Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"intercellular signaling"”.
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Understanding Intercellular Signaling During Lung Injury-Repair
… virus-infected lung tissue, we uncovered a signaling relationship between alveolar type 1 (AT1) cells and capillary endothelial cells. We also applied our interactome to a hyperoxia model for bronchopulmonary dysplasia, another injury model affecting a majority of lung cell types. In concert …
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Microfluidic platforms for studying cell behavior
Neutrophil chemotaxis and intercellular signaling via diffusible molecules are vital physiological processes in the human body. The two processes play a role in diseases and disorders such as rheumatoid arthritis, tumorigenesis, and sepsis. A better understanding of the two processes will aid in …
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Functional Peptidomics: Combining Discovery-Based Mass Spectrometry and Neurophysiology to Explore Communication of Phase -Resetting Cues in the Rat Suprachiasmatic Nucleus
… as a useful approach to understanding intercellular signaling mechanisms regulating SCN clock phase. Directly detecting dynamic release properties of peptides from the SCN brain slice provides new insights on a complex phenomenon phenomenon. The identification and characterization of …
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Localized HB-EGF signaling and Connexin43 decrease in the myocardium
Growth factor signaling can affect tissue remodeling through autocrine and paracrine mechanisms. Recent evidence indicates that hypertrophic signaling in cardiomyocytes is induced through transactivation of the epidermal growth factor (EGF) receptor by heparin-binding EGF (HB-EGF). Here it is shown …
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Cell-cell and cell-medium interactions in the growth of mouse embryonic stem cells
… builds on previous studies of the role of intercellular signaling in the specification of various cell types in the developing embryo. However, relatively little work has been done on understanding the role of cell-cell communication in the self-renewal of ESCs. In the first part of this …
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Developmental and tissue transcriptional profiles of peptidoglycan recognition proteins in the mosquito Aedes aegypti
… with pathogens like bacteria and can result in intercellular signaling leading to melanization, phagocytosis, or a cascade of antimicrobial peptides that can cause pathogen destruction in a mosquito. PGRP transcript levels in the mosquito Aedes aegypti were measured for five AePGRPs in various …
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Thewingless Signaling Pathway Specifies Fates in the Drosophila Embryonic CNS
… Wnt-1/Wingless (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the wingless …
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The wingless signaling pathway specifies fates in the Drosophila embryonic CNS
… Wnt-1/Wingless (Wg) functions as an intercellular signaling molecule in many developmental processes. Studies in Drosophila have revealed that wg encodes positional necessary to regulate segmental identity during embryogenesis. This thesis examines the function of the wingless …
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FROM MICRONUCLEI TO EMT: MOLECULAR MECHANISMS OF GENOMIC INSTABILITY AND CELLULAR PLASTICITY
… analysis, cellular migration assays, and intercellular signaling studies, my work demonstrates how aneuploidy influences cellular plasticity and activates key pathways such as NF-κB and TGF-β. Notably, this study emphasizes the influence of aneuploid cells on the plasticity of neighboring …
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Design Of A Polysaccharide Derived Tissue Engineered Vascular Graft
… in close proximity to one another to enable intercellular signaling which facilitates cell adhesion, migration and differentiation.</p> <p>Our long-term objective is to fabricate a polysaccharide based vascular graft based on the use of chitosan, for the development of a large vascular graft …
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Neurochemical characterization of the rodent primary sensory system
… within the nervous system. One particular set of intercellular signaling molecules, neuropeptides, are known to play an important role in the transmission of pain and itch signals from the peripheral system to the spinal cord. While we have a basic understanding of how many of these molecules are …
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Enzyme mediated labeling of synaptic proteins for proteomics and imaging
… neuroscience. It is the junction through which signaling occurs between neurons that in aggregate, mediates complex physiological brain function. At a molecular level, this is the site where neurotransmitters are released and recognized, and where remodeling of its protein components occurs to …
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Engineering Organoids for Stem Cell Maturation
… the in vivo hepatic microenvironment. Intra- and intercellular signaling between human hepatic cells in the organoid result in mature iHLCs that exhibit several markers and functions of PHHs within one to two weeks in culture. When two other hepatic cell types, Kupffer cells and liver sinusoidal …
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Investigating the role of nuclear transport proteins secreted by cancer cells
… space have been reported to play a role in intercellular signaling that may have an impact on the biology of the cell type of origin or on cells of different origin, referred to as autocrine or paracrine respectively. This study is aimed at investigating the effect of Kpnb1 bound to enhanced …
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Glia-mediated mechanisms of HIV-1-gp120-induced Synaptic Degeneration
… results indicate that the neuron-to-microglia intercellular FKN/CX3CR1 signaling is critical for gp120-induced synaptic degeneration. To elucidate the molecular mechanism that controls this intercellular signaling, we tested the role of the Wnt3a/β-catenin pathway in regulating FKN expression. …
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Signal transmission in epithelial layers
Cell signaling is at the basis of many biological processes such as development, tissue repair, and homeostasis. It can be carried out by different mechanisms. Here we are focusing on ligand mediated cell-to-cell signaling in which a molecule (ligand) is free to move into the extra-cellular medium. …
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Foundational platform for mammalian synthetic biology
… constructing and optimizing the performance of signaling pathways, the development of a large mammalian genetic part and circuit library, and the characterization and implementation of novel genetic parts and components aimed at developing a foundation for mammalian synthetic biology. I have …
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Regulation of Lung Mesenchymal Cells By Epithelial Wnt Ligands
… neighboring structures and are integral to intercellular signaling. Despite such importance, mesenchymal cells are poorly defined morphologically and molecularly. Their signaling regulation is not well understood, lagging their counterparts in the epithelial, endothelial, and immune …
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An in vitro investigation of the molecular effects of aging and exercise signaling within human skeletal muscle cells
… biogenesis and whether general exercise signaling via the β-2 adrenergic receptor (β2AR) could rescue the dysregulated signaling resulting from aging. Human SKM myoblasts underwent an in vitro continued passaging protocol to represent aging in vivo. Formoterol (FORM), an exercise mimetic, …
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Space radiation-induced bystander signaling in 2D and 3D skin tissue models
… was to investigate bystander effects due to signaling between different cell types cultured within 2D and 3D tissue architectures. 2D bystander signaling was investigated using a transwell insert system in which normal human fibroblasts (A) and keratinocytes (K) were irradiated with 1 GeV/n …
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