Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"integrin-α7"”.
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Integrins in muscle disease and repair
Integrin α7β1 plays an important role in maintaining adult skeletal muscle integrity and like dystrophin, provides anchorage and bidirectional signaling as a laminin receptor. The expression of α7β1 integrin was upregulated upon dystrophin deficiency arguing for the molecular compensation and thus …
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Identification of a first in-class integrin enhancing small molecule for the treatment of Duchenne Muscular Dystrophy
… treatment options exist for patients. The α7β1 integrin is an additional laminin-binding heterodimeric protein at the sarcolemma that is elevated in the skeletal muscle of DMD patients and the mdx mouse model. Previous pharmacological and transgenic mouse studies have demonstrated that the …
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The role of recombinant human laminin-111 in adhesion-signaling and glycosylation in laminin-⍺2 deficient muscle
… Golgi complex organization influenced by integrin-α7 binding. Altogether, these findings highlight novel mechanistic insights into laminin's role in regulating many integral biological pathways and the therapeutic potential of rhLAM-111 for mitigating disease progression in LAMA2-CMD.