Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"interaction domains"”.
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Retrobiosynthesis of D-glucaric acid in a metabolically engineered strain of Escherichia coli
… enzymes, promoters, and protein-protein interaction domains has led to productivity improvement. However, understanding behaviors of a synthetic pathway in an engineered chassis is still a daunting task, requiring global optimization. As the first step to understand pathway design rules …
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Maguk Scaffolds Organize A Key Synaptic Complex In Horizontal Cell Processes Contacting Photoreceptors
… large number and typically a variety of protein interaction domains that allow many different proteins to be assembled into functional complexes. As each scaffold protein has a different set of protein interaction domains and a unique set of interacting partners, the presence of synaptic …
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Investigations into membrane protrusions mediated by IRSp53 IMD
… of these structures, via various protein interaction domains. IRSp53 also contains an IMD (IRSp53/MIM homology domain), which is able to induce formation of filopodia-like structures when overexpressed in cells. Early reports suggested that the IMD exerts its effect by bundling actin …
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Hierarchy of Interactions in Protein Evolution
… by the sheer number of possible cooperative interactions amongst the parts that make up biological systems. For even small systems such as individual protein domains, it has been difficult to comprehensively obtain high quality empirical data of amino acid interactions to distinguish …
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Logic and Mechanism of an Evolutionarily Conserved Interaction in PDZ Domain
… Coupling Analysis (SCA), to estimate energetic interactions between residues in a protein from their statistical co-variation through evolution. The results of this algorithm revealed a small subset of the residues in a protein have significant energetic interactions and form a connected …
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Interaction studies of the cellular prion protein
… system followed by the identification of two interaction domains. The influence of mutations and polymorphisms within the prion gene was investigated in the yeast two-hybrid system. This method is also an useful tool for the investigation of the species barrier. To determine the role of …
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Decoding the structure WWP2 in the TGFβ signalling pathway
… system lies in the protein-protein interaction domains of the diverse group of E3 enzymes. WWP2 is one such E3 enzyme, and the relevant protein-protein interaction domain is the WW domain. WWP2 has four WW domains which are used to interact with proline-rich motifs found in the …
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Mikrotextur und magnetische Mikrostruktur in Hartmagneten aus (Nd,Pr)2Fe14B-Verbindungen
In der vorliegenden Arbeit werden die Zusammenhänge zwischen der magnetischen Mikrostruktur und der Ausrichtung der Kristallite, sowohl in Sintermagneten als auch in feinkristallinen, warmumgeformten Magneten auf Nd2Fe14B- und Pr2Fe14B-Basis, untersucht. Die EBSD-Technik (electron backscatter …
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Localization and Function of Bacterial Type III and IV Effector Proteins
… of signaling enzymes with modular protein interaction domains and subcellular localization motifs. These sophisticated regulatory mechanisms are crucial to the fidelity and efficacy of information relay in both space and time. Bacterial effector proteins are virulence factors that are …
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Decomposition of Proteins into Functionally and Evolutionarily Independent Cooperative Units
Understanding cooperative interactions within proteins is an important goal because cooperativity underlies protein functions such as catalysis, allostery, ligand binding and folding. Cooperative units within proteins can be revealed via an evolution based method called statistical coupling …
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Designing Explainable In-vehicle Agents for Conditionally Automated Driving: A Holistic Examination with Mixed Method Approaches
… from AI, social science, and human-computer interaction domains, design considerations were synthesized for improving the explainability of AVs and preventing associated risks. With information gathered from the first four studies, three types of adaptive IVIAs were developed based on …
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Evolutionary Constraints Specifying Protein Folding and Function
… the evolutionarily preserved interresidue interactions critical for the proteins' selective fitness. This set of information has provided a sufficiently detailed description of evolutionary design constraints to allow the design of novel WW domain sequences that fold and function like …
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Dissecting The Interaction Between P53 and Trim24
<p>Dissecting the Interaction of p53 and TRIM24</p> <p>Aundrietta DeVan Duncan</p> <p>Supervisory Professor, Michelle Barton, Ph.D.</p> <p>p53, the “guardian of the genome”, plays an important role in multiple biological processes including cell cycle, angiogenesis, DNA repair and apoptosis. …
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Structure-Function Analysis of Human Integrator Subunit-4
… scaffold molecule that facilitates the interaction between other members of the Integrator Complex</em>. </strong>To answer this question, the two important goals of this study were to: 1) identify the region of IntS4, which is important for snRNA 3′ end processing and 2) determine …
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Regulation of plant innate immunity: the role of protein import and the novel MOS4-associated complex
… this protein constitutively active without interaction with pathogens. snc1 displays a stunted phenotype that may be caused by both the accumulation of toxic compounds and energy squandered on unnecessary defence instead of normal growth. The distinctive morphological phenotype of snc1 is …
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Dissecting the regulatory roles and cellular functions of mammalian ZSCAN5B and primate-specific paralogs
… especially those including KRAB or SCAN protein-interaction domains, have evolved rapidly in mammals due to repeated rounds of gene duplication, deletion, and divergence. The functions of the encoded proteins, and the evolutionary role of their duplication and divergence, are not well understood. …
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Characterization of the 37-kDa/67-kDa laminin receptor as the cell surface receptor for the cellular prion protein
… heparan sulfate proteoglycan (HSPG)-dependent interaction sites mediating the binding of cellular PrP to the 37-kDa/67-kDa LRP/LR. The relationship between the 37-kDa LRP and the 67-kDa high-affinity LR is unknown so far. Both forms were observed in plasma membrane fractions of N2a cells. We …