Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"interferon alpha/beta"”.
-
Inflammatory Cytokine Mediated CNS Damage: Insights Into the Effects of Tnf-Alpha From a Neuronal Cell Line
… conditions in the CNS. Tumor necrosis factor-$\alpha$ (TNF) is an inflammatory cytokine that has been identified in directing neuronal response to disease or injury. Results are conflicting as to the role of TNF in mediating neuronal injury. TNF can protect neurons from excitotoxic and metabolic …
-
Type I Interferon Signaling Pathway May Be Involved in Optimal Interleukin-2 Production in CD4+ T Cells
Previous studies demonstrate that interferon alpha (IFN-α) promotes human T helper 1 memory development by positively regulating interleukin-2 (IL-2) expression, a hallmark cytokine of central memory CD4⁺ T cells. The present work seeks to delineate how signaling through the interferon alpha/beta …
-
Modeling colorectal cancer initiation using human iPSC-derived intestinal organoids
… identified key pathways, including EGFR-STAT2, interferon alpha/beta signaling activation, and anti-apoptotic signaling upon EGFR induction; KRAS-CDX2 regulation and epithelial homeostasis dysregulation upon KRAS induction; and CTNNB1 to KRAS regulation upon CTNNB1 induction. Some of these …
-
West Nile virus vaccination protects against Usutu virus disease in mice
… Two in vivo models were used: CD-1 mice and interferon alpha-beta receptor 1 deficient (Ifnar1-/-) mice. We discovered that sera from mice vaccinated with D2/WN-V3 neutralized both WNV and USUV in vitro. In the Ifnar1-/- model, we observed that vaccinated mice had higher survival rates and …
-
Dendritic Cells Mediate the Dual Effects of IFN alpha/beta in HCV Immunity
… T cell response. Furthermore, treatment with interferon (IFN)α achieves sustained virologic response in approximately 50% of chronically infected individuals. Conventional dendritic cells (cDCs), as the most potent antigen presenting cells, and plasmacytoid DCs (pDCs), as the principal IFNα/β …