Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 122 for “"interacting protein"”.
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P125, A COPII INTERACTING PROTEIN
Coat protein complex II (COPII) coated vesicles/carriers mediate the export of proteins from the ER via specialized domains known as the ER exit sites (ERES). p125A is a protein of 125 kDa that interacts with Sec23A, a component of the COPII coat. It was found to participate in the organization of …
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Characterization of zebrafish zipper-interacting protein kinase
<p>Zipper-Interacting Protein Kinase (ZIPK) is a known modulator of actin-myosin contractility in vertebrate species. Interestingly, rodent and mouse ZIPK has undergone a divergence in regulation in comparison to other vertebrate orthologs including human. Whereas the human ortholog of ZIPK …
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Molecular Mechanism of Zipper Interacting Protein Kinase
… by several kinases which include zipper interacting protein kinase (ZIPK). Our laboratory has shown that ZIPK is able to phosphorylate and inhibit SMPP-1M which results in increased smooth muscle contraction. Additional studies demonstrated that ZIPK is also regulated by phosphorylation. …
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Characterization of the zebrafish zipper interacting protein kinase homolog
… The characterization of 6 zebrafish Zipper Interacting Protein Kinase homolog has helped to better understand how changes in cell cytoskeletal elements can lead to changes in cell shape and movement. Zebrafish are ideal model organisms for studying ZIPK because it has been previously shown …
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Interactions between IP3 receptor and Kras-induced actin-interacting protein
… the association with Kras-induced actin-interacting protein (KRAP). The immobility of the licensed IP3R fraction is attributed to its interaction with KRAP, which anchors IP3R to actin filaments near plasma membrane (PM)-ER junctions. Given the reported upregulation of KRAP in cells with …
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Toll-Interacting Protein Regulation of Low-grade Non-resolving Inflammation
… circuitries modulated by adaptor molecules. Toll-interacting protein (Tollip) is one of the critical adaptor molecules in Toll-like receptor 4 (TLR4) signaling and potentially playing key roles in modulating the dynamic adaptation of innate leukocytes to varying dosages of external stimulants. …
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Regulation of Host Immune Responses by Toll-Interacting Protein During Citrobacter rodentium Infection
… and are critical for pathogen clearance. Toll-interacting protein (Tollip) is an intracellular mediator of several immune mechanisms. Tollip negatively regulates TLR activation, and acts as a mediator of autophagy and endosomal transport. These mechanisms are involved in processes such …
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… CB1R is one of the most abundantly expressed G protein coupled receptors (GPCR) in the CNS and has been targeted therapeutically for multiple diseases; however side effect profiles for CB1R have posed difficulty in the development of clinically successful CB1R drugs. The identification of GPCR …
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Angiomotin Is A Novel Cadherin-11 Interacting Protein That Mediates Migration In Prostate Cancer Cells
… and epithelial cell polarity, as a Cad11 interacting protein. Deletion analysis showed that the last C-terminal 10 amino acids in Cad11 mediated Amot binding. Further, Cad11 preferentially interacts with the Amot-p80 isoform than the Amot-p130. Analysis of Amot mutants showed that Amot-p80 …
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Investigating the neuroprotective role of carboxyl-terminus of Hsc70-interacting protein (CHIP) in healthy aging
… to the normal, healthy aging process. Given that protein homeostasis is a major contributor to both normal and malignant aging, the ubiquitin-proteasome system is a promising candidate for teasing apart the pathways driving both healthy and pathological processes. E3 ubiquitin ligases catalyse the …
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MED9, a Mediator Complex Component, and its Interacting Protein MORC1 Balance Growth and Defense in Arabidopsis
… supercoiling. I identified 14 MORC1-interacting proteins (MIPs) via yeast 2-hybrid screening, eight of which have putative nuclear-associated functions. While a few loss-of-function mutants for these MIPs displayed altered bacterial resistance in Arabidopsis, MIP13 was highly unusual. …
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Optimization of Receptor-Interacting Protein Kinase 2 (RIPK2) Inhibitors and Development of Mixed Lineage Kinase Domain-Like (MLKL) Activators
Protein kinases and pseudokinases play pivotal roles in complex cellular signaling and regulatory pathways. Protein kinases’ catalytic activity is critical for controlling a myriad of cellular events and functions. Despite a lack of catalytic activity, pseudokinases have merged as nuanced …
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FUNCTIONAL CHARACTERIZATION OF DENND5A/RAB6IP1 IN EARLY EMBRYONIC DEVELOPMENT
… cells, Dennd5a or Denn domain containing protein 5a is also named Rab6 interacting protein 1 (Rab6ip1), KIAA1091 (HUGE database). Rab6 is a small GTP-binding protein that involves in intra-Golgi transport. In a yeast two hybrid screen by Bruno Goud group in 1995, they used Rab6 as bait and …
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Study of correlation analysis for protein-protein interactions
Protein-protein interactions take place when two or more proteins bind together, usually to carry out some biological functions. Many biological processes are formed by interaction networks that are consisted of more than one protein-protein interaction. To understand the proteins’ function …
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Exploring protein interactions and intracellular localization in regulating flavonoid metabolism
The organization of biological processes via protein-protein interactions and the subcellular localization of enzymes is believed to be fundamental to many aspects of metabolism. Although this organization has been demonstrated in several systems, the mechanisms by which it is established and …
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Identification of Phosphorylase Kinase Alpha Subunit Binding Partners in Skeletal Muscle
… to associate extrinsically with skeletal muscle proteins due to its peripheral location in the holoenzyme. To identify potential muscle protein interactors, the C-terminus of α , amino acid residues 1060-1237, was screened against a rabbit skeletal muscle cDNA library via a yeast two-hybrid …
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Regulation of rod photoreceptor phosphodiesterase (PDE6) by the glutamic acid -rich protein 2 (GARP2)
… the high efficiency of activation by the G-protein, transducin, and the precise control of its inactivation. In addition to binding to transducin during visual excitation, PDE6 is hypothesized to be regulated by other interacting proteins.</p><p>The first aim of this research was to isolate …
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Computational Modeling of Rna-Small Molecule and Rna-Protein Interactions
… still remain when one aims to screen RNA-interacting small molecule or RNA-interacting protein. These challenges imply an immediate need for cost-efficient while predictive computational tools capable of generating insightful hypotheses to discover novel RNA-interacting small molecule or …
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THE ROLE OF THE PROLINE-RICH TYROSINE KINASE 2 PROTEIN IN THE REGULATION OF METABOTROPIC GLUTAMATE RECEPTOR SIGNALLING
… develop treatment for mGluRs, we must identify proteins involved in their signalling. We have identified proline-rich tyrosine kinase 2 (Pyk2) as an mGluRl/5 interacting protein, and our objective was to investigate its contribution to the downstream activation of extracellular signal-regulated …
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Roles for C-ABL and P53 in bone homeostasis and DNA damage response
… defects of mice lacking c-Abl, a p53 interacting protein. We provide evidence that c-Abl, a non-receptor tyrosine kinase, acts at a novel step that affects most cellular events in DNA damage response. c-Abl-/- MEFs showed defects in nuclear foci assembly of adaptor proteins such as …
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