Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"interactor"”.
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Studies on the autophagy gene WIPI4 and its interactor UBR5
Autophagy is a tightly regulated process that sequesters and delivers proteins and other cellular substances for degradation in the lysosome. Dysfunction of autophagy has been implicated in many diseases including neurodegenerative diseases, cancer, and infectious diseases. Beta-propeller …
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Characterization Of A Novel Interactor/substrate For The Pro-apoptotic Serine Protease Omi/htra2
… identified a novel protein (HOPS), as a specific interactor of Omi. The predicted amino acid sequence of this protein does not provide any information about its potential function in mammalian cells. However, experiments show that HOPS is cleaved in vitro by Omi. Furthermore, in response to …
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Characterization of a Novel Fis1 Interactor Required for Peripheral Distribution of the Mitochondrion of Toxoplasma Gondii
Toxoplasma’s singular mitochondrion is extremely dynamic and undergoes morphological changes throughout the parasite’s life cycle. While intracellular‚ the mitochondrion is maintained in a lasso shape that stretches around the parasite periphery and is in close proximity to the pellicle‚ suggesting …
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Validation of The Activation of Aurora B Kinase By Caenorhabditis Elegans to usled-Like Kinase and The Identification of Cyclin B3 As A Phospho-Specific Tlk-1 Interactor
… the C. elegans Tousled-like kinase (TLK-1) as an interactor and substrate activator of AIR-2. However, the role of TLK-1 kinase activity in TLK-1-promoted AIR-2 activation remained enigmatic. The research presented herein reveals that the Aurora B-activating role of TLK-1 is independent of TLK-1 …
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An investigation into the role of the ubiquitin-proteasome system in plant defence
… objective of this study was to identify the interactor of UBP12 by employing a yeast two hybrid screen. The final objective was to analyse the functional significance of the mutant forms of ubiquitin during ubiquitination of target protein. Added to the above-mentioned objectives, this study …
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AMPHIPODS ARE STRONG INTERACTORS IN THE FOOD WEB OF A BROWN-WATER SALMON RIVER
… We hypothesized that A. kygi are a strong interactor in the feedback loop which links dead spawner biomass to juvenile salmonid growth. We found that A. kygi had a complex life cycle with anadromous and resident forms. A. kygi dominated the macro-benthos, comprising more than 88.0% (SE=.01, …
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AMPHIPODS ARE STRONG INTERACTORS IN THE FOOD WEB OF A BROWN-WATER SALMON RIVER
… We hypothesized that A. kygi are a strong interactor in the feedback loop which links dead spawner biomass to juvenile salmonid growth. We found that A. kygi had a complex life cycle with anadromous and resident forms. A. kygi dominated the macro-benthos, comprising more than 88.0% (SE=.01, …
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Investigating the regulation of DNA non-homologous end-joining through Ku70/80 interacting factors
… paralog of XRCC4 and XLF (PAXX). As PAXX is a Ku interactor with a role in NHEJ, the effect of PAXX phosphorylation is investigated as a potential NHEJ regulatory system. Lastly, I investigate the role of the RecQ helicase WRN, whose precise roles in the DDR are unclear. As an interactor of both …
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The Use of C. Elegans to Identify Mutations That Confer Drug Resistance, Using Hemiasterlin as an Example
… identified Rps-1 most frequently as an interactor with HAR-2. Rps-1 is the homolog to the human S3A small ribosomal protein. Published reports show that increased expression of S3A is correlated with drug resistance and that S3A interacts with the anti-apoptotic factor Bcl-21. The …
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Characterizing the Role of Gds1p in the Saccharomyces cerevisiae Environmental Stress Response
… identified in a recent study as a physical interactor and acetylation target of NuA4. Gds1 protein level is dependant both on NuA4 and environmental stress and our analysis shows it to be involved in the nuclear exclusion of Msn2p in the absence of stress. Unstressed cells lacking GDS1 …
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FUNCTIONAL ANALYSIS OF ANAPLASTIC LYMPHOMA KINASE DURING EMBRYONIC NEUROGENESIS IN ZEBRAFISH
… tyrosine phosphatase zeta (RPTPz), a known Alk interactor, are briefly discussed.
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Investigating the transcription factor landscape of the squamous subtype of pancreatic ductal adenocarcinoma
… pioneer factor FOXA1 was identified as a top interactor of TP63, which were further shown to co-bind at transcriptional start sites and cis-regulatory elements across the genome in a panel of human squamous PDAC cell lines. Unexpectedly GATA6 which has historically been associated with being …
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Identification of Artemis and PARP-1 interacting factors: A yeast two hybrid screening approach
… The ATRX protein was identified as a putative interactor of Artemis, Caspase-7 and an "unkown" protein were identified as putative interactors of PARP-1 binding factors. In addition a rare case of false positives were identified and characterized. Furthermore, the strengths and limits of each …
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Multivariable Adaptive Control
… relaxes a result by Elliott /et al./ where the interactor is required to be known.The important question of stability of adaptive systems is also treated. The major result is a method for construction of Lyapunov functions for a class of single-input systems. Stability in the sense of Lyapunov …
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Identification and characterization of Sgo2 interactions - Insights into dynamic chromosomal localization, mechanism of cohesin protection and putative checkpoint function
… 2A (PP2A) was identified as a prominent interactor of shugoshins in this thesis. Shortly thereafter, it was reported that shugoshins protect cohesin by mediating PP2A-dependent dephosphorylation. Nevertheless, it is shown here for the first time that hSgo2 binds PP2A via its N-terminus. A …
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The regulation of TGFβ/BMP signalling by deubiquitylating enzymes
… USP15 was identified in a proteomic screen as an interactor of SMAD6, which is a negative regulator of the BMP pathway. USP15 also binds to and deubiquitylates the type I BMP receptor (ALK3), thereby enhancing BMP signalling. Consequently, USP15 impacts BMP-induced SMAD1 phosphorylation, mouse …
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An ancestral regulatory mechanism underlies Hoxd gene expression in both developing genitals and digits
… Cdx2 transcription factor as a putative interactor of the genitalspecific enhancers. These results suggest a common ancestral regulatory strategy for digits and genitals, yet with specific adaptations in each developmental context. This work should help understand the regulatory mechanism …
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Identification of the Pokeweed Antiviral Protein Interactome by Co-Immunoprecipitation-Mass Spectrometry
… spectrometry was used to identify PAP protein interactors in pokeweed. Results identified protein interactions with diverse cellular functions in both the extracellular matrix, where PAP is primarily localized, and the cytoplasm, where the ribosomal target resides. One interactor was identified …
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Elucidation and characterisation of checkpoint kinase interactions with the replisome
… biotin proximity labelling to elucidate novel interactors of the budding yeast checkpoint kinase Rad53 with the replisome. Using this technique, Pol1, a polymerase involved in DNA replication, was found to be a putative Rad53 interactor. Pol1 interacts with the FHA1 domain of Rad53 and …
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Function of a Unique Dually Localized EF-Hand Domain Containing Protein, TgEFP1, During the Lytic Cycle of the Human Parasite Toxoplasma Gondii
… protein- TgLectin (TGGT1_258950) as a direct interactor of TgEFP1-HA. Collectively, these findings support that through the function of TgEFP1, the PLV/ELC, plays a key role in calcium-dependent processes during the lytic cycle of the parasite.
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