Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"integrative modelling"”.
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INTEGRATIVE MODELLING FOR THE CHARACTERISATION OF THE STRUCTURE AND DYNAMICS OF BIOMOLECULES
… the inherent limitations of each approach. Integrative modelling provides a more comprehensive understanding of the structure, dynamics, and function of complex biomolecular systems. Experimental data can guide computational methods, improving accuracy, reducing limits and approximations, …
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RADIOMICS FOR OUTCOME PREDICTION IN EARLY-STAGE NON-SMALL CELL LUNG CANCER PATIENTS TREATED WITH STEREOTACTIC BODY RADIOTHERAPY (SBRT): METHODOLOGICAL CHALLENGES AND CLINICAL APPLICATIONS
… This study- named MONDRIAN (Multi-omics integrative modelling for stereotactic body radiotherapy in early-stage non-small cell lung cancer)-will provide the unprecedented opportunity to characterize the disease, and to elucidate the interaction between determinants of radiosensitivity and …
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Multivariate linear mixed models for statistical genetics
… thesis demonstrates the value of flexible and integrative modelling in genetics and contributes new statistical methods for genetic analysis. These approaches generalise previous models, yet retain the computational efficiency that is needed to tackle large genetic datasets.
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How is Ataxia-Telangiectasia Mutated Protein Kinase Activated?
Ataxia-Telangiectasia Mutated (ATM) is a key protein kinase in the cell’s response to double-stranded breaks in DNA. This damage is detected by the Mre11-Rad50-Nbs1 (MRN) complex, which recruits ATM to the DNA. Upon activation, ATM phosphorylates a vast range of substrates, which triggers a …
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Small Molecule Binding to Disordered Proteins
The human proteome includes many proteins that are entirely disordered or contain long disordered regions. Although these proteins are linked with many diseases, there are currently no clinically-approved drugs that have been shown to target these proteins in their monomeric forms. In fact, …