Global ETD Search
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Showing 1 to 4 of 4 for “"integration site analysis"”.
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Insights into the clonal inventory of gene corrected human SCID-XI hematopoiesis
The semi-random nature of retroviral integration introduces a stable molecular marker into the cellular genome in the form of a genomic-proviral fusion sequence which can be passed on unmodified to all the progenies of a transduced cell. Retroviral integration site analysis provides a powerful …
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Multi-Pronged Approach to Understanding the Toxicity Associated with CAR T-Cell Therapy
… transcriptomic, and functional strategies. Virus integration is essential for CAR expression, yet the biological consequences of integration are not yet fully understood. Integration site profiling therefore provides a means to assess whether certain patterns are associated with functional …
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Molekulare Analysen zur Pluripotenz und Langzeitaktivität retroviral transduzierter hämatopoetischer Stammzellen
… Rhesusaffen untersucht. Die genomische Integrationsstelle retroviraler Vektoren ist ein stabiler individueller DNA-Marker für jede transduzierte Zelle. Aus Leukozyten-DNA des Rhesusaffen wurden mehr als 80 Integrations-stellen durch ligationsmediierte PCRs identifiziert. Um aus dieser …
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The Impact of Radiation on Glioblastoma Evolution
… cell lines that underwent γH2AX foci analysis and limiting dilution assay analysis. Cell lines from the same tumour seem to display similar levels of intrinsic radiosensitivity despite genomic differences, suggesting that radiotherapy regimens may be effective for the whole of the …