Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 147 for “"interferon gamma"”.
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Equine interferon-gamma and associated cytokines
… this effect we have initiated studies on equine interferon-gamma and related cytokines and obtained the following results. Equine interferon-gamma was cloned and produced in a variety of heterologous protein-expression systems. The biological activity of recombinant equine interferon-gamma was …
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Interferon-gamma hemmt die Replikation des Hepatitis-C-Virus
… C entwickeln, lieferten Hinweise darauf, dass Interferon(IFN)-gamma womöglich eine entscheidende Rolle dabei zukommt. Um eine antivirale Wirkung von IFN-gamma von einer immunmodulatorischen abzugrenzen, habe ich den Effekt von IFN-gamma auf die Protein- und RNA-Synthese von HCV mit Hilfe von …
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Molecular Dissection of Interferon-Gamma Treated Pancreatic Beta-Cells
Conclusions. Interferon-$\gamma,$ but not IFN-$\alpha,$ has a direct pathogenic role on the pancreatic $\beta$-cell. Early expression of IFN-$\alpha$ by the $\beta$-cell may contribute to insulitis whereas IFN-$\gamma,$ a product of islet infiltrating leukocytes, may mediate characteristic …
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Somatolactogenic hormones and interferon-gamma as regulators of neutrophil activation
… as well as the classic phagocyte activator, interferon-gamma (IFN-$\gamma$), in activating polymorphonulear neutrophils (PMN) from pigs, cows, rats and humans to kill Escherichia coli and secrete superoxide anion (O$\sb2\sp-$) after stimulation with phorbol myristate acetate (PMA). GH, as …
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
Inflammatory cytokines are closely related to melanogenesis in melanocytes. Here, I studied whether IFN-γ affects melanogenesis, and if so, what is the underlying mechanism involved in it. Using B16 melanoma cell lines and primary human melanocytes, I demonstrated that alpha-MSH induced tyrosinase …
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The Role of Interferon Gamma in the Stroma of Growing and Regressing Tumours
… und der Charakterisierung der Rolle von Interferon gamma (IFNg) in der Abstoßung von Tumoren durch geringe Konzentrationen von Cyclophosphamide (Cy). Diese Arbeit zeigt, daß haematopoetische Zellen IFN-g produzieren, welches für die Abstoßung von Tumoren notwendig ist. Mit Hilfe des …
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Characterization and improvement of interferon-[gamma] glycosylation in Chinese hamster ovary cell culture
… (i.e., Asn25 and Asn97) of recombinant human interferon-[gamma]y (IFNY-[gamma]) derived from Chinese hamster ovary (CHO) cell culture were characterized by a sensitive (- 1 [mu]) and rapid (- 3 h) analytical methodology employing a variety of tandem chromatographic techniques, capillary …
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Evasion of interferon-gamma responses by Toxoplasma gondii in murine and human fibroblasts
… a chronic infection and ensure transmission. Interferon-gamma (IFNγ) activation of non-immune cells is crucial for host defense against Toxoplasma. In murine cells, interferon-inducible immune-related GTPases (IRGs) are essential to the IFN[gamma] response because they disrupt the …
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Diagnóstico de la infección tuberculosa latente mediante IGRA (interferon gamma release assays) en Asturias
Los ensayos basados en la liberación de IFN-γ (IGRA) detectan la respuesta de los linfocitos T frente a los antígenos ESAT-6 y CFP-10 que expresa M. tuberculosis y están ausentes en M bovis BCG y en la mayoría de las micobacterias ambientales. Existen dos técnicas comerciales: QuantiFERON®-TB Gold …
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Characterization of the effects of Interferon gamma protein-10 (CXCL10) against the protozoan parasite Leishmania amazonesis
Leishmania amazonensis causes progressive disease in most inbred strains of mice. We have previously shown that L. amazonensis-infected C57BL/6 mice have profound impairments in expression of pro-inflammatory cytokines, chemokines and in activation of antigen-specific CD4+ T cells. These …
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Die Bedeutung von Interferon alpha und Interferon gamma auf den Verlauf der Marekschen Krankheit beim Haushuhn
… between host and virus needs to be expanded. Interferons are cytokines with antiviral activity. On the basis of their structural and functional features they can be divided into type I (IFN-alpha and IFN-beta) and type II (IFN-gamma) interferons. Type I plays an important role during the early …
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Defining the functional response of Mycobacterium sp. infected macrophages to structural variants of Interferon gamma (IFN-y)
Interferon-gamma (IFN-γ) is a key cytokine that orchestrates immune defence through its antiviral, antimicrobial, and antitumour activities. Despite its central role in immune regulation, its broader therapeutic application has been constrained by an incomplete understanding of how subtle …
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Estrogen Regulates Interferon-gamma (IFN-g) and IFN-g-Inducible iNOS Gene Expression: Implications to Immunity and Autoimmunity
It is now clear that estrogen not only modulates the differentiation and function of reproductive systems, but it also profoundly regulates the immune system of normal and autoimmune individuals. An important mechanism by which estrogen regulates the immune system is by altering the secretion …
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The macrophage activating properties of growth hormone in vitro and in vivo: Comparison to interferon-gamma (IF N-gamma)
… capacity of activated M$\Phi$. To date, Interferon-$\gamma$ (IFN-$\gamma$), a classically defined macrophage activating factor (MAF), has been the most completely characterized substance both in vitro and in vivo known to be produced by mammalian cells that augments the production of …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
… of tobacco smoke. Published data show the use of interferons (IFNs) in the treatment of lung tumours due to their potential in displaying antiproliferative, anti-angiogenic, immunoregulatory, and proapoptotic effects. Type1 IFNs have been employed as treatments for many types of cancer, both for …
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Applying a new technique, the interferon gamma liposomal delivery system to improve drug delivery in the treatment of Lung Cancer
… of tobacco smoke. Published data show the use of interferons (IFNs) in the treatment of lung tumours due to their potential in displaying antiproliferative, anti-angiogenic, immunoregulatory, and proapoptotic effects. Type1 IFNs have been employed as treatments for many types of cancer, both for …
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A Novel Mechanism of Skin Tumor Promotion Involving Interferon-Gamma (Ifnγ)/Signal Transducer and Activator of Transcription-1 (Stat1) Signaling In Epidermis
… treatment with CHRY but not TPA upregulated interferon-gamma (IFNg) mRNA in the epidermis and that the induction of both IRF-1 and uStat1 was dependent on IFNg signaling. Stat1 deficient (Stat1<sup>-/-</sup>) mice were highly resistant to skin tumor promotion by CHRY. In contrast, the tumor …
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Regulation of CD74 expression in response to Human Interferon Gamma and Lipopolysaccharide on Human Trophoblast Derived Cells: Relevance for Human Feto-Maternal Tolerance.
During pregnancy, the maternal immune system protects the allogeneic foetus from rejection. At the same time the mother maintains immunity defences against potential pathogens. This study aimed to identify whether immunological receptors associated with antigen presentation and strong inflammatory …
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The neonatal anti-viral response fails to control measles virus spread in neurons despite interferon-gamma expression and a Th1-like cytokine profile
… of the brain.</p> <p>The role of interferon-gamma (IFNg), a key anti-viral cytokine in controlling adult CNS infections, was explored during a neuronally-restricted MV infection in the neonatal brain. We hypothesized that neonatal mice would be deficient in either IFNg production …
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The Role of Interferon Gamma in the Regulation of IL-18 Binding Protein and the Development of Autoimmune Arthritis in a Genetically Non-Susceptible Mouse Strain
<p>The etiology of the autoimmune disease rheumatoid arthritis (RA) is unknown, but the role of cytokines, including IFN-g, as effectors of immune cell function has been established by the examination of cytokine production in RA patients and through the use of animal models. C57BL/6 (B6) mice that …
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