Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"insulin-like growth factor 1 receptor (IGF1R)"”.
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Modulation of Pi3K-Akt Pathway In Colorectal Cancer
… only modest in patients. Expression of several receptor tyrosine kinases (RTKs) increased after AKT inhibition; insulin like growth factor 1 receptor (IGF1R) was significantly upregulated in patients, PDX and cell lines (P</p> <p>The PI3K pathway also modulates tumor immune microenvironment and …
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Targeted Inhibition of Pi3K, Mtor, and Igf1R For The Treatment of Undifferentiated Pleomorphic Sarcoma
… therapy was insufficient to eliminate tumor growth, and immunohistochemical analysis revealed that PI3K/mTOR inhibition activates insulin-like growth factor 1 receptor (IGF1R), potentially as a mechanism of adaptive resistance. Combined inhibition of PI3K, mTOR, and IGF1R via small molecule …
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Heterogeneity and Impaired IGF1R Signalling in Aged B cell Development
… Upon activation, their immunoglobulin B cell receptor (BCR) is secreted as antibody to neutralise pathogens or mediate the immune response. A diverse repertoire of immunoglobulin molecules is therefore essential for immune surveillance. As we age however, antibody diversity declines, as does …
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Investigation of IGF1R/IRS1 Signalling Mechanisms in B Cell Development
… recombination. This assembles a complete B cell receptor (BCR) and is the primary step in producing a diverse BCR repertoire; an essential requirement for a robust adaptive immune response. The roles of interleukin-7 receptor, pre-BCR and chemokine receptor type 4 signalling are well established …
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THERAPEUTIC POTENTIAL OF TARGETING THE FLNA-REGULATED WEE1 KINASE PATHWAY IN ADRENOCORTICAL CARCINOMAS.
… due to its role in negatively regulating the insulin-like growth factor 1 receptor (IGF1R) signalling. Upregulation of Wee1 nuclear kinase, a key regulator of G2/M cell cycle checkpoint, was shown in mouse neural progenitor cells lacking FLNA, and it has been reported in several cancers. The …
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Gene variations of FABP4, SCD, GH, and IGF1R and their associations with meat and carcass traits in sheep : A thesis submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy at Lincoln University
… in phenotypic traits, including meat quality, growth rate, and carcass composition, provide substantial benefits to the animal production industry. Given that these traits are governed by complex gene interactions, research aimed at identifying variations in candidate genes that drive desirable …