Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"integrative analysis"”.
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Bayesian Integrative Analysis of Omics Data
… proteomic data, imaging data and clinical data. Integrative analysis of such data sets have potentiality in revealing important biological and clinical insights into complex diseases like cancer. This dissertation focuses on Bayesian methodology establishment in integrative analysis of …
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Integrative analysis of the metastatic neuroblastoma transcriptome
… in differentially-spliced genes. ChIP-seq analysis showed direct binding of MYCN to promoter regions of splicing factors PTBP1 and HNRNPA1, demonstrating that MYCN regulates splicing by directly regulating expression of key splicing factors. Furthermore, high expression of PTBP1 and HNRNPA1 …
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Integrative analysis of heterogeneous plant cell wall related data
… rather than the component centric view, integrative analysis of the different cell wall components across system-levels help to gain a more in-depth understanding of the structure and biosynthesis of the cell envelope and its interactions with the environment. To this end, in this work …
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Integrative analysis of transcriptional regulatory programs in mammalian systems
Gene regulatory network (GRN) is the most central known information processing program of life. To understand its importance and complexity, it is sufficient to note that all the cells in our body contain the same genetic code yet carry out functions ranging from energy storage to immune response. …
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Integrative Analysis of the Human Gut Phageome Using a Metagenomics Approach
… this thesis, I carry out a comprehensive genomic analysis of gut phages by harnessing the biggest collection of phage genomes, gut bacteria isolates, and human gut metagenomes. I begin by introducing the Gut Phage Database (GPD) which is the largest genomic resource to date of human gut phage …
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Integrative analysis of transcriptomic data to elucidate regulators of pre-mRNA processing
… author contribution that advances splicing analysis by enabling more accurate identification and quantification of both simple and complex AS events. A key innovation introduced is the MAJIQ v2 Modulizer, which facilitates regulatory analysis by decomposing complex splicing patterns into …
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An Integrative Analysis of Fruit Shape in Capsella rubella and Arabidopsis thaliana
… an elaborate heart-shaped fruit. I used clonal analysis to generate a description of regional growth dynamics within the tissue. Using this data, I generated computational models to explore the coordination of growth and polarity in the Capsella fruit. Based on observations of morphology, growth …
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Statistical methods for the integrative analysis of single-cell multi-omics data
… to be accompanied by the development of suitable integrative strategies to fully exploit the data generated. In this thesis I worked in collaboration with different research groups to introduce innovative experimental and computational strategies for the integrative study of multi-omics at …
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Integrative analysis of transcriptional activity and genome architecture changes upon viral infections
To study the interplay between spatial nuclear architecture and transcriptional activity during viral infections, I employed a genome-wide chromosome conformation capture approach (Hi-C) on infected murine and human cells and further enriched those libraries for genomic loci of interest and the …
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Integrative analysis of high-throughput biological data: shrinkage correlation coefficient and comparative expression analysis
… is not only applicable to DNA microarray analysis but is also applicable to proteomics data or any other high-throughput analysis methodology. The suppression of APY1 and APY2 in mutants expressing an inducible RNAi system resulted in plants with a dwarf phenotype and disrupted auxin …
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Integrative analysis of heterogeneous genomic datasets to discover genetic etiology of autism spectrum disorders
… for the first time. Finally, we provide a novel integrative approach for combining CNV, phenotype similarity, and topology-related information with existing knowledge from literature. Our integrative approach outperforms the individual schemes in identifying and ranking ASD related genes. Our …
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Mixture Model Approaches to Integrative Analysis of Multi-Omics Data and Spatially Correlated Genomic Data
<p>Integrative genomic data analysis is a powerful tool to study the complex biological processes behind a disease. Statistical methods can model the interrelationships of the involved gene activities through jointly analyzing multiple types of genomic data from different platforms (vertical …
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Predicting molecular markers of development and regeneration through integrative analysis of high-throughput genomics data
… was analyzed using a novel clustering method. Analysis of transcripts enriched in markers demarcating undifferentiated and differentiated cells revealed that aggregate functions could be defined for markers of differentiated cells, but not for those in undifferentiated cells. In addition, the …
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Integrative Analysis of Policy Changes for a Coastal Watershed: Implications for Agriculture and Ecosystem Health
This dissertation explores the integration of hydrological modeling, the effects of sea level rise, and socio-economic factors influencing watershed management in North Carolina, primarily utilizing the Soil and Water Assessment Tool Plus (SWAT+) with four independent publication chapters. The …
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Integrative Analysis of Omics Data In Adult Glioma and Other Tcga Cancers to Guide Precision Medicine
… through both transcriptional and protein level analysis using a panel of sphere-forming glioma cultures and their parent GBM samples.FurthermoreI have demonstrated my hypothesis through longitudinal analysis of paired primary and recurrent GBM samples that the phenotypic alterations of GBM …
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An integrative analysis of the multi- and transgenerational effects of endocrine-disrupting chemicals on behavior and neurobiology
Endocrine-disrupting chemicals (EDCs) are ubiquitous environmental pollutants that are known to interfere with hormone action. Exposure to EDCs during hormone-sensitive periods of prenatal development can result in disease and dysfunction later in life. Furthermore, EDC effects have been reported …
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Integrative Analysis of the Myc and E2F pathway Reveal the Roles for microRNAs in Cell Fate Control
… to Myc and E2F pathway activities. Through integrative analysis of mRNA and miRNA expression profile, we observe a distinct regulatory pattern in which, in the case of Myc pathway, Myc-induced miRNAs were contributing to the repression of negative regulators of cell cycle, including PTEN, …
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Detection of Novel Genomic Markers for Predicting Prognosis in Hepatocellular Carcinoma Patients by Integrative Analysis of Copy Number Aberrations and Gene Expression Profiles: Results from a Long-Term Follow-Up
… hepatocellular carcinoma (HCC) prognosis by integrative analysis of DNA copy number aberrations (CNAs) and gene expression profiles. Array comparative genomic hybridization and expression array were performed on 45 and 31 HCC samples, respectively. To identify functionally important genes, …
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Harnessing Cancer Omics to Inform Precision Oncology
… profiling data, there is imperative need for integrative analysis of molecular and clinical information in an efficient way. Here, we conducted omics analysis on three different cancer studies and developed an LLM-based bioinformatics chatbot, DrBioRight, that can perform cancer omics data …
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Revealing disease-associated pathways and components by systematic integration of large-scale biological data
… network-based, machine-learning algorithm for integrative analysis of untargeted metabolomic data. Metabolites are small molecules whose levels directly show cellular phenotypes. Despite their potential, the integrative analysis of metabolomic data has been limited because of challenges in …
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