Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 155 for “"interacting proteins"”.
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Isolation and Characterization of Estrogen Receptor- Interacting Proteins
… of ERs is modulated and mediated by diverse interacting cofactors. The initial aim of this thesis work was to identify ligand-, subtype- and/or cell typespecific ER-interacting proteins. I identified a number of nuclear extract-derived proteins that interact with immobilized ER ligand binding …
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Carbohydrate-Interacting Proteins from Two Nostoc (Cyanobacteria) Species
… surface layer homology (SLH) domain-containing proteins, likely candidates to be covalently attached to or non-covalently interacting with carbohydrate. Various protein sequence analyses indicated that the detected SLH domain containing proteins belong to a family of (putative) cyanobacterial …
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The Regulation of Microrna Biogenesis By Ribosome-Interacting Proteins
… 2 is the functional component. Many of the proteins involved in miRNA biogenesis share a common role in ribosomal RNA regulation. Here we characterize two ribosome-associated proteins that are important for miRNA biogenesis. In one study, we identified nucleolin as a positive regulator of …
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Identification of TbRP2-interacting proteins using proximity-dependent biotinylation (BioID)
… together with Arl3 is involved in trafficking proteins to the cilium. I have been studying RP2 function in the flagellated protist Trypanosoma brucei, a tractable model to study eukaryotic flagellum assembly but also a parasite of medical and veterinary importance in subSaharan Africa. Thus, …
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Identification and functional characterisation of novel APC/C interacting proteins
… of great interest to study other cellular proteins that interact with the APC/C as these proteins may also be important in cell cycle regulation and hence may enhance our understanding of the molecular basis of cancer. Therefore, the aim of my study was to identify novel APC/C interacting …
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Identification and functional characterisation of synaptic AMPA receptor-interacting proteins
… strength. iGluR family members bind synaptic proteins through their N-terminal domain (NTD), influencing synaptic and neuronal circuit function. The AMPAR NTD encompasses 50% of the receptor, extending midway into the synaptic cleft, exposing it to a protein-rich environment. The strength of …
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Investigating the Molecular Function of APP Interacting Proteins in Synaptic Neuromodulation
… subunits and genes encoding synaptic scaffolding proteins such as Shank2 and Nrxn1/2. These results identify CNTN4 as a novel regulator of AMPAR trafficking, acting through distinct but potentially complementary mechanisms to APP. Collectively, this thesis demonstrates that CNTN4 is a regulator of …
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Possible Interacting Proteins for Retinol Binding Protein and Cellular Retinol Binding Protein
… in type 2 diabetes. Looking for possible interacting partners for proteins such as RBP, can further elucidate the function of the protein and its possible role in type 2 diabetes. The Membrane Yeast Two Hybrid (MYTH) system allows for the study of possible interacting partners for membrane …
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The Role of Collagen Interacting Proteins in the Pathogenesis of Filifactor alocis
… particularly the role of collagen related proteins of F. alocis in the pathogenicity periodontal disease. The goal is to investigate the specific role of F. alocis proteases in the virulence and pathogenicity of periodontal disease. The overall objective of this study is to evaluate the …
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Proteomic analysis of TRIF interactome and functional characterisation of novel TRIF interacting proteins
… study, we sought to investigate the novel proteins and pathways that serve to modulate the functionality of TRIF. To this end, immunoprecipitation and LC-MS analyses of the overexpressed and endogenous TRIF immunocomplexes were performed. A disintegrin and metalloproteinase …
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Understanding HNF-1β through Identification of Interacting Proteins and Target Genes in the Kidney
… agenesis, hypoplasia, and cysts. Here, I studied interacting proteins and target genes to understand the function of HNF-1Beta in the kidney. Yeast two-hybrid screening was performed to identify binding partners of HNF-1Beta in the kidney. Zyxin and LPP were isolated as putative interacting …
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Using affinity purification -- mass spectrometry to identify aryl hydrocarbon receptor nuclear translocator interacting proteins
… belongs to the family of basic helix loop helix proteins. ARNT forms a heterodimer with aryl hydrocarbon receptor (AhR). This heterodimer binds to the dioxin responsive element (DRE) causing the regulation of the gene expression of some enzymes such as CYP1Al. Studies show that the ARNT-AhR …
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UNDERSTANDING THE RAL GTPASES: THE REGULATION BY PROTEIN LYSINE FATTY ACYLATION, SIRT2, AND INTERACTING PROTEINS
… acids in cell culture or SILAC) to identify the interacting proteins of RalA and RalB. This study revealed many interacting proteins that can bind to RalA, RalB, or both in a nucleotide dependent manner. These interacting proteins provide important insights that will guide future studies. For …
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Structural investigations of membrane-interacting proteins using nuclear magnetic resonance spectroscopy and other biophysical techniques
… well as its interactions with membrane and other proteins. Aberrant protein expression or disruption in protein-protein/protein-membrane interactions lead to disease formation. Membrane-interacting proteins play critical roles in a wide range of biological processes and their dysfunction …
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Functional Analysis of Insl5 and Insl6 Genes and Verification of Interactions between Pelota and its Putative Interacting Proteins.
Die Ziele dieser Arbeit waren einerseits die Untersuchung der Expression und Funktion von zwei Mitgliedern der Insulin-ähnlichen Proteinfamilie, Insl5 und Insl6, und andererseits die Bestätigung der Interaktion zwischen PELO und dessen putativen Interaktionspartnern CDK2AP1, EIF3G und SRPX.Um die …
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Quantitative Deubiquitinase (DUB) Interactomics to Dissect the Biology of Cancer Associated DUBs
… chains from ubiquitinated proteins. Deubiquitination is carried out by the class of enzymes called deubiquitinases (DUBs). These DUBs have vital roles in the regulation of protein ubiquitination and have a profound influence on the fate of proteins and their activity. …
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Study of the HIV-1 Gene Regulatory Proteins TAT and REV by the Two-hybrid System in Yeast
<p>Tat and Rev, small proteins encoded by the Human Immunodeficiency Virus type 1 (HIV-1), regulate its pattern of gene expression within infected cells. Tat increases transcription from the integrated pro virus by approximately a thousand-fold; Rev effects a shift in the pattern of splicing of the …
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Identification of interacting partners of mammalian target of rapamycin complex 1 (mTORC1) assembly in human lymphocytes
… of biological functions with the help of its interacting proteins. These interacting proteins act as scaffolds and recruit substrates and regulatory proteins required for mTOR kinase function. The present study was undertaken to identify novel interacting partners of mTORC1 that specifically …
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