Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"insulin-like growth factor binding protein"”.
-
The Role of Insulin-Like Growth Factor Binding Protein 3 in Mitochondrial Homeostasis
Pages 15-102 are misnumbered as pages 14-101, pages 103-155 are misnumbered as pages 100-152, and pages 156-192 are misnumbered as pages 151-187.
-
Progesterone Regulation of Insulin like-Growth Factor : Binding Protein-5 Gene Transcription in Human Osteoblasts
<p>Insulin-like growth factor binding protein-5 (IGFBP-5) is produced by osteoblasts and potentiates IGF mitogenic actions in osteoblast cultures. Progesterone (PG) increases osteoblast proliferation and increases osteoblast IGFBP-5 expression. Mechanisms underlying PG induction of IGFI3P-5 …
-
Functional analysis of insulin-like growth factor binding protein -4 and -6 in transgenic mice
Insulin-like growth factors (IGF-I and IGF-II) are expressed in many cell types and tissues and act in endocrine, autocrine or paracrine manner to regulate cellular proliferation, survival and differentiation. IGF actions are initiated upon binding to the type I IGF receptor (IGF-IR) and are …
-
Insulin-Like Growth Factor Binding Protein-6: Posttranslational modifications and sorting in polarized MDCK cells
Die Insulin-ähnlichen Wachstumsfaktoren ("insulin-like growth factors", IGFs) stimulieren Wachstum und Differenzierung verschiedener Zelltypen. Die Verfügbarkeit der IGFs und ihre Interaktion mit spezifischen IGF- Zelloberflächenrezeptoren werden von sechs strukturell ähnlichen …
-
Ruolo del lattato e della proteina Insulin-Like Growth Factor Binding Protein 6 nel Glioblastoma Multiforme
… fattori di crescita, è stato riportato che la proteina 6 legante il fattore di crescita insulino-simile (IGFBP6), un inibitore delle azioni dell'IGF-II, svolge un ruolo importante nella sopravvivenza e nella migrazione delle cellule tumorali, ma i suoi effetti sull'interazione tra tumore e …
-
Insulin-Like Growth Factor-Binding Protein 2 Supports Hematopoietic Stem Cell Expansion: From In Vitro to In Vivo
… needed. We previously showed that angiopoietin-like proteins (Angptls), a group of growth factors isolated from a fetal liver HSC supportive cell population, improved ex vivo expansion of HSCs. Here we demonstrate that insulin-like growth factor binding protein 2 (IGFBP2), secreted by a …
-
Insulin-like growth factor binding protein-3 (IGFBP-3) plays an essential role in cellular senescence: molecular and clinical implications.
Normal somatic cells have a limited proliferative capacity in vivo and in vitro, termed senescence and later, thought to contribute to molecular and cellular organismal aging. There are several studies that demonstrate the importance of the GH/IGF axis in longevity, aging and cellular senescence. …
-
An investigation of insulin-like growth factor binding protein-5 (IGFBP-5) as a biomarker for the detection of early liver disease
… One such biomarker that was proposed was insulin-like growth factor-binding protein-5 (IGFBP-5). IGFBP-5 is known to be involved in the wound healing response in epithelial tissues, and its expression is switched on in fibrosis of the lung. IGFBP-5 induces epithelial cell senescence, an …
-
Investigations of Insulin-Like Growth Factor I Cell Surface Binding: Regulation by Insulin-Like Growth Factor Binding Protein-3 and Heparan Sulfate Proteoglycan
… to gain insight on how cellular activation by a insulin-like growth factor (IGF-I), in the presence of insulin-like growth factor binding protein-3 (IGFBP-3), is influenced by heparan sulfate proteoglycans (HSPG). Initial research will be presented, assumptions and hypotheses that were included …
-
Characterization of Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) interaction with the Bovine Aortic Endothelial (BAE) cell surface: Examination of the Role of Heparan Sulfate Proteoglycans (HSPG)
Insulin-like growth factor binding proteins (IGFBPs) are known to be important modulators of the insulin-like growth factor (IGF-I). However, their precise role is as yet unclear. Further, recent studies have indicated that IGFBP-3 has a receptor mediated growth inhibitory response of its own. In …
-
Molecular regulation of neuronal apoptosis in PC12 cells.
… of VM26 exposure, clusterin (TRPM-2) and IGFBP2 (Insulin-like growth factor binding protein 2) were both upregulated by 3 and 4 fold respectively. Cathepsin B (RSG-2) and RSG-3 (embigin) exhibited marginal changes in expression, only about 1.2 fold, over the 24 hour time course. Finally, IGFBP5 …
-
Metabolic Responses During Recovery From Prolonged Exercise: Role of Nutrition and Hormones
… research was to investigate the regulation of insulin-like growth factor binding protein-1 production following exercise. Prolonged exercise increased plasma and hepatic levels of IGFBP-1. Neither plasma insulin and glucose levels, nor meal composition altered IGFBP-1 production following …
-
Comparison on metabolic markers and hormone level according to serum 25-hydroxyvitamin D level
… lipid profile, high sensitive C-reactive protein, homocysteine and white blood cell counts were measured. Insulin like growth factor-I, insulin like growth factor binding protein 3, and sex hormone binding globulin level were measured. We divide the subjects into noraml vitamin D group and …
-
Igfbp2 Potentiates Egfr-Stat3 Signaling In Glioma
… nature and ineffective standard therapy. Insulin-like growth factor binding protein 2 (IGFBP2) is a pleiotropic oncogenic protein that has both extracellular and intracellular functions. Despite a clear causal role in cancer development, the contributions of intracellular IGFBP2 to tumor …
-
IGFBP-3 blocks hyaluronan-CD44 signaling, leading to increased acetylcholinesterase levels in A549 cell media and apoptosis in a p53-dependent manner
<p>Insulin-like growth factor binding protein-3 (IGFBP-3) belongs to a family of six IGF binding proteins. We previously found that IGFBP-3 exerts its cytotoxic effects on A549 (p53 wild-type) cell survival through a mechanism that depends on hyaluronan-CD44 interactions. To shed light on the …
-
Local regulation of increased milk yield due to early lactation increased milking frequency
… IMF significantly increased milk, fat, and protein yields in the right udder halves by 2.27 kg/d, 73.5 g/d, and 68 g/d respectively through the first 210 DIM (P < 0.001). At d 21, the right udder halves had a significant increase in activated signal transducer and activator of transcription …
-
In Vitro and In Vivo Studies on Bone Formation
… and 2) evaluation of the in vivo effects of Insulin-like Growth Factor Binding Protein-5 (IGFBP-5) as a potential means to treat osteoporosis.</p> <p>The first study compared two strains of inbred mice, one with high bone density and one with low bone density, to determine when and to what …
-
The Influence of Insulin-like Growth Factor Pathway Gene Polymorphisms on the Strength Training Response of Muscle Phenotypes in Older Adults
… polymorphism in the promoter region of the insulin-like growth factor 1 (IGF1) gene influenced the muscle strength response to ST in Caucasians. Other studies have shown that the insulin-like growth factor binding protein-3 (IGFBP-3) is a modulator of IGF-1 in circulation and is present in …
Page 1 of 2