Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"inter domain interactions"”.
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Investigating 3D genome organisation in Caenorhabditis elegans with Accessible Region Conformation Capture (ARC-C)
… Capture (ARC-C), in C. elegans, which interrogates genome organisation at multiple scales genome-wide - from domains and compartments to high resolution interactions between regulatory elements. I applied ARC-C in wild-type Bristol N2, met-2 set-25 mutants that have no H3K9 methylation …
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Phase Phenomena of Proteins in Living Matter
… this thesis answers an important question at the interface of physics and biology: how does the crowded cellular environment influence the dynamics of individual proteins and their folding phases? This thesis is presented in two parts. First, we review protein folding and investigate the effects …
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Probing Interactions Between Canonical NOX Domains
… comprising a heme-containing transmembrane (TM) domain and a cytoplasmic dehydrogenase (DH) domain that binds the substrate NADPH and the cofactor. Previously, NOXes were only characterized in eukaryotes, but have recently been identified in prokaryotes, namely bacteria. Due to their constitutive …
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Transcriptional regulation and enzymatic functions of the Escherichia coli biotin protein ligase
… adenylate (biotinoyl-5'-AMP), the obligatory intermediate of the ligation reaction. In this thesis I carried out an in-depth analysis of the BirA protein from E. coli using a combination of mutational and biochemical analysis. These studies provide the first strong evidence that the …