Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"intercellular interactions"”.
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Methods for the structural modification and characterization of bacterial glycans
… provided valuable insight into intermolecular interactions, biosynthetic and metabolic pathways, and intercellular interactions. The successful application of metabolic incorporation probes to bacteria has been hampered by their unfastidious use of monosaccharides for energy production. In this …
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Macrophage-mediated resistance mechanisms against MAPK inhibitory by cancer therapeutics
… understanding the full influence of complex intercellular interactions on drug resistance remains a challenge. Here, we combine computation with experiment to investigate the cellular and molecular contributions of the tumor microenvironment to MAPK inhibitor response. First, we employ a …
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Combined experimental and modeling studies reveal new mechanisms in T cell antigen recognition
… in active heterodimerization of CD8 and TCR via intercellular interactions. These results indicate that the binding kinetics of the TCR and associated molecules are not static as previously considered and actively change to enhance recognition. The implications for future research on the TCR and …
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Characterization of CEACAM1 Spatial Distribution, Self-association and Dynamics using High-resolution Microscopy Techniques
… glycoproteins involved in homo- and heterophilic intercellular interactions that control cellular growth, differentiation, tumourigenesis, inflammation and infection. There is growing evidence that CEACAM1 isoforms regulate the cellular response to CEACAM1-mediated interactions between various …
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Deciphering and modelling the action of immune cells using highly multiplexed imaging and deep learning techniques
… response. Understanding the mechanisms by which intercellular interactions exert precise control over the immune system is a crucial step in elucidating the manner in which the immune system behaves during infection, health, or chronic disease. Multiplexed imaging is a beneficial tool that is …
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Haplotype-Specific Effects of the Slam/Cd2 Family on the Immune Response
… These immunoregulatory receptors play a role in intercellular interactions and regulate function in several immune cell lineages. Of the seven family members within the locus, Ly108 appears to be the strongest candidate as B6.Sle1b shows a differential expression in isoforms. Ly108-1 is highly …
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Phosphatase Regulation of Mechanical Stress and Aging in C. elegans
… environment from organism. Age impairs intercellular interactions and the cells' capacity to tightly associate within tissues and form an effective barrier necessary for normal systemic function. In particular, the actin cytoskeleton represents a key determinant in maintaining tissue …
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A three-dimensional agent-based model of glioblastoma with applications towards in vitro and in vivo therapy simulation
… governing cell proliferation, migration, and intercellular interactions between cancer cells and cytotoxic T cells. The model was parameterized using data from a genetically engineered mouse model of proneural and mesenchymal glioblastomas. First, we modeled tumor development in both subtypes …
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Single-cell technologies for monitoring interactions between immune cells
Immune cells participate in dynamic cellular interactions that play a critical role in the defense against pathogens and the destruction of malignant cells. The vast heterogeneity of immune cells motivates the study of these interactions at the single-cell level. In this thesis, we present new …
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Molecular Dynamics Simulations for the Study of Biophysical Processes on Biological Membranes
… the cellular level, including cell protection, intercellular interactions, trans-membrane transport, cell morphology, and protein function, to name a few. The properties of phospholipid bilayers are thus of great interest from both experimental and theoretical standpoints. Although experiments …
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Hybrid Brain-Tissue Based Model to Study the Role of Infiltrating Monocytes in Late Stage Huntington's Disease
… the mechanisms underlying these multicellular interactions remain to be determined, it is possible that such an increase in phagocytosis could lead to the observation of fewer healthy MSNs as quantified in the second set of experiments. </p><p>Together, these three sets of experiments support …
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Examining Cellular Interactions and Response to Chemotherapy in The Glioblastoma Perivascular Niche
Glioblastoma multiforme (GBM) is the most deadly and common form of brain cancer and is responsible for over 50% of adult brain tumors. A specific region within the GBM environment is known as the perivascular niche (PVN). We have designed a 3D in vitro model of the PVN comprised of either collagen …
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Common Alleles of the SLAM/CD2 Family are Associated with Murine Lupus
… members of this family play important roles in intercellular interactions, activation, and function, by engaging in homophilic interactions with themselves or with each other, on a wide variety of immune cell types. Sequence analyses of their extracellular ligand-binding immunoglobulin (Ig) …
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Propagation of engineered cellular properties to colony scales in bacterial populations
… cells is generated by the propagation of local intercellular interactions to larger scales. Understanding this process is one of the fundamental challenges in biology and presents an opportunity to engineer the organization of biological matter. The work described in this thesis has developed a …
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Astrocytic Sonic Hedgehog signalling in development and disease
… in the postnatal brain, where it regulates intercellular communication among neurons, astrocytes, and microglia, and defines the specialised characteristics of mature glial cells (Xie et al., 2022; Farmer et al., 2016; Hill et al., 2019). This adaptation ensures glia that are finely tuned to …