble cytokines produced in the innate immune response which induce an antiviral …
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Hepatitis C Virus NS5A Targets the Nucleosome Assembly Protein NAP1L1 to Control the Interferon Response
… replication/assembly and in the cell antiviral response to HCV. Interaction of NS5A with the nucleosome assembly protein NAP1L1 has been recently characterized in my laboratory. NAP1L1 is a histone chaperone protein with various functions related to nuclear chromatin remodelling that impact on …
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THE ACTIVATION, RECEPTOR COMPLEXING AND ENDOGENOUS REGULATION OF THE TYPE-I INTERFERON RESPONSE AS IT PERTAINS TO INNATE IMMUNITY
… multi-cellular organisms mount an immune response that recognizes, sequesters and eradicates invading infectious agents. Critical to this safeguard is the receptor-mediated detection of pathogens. Pathogen recognition then initiates a variety of signaling cascades that lead to the …
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Regulation of the HCMV UL98 Promoter by Cooperation of the Cyclic AMP Response Element and Gamma Interferon Response Element
… assays to assess changes in promoter activity in response to viral or virally induced proteins.</p> <p>Analysis of promoter activation indicated that the UL98 promoter required the presence of the IE72 and 1E86 immediate early (IE) proteins. In comparison to a prototypical early promoter which …
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Identification of therapeutic targets and dependencies in ZNF703-amplified breast cancer
… regulator of DNA double strand break repair and interferon signalling. Furthermore, ZNF703 overexpression favours error-free repair of CRISPR-Cas9-induced double strand breaks and confers increased dependency on homologous recombination. Interactomic and transcriptomic profiling suggests ZNF703 …
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Investigating Interferon-Inducible Antiviral Effectors Through a Virological and Evolutionary Lens
Interferons control viral infection by inducing expression of effector proteins encoded by interferon-stimulated genes (ISGs). The field has focused on identifying antiviral ISG effectors and defining their mechanisms of action. However, fundamental gaps in knowledge about the interferon response …
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Molecular insights into modulation of host innate immune response by viral proteins of RNA viruses SARS-CoV, HCV and Influenza virus
… counter virus infection is production of type I interferon (IFN), an innate immune response that generates antiviral state to prevent virus replication and spread by expressing several IFN-stimulated genes. Type I interferon response depends on a set of germ-line encoded receptors called pattern …
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A single-cell perspective on infection
… characterized by high expression of the Type I Interferon response after infection. Upon further investigation we found that this heterogeneity in the host Type I Interferon response was the result of heterogeneity in the population of infecting bacteria, namely in the extent of PhoPQ-mediated …
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Mechanisms of Macrophage Detection and Control of Mycobacterium tuberculosis Infection
… by the production of a robust type I interferon response dependent on the activation of a cytosolic surveillance pathway by the recognition of M. tuberculosis DNA in the cytosol. The DNA sensor recognizing M. tuberculosis DNA and initiating activation of the cytosolic surveillance …
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Human Cellular Genetics of Innate Immunity
The type I interferon response is a key part of the innate immune system, responding to infection and inducing an antiviral intracellular state. While there is known to be variability in this signalling pathway between individuals, alongside cell-to-cell heterogeneity in a genetically identical …
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The Effects of TET2-Deficiency on Neutrophil Gene Expression and Function
… (p=0.004). Genes related to motility, the interferon response, and neutrophil development were dysregulated in Tet2-deficient murine neutrophils. Overall, the results suggest that Tet2-deficiency affects neutrophil gene expression and function. Discussion: This study addresses a gap in the …
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Human Neural Stem Cell-Derived Neuron/Astrocyte Co-Cultures as a Model System to Study Emerging Encephalitic Viruses
… signaling defects that may impact cellular responses to infection. This study describes the establishment of a human neural stem cell derived neuron/astrocyte co-cultures system as a model to study encephalitic virus infection. This system provides a more physiologically relevant model that …
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Cooperative Tumor Suppression by ARF and p53
… cells against numerous biological stresses. In response to oncogenic signals, increased ARF expression leads to the activation of p53, which in turn leads to the cessation of cell division or induction of an apoptotic response. Interestingly, p53 coordinates repression of Arf transcription, …
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TRIM22/Staf50 - a novel target gene of the tumor suppressor p53
… of TRIM22 is largely unknown apart from being an interferon inducible protein and its involvement in inhibiting virus infection. TRIM22 belongs to the family of TRIM proteins (RBCC proteins) consisting of a RING finger, a B-box, a coiled-coil and a variable C-terminal. The TRIM proteins have been …
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A-to-I RNA Editing in Human Cells
… RNA molecules to regulate cellular responses to endogenous and exogenous RNA. Of the three ADAR homologs in humans, dysregulation of ADAR1 editing due to inherited mutations leads to disorders such as Aicardi-Goutieres syndrome, an inflammatory disease that manifests in the brain and …
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Combinatorial lipid-like materials for intracellular delivery of small RNAs that activate innate antiviral immune responses and adjuvant vaccines
… same siRNA can also activate an innate immune response. Recognition of RNA by specialized immune cells occurs through pattern recognition receptors, which have evolved to respond to RNA viruses, such as the Toll-like receptors (TLR) 7 and 8 located in the endosome of dendritic cells. Tailoring …
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Discovery of Unique Antiviral Pathways in a Bat Viral Reservoir, the Black Flying Fox
… use to control viral infections is the interferon response. Upon viral infection, cells produce interferon which inhibits viral infection through downstream effectors called interferon stimulated genes. I questioned whether bat interferon stimulated genes contained unique properties that …
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Development of an inducible psoriasis-like in vivo model
… in this model. In addition, in this model, interferon response genes are downregulated, which contrasts with human psoriasis. However this downregulation is partially reversed following treatment with WP1066 as measured by the expression of IFI27, suggesting that activation of STAT3 is at …
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Molecular biology of segment 8 of the influenza A virus genome
… many cellular anti-viral pathways, such as the interferon response. Prior to this work, a proteomics study found that influenza A virus infection induces the re-localisation of cellular protein ADAR1 to the nucleolus. ADAR1 is an RNA-editing enzyme that converts adenosine residues to inosines, …
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Identification and Characterization of Interferon-Stimulated Regulators of Bacterial Infection
The type I interferon activated transcriptional response is a critical antiviral defense mechanism, yet its role in bacterial pathogenesis remains less well characterized. Using an intracellular pathogen Listeria monocytogenes as a model bacterial pathogen, I sought to identify the roles of …
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