Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"integrative genomic"”.
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Integrative genomic analyses of bacterially-associated colorectal cancer
… clinicopathological features of CRC and genomic subtypes of CRC been investigated. The main aim of this thesis was therefore to gain insight into the potential contribution of CRC-associated bacteria in the aetiopathogenesis of CRC by leveraging both host genomic and clinicopathological …
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Integrative genomic analysis of Neurogenin2 reprogramming of human iPSCs
… hallmarks, I designed a time course-based genomic analysis that investigated the transcriptional and chromatin accessibility states of cells undergoing NGN2 reprogramming. Bulk RNA and ATAC-sequencing were performed at Day 0, 6h, 12h, Day 1, 36h, Day 2, Day 3, Day 4, Day 14 and Day 21 …
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Integrative genomic approaches to dissecting host-tumor and host-pathogen immune processes
… we conducted a systematic exploration of how the genomic landscape of cancer shapes and is shaped by anti-tumor immunity. Using large-scale genomic data sets of solid tissue tumor biopsies, we quantified the cytolytic activity of the local immune infiltrate and identified associated properties …
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Integrative Genomic Approaches for Plant Trait Discovery, Fungal Pathogen Identification and Taxonomy
Genomics underpins crop improvement and plant health surveillance, yet its application remains constrained by incomplete detection of complex genetic variation, difficulty recovering pathogen genomes directly from diseased tissues, and inconsistent reference resources for fungal and oomycete …
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VDAC1P8 as a Novel Regulatory Element in Leukemogenesis: Integrative Genomic, Epigenetic, and Functional Insights [VDAC1P8 come nuovo elemento regolatorio nella leucemogenesi: approfondimenti genomici, epigenetici e funzionali integrati]
… patologiche. Incrociando i dati di più database genomici e trascrittomici, è stata osservata una correlazione tra le variazioni dei livelli di espressione del gene VDAC1 e di alcuni pseudogeni, in particolare lo pseudogene VDAC1P8, che ha indirizzato la nostra attenzione su alcuni tumori, la …
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Identification and Characterization of In-planta Expressed Secreted Effector Proteins from Magnaporthe oryzae
… substrate. This study demonstrates that our integrative genomic approach is effective for the identification of in-planta expressed cell death-inducing effector from M. oryzae, which may play important role facilitating colonization and fungal growth during infection. Characterization of …
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Oncostatin M Receptor Overexpression Promotes Tumour Progression in Squamous Cell Carcinoma, via Hypoxia Signalling and Multiple Effects on the Tumour Microenvironment
… role in cervical carcinoma initiation, but other genomic changes are needed for pre-malignant abnormalities to fully develop to cancer. This often happens through genomic instability caused by the virus oncoproteins. Several integrative genomic analysis studies have found that one of the most …
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Mixture Model Approaches to Integrative Analysis of Multi-Omics Data and Spatially Correlated Genomic Data
<p>Integrative genomic data analysis is a powerful tool to study the complex biological processes behind a disease. Statistical methods can model the interrelationships of the involved gene activities through jointly analyzing multiple types of genomic data from different platforms (vertical …
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GENOMIC AND EPIGENETIC APPROACHES IN THE CLINICAL AND PROGNOSTIC STRATIFICATION OF CHRONIC LYMPHOCYTIC LEUKEMIA
… risk subgroups of CLL patients using both genomic (integrated FISH and microarray technology) and an epigenetic approach in highly purified B-cell populations obtained from early-stage CLLs (Binet stage A). The availability of information concerning the follow-up of the analyzed patients …