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Showing 1 to 2 of 2 for “"integration mutagenesis"”.
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Proteins mediating somatic hypermutation and class switch recombination at the immunoglobulin locus
… factors required for SHM and CSR. By retroviral integration mutagenesis we found the chaperone Tid-1 as a potential missing factor. As a second candidate, we studied the chromatin-remodeling factor Supt6h, which is thought to help transcription by displacing histones for the RNA polymerase II to …
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Gewinnung von Gärungsmutanten der Hefe Pichia stipitis durch zufällige Integrationsmutagenese
… be cleared up. In this dissertation an efficient integration mutagenesis was developed for P. stipitis to generate putative fermentation mutants for further examinations. This system leads to accidental, marked and ectopic integrations by means of integrative transformation of a linear vector. The …