Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 27 for “"insulin therapy"”.
-
Injectable Systems for Long-Lasting Insulin Therapy
… of 2040 causing significant economic burdens. Insulin therapy has been the mainstay of diabetes treatment since its discovery in 1922. However, insulin is an unstable peptide with a half-life of only 4-6 min which poses significant challenge in prolonging duration of action of insulin. …
-
The Relationship Between Insulin Therapy and Cancer Incidences in Patients with Diabetes : Follow up study in Korea
연구목적 : 당뇨병환자에 있어 당뇨병 자체와 암 발생, 인슐린, 지속성 인슐린 유사체인 인슐린 글라진, 메트포르민 투여가 암 발생에 어떠한 영향을 주는지에 대한 대규모 역학연구가 해외에서 많이 이루어지고 있으나 아직 결론이 없는 상태이다. 국내에서는 이에 대한 역학연구가 부족한 상황으로 당뇨병과 암, 인슐린 사용과 암 발생의 연관성에 관하여 국내 추적 관찰연구를 시행코자 하였다. 대상 및 방법 : 제 2형 당뇨병 임상연구센터 코호트에 2005년 9월부터 2010년 10월까지 등록된 30세 이상 3,907 명의 참여환자를 2011년 …
-
The effect of insulin treatment and exercise modality on skeletal muscle fiber size in streptozotocin-induced type 1 diabetic rats
… muscle fibers. However, the role of intensity of insulin treatment and exercise modality in attenuating this loss in fiber cross-sectional area (CSA) specifically has yet to be determined. The purpose of this investigation was to determine the effects of 12 weeks of differing intensity of insulin …
-
What are the experiences of people with type 2 diabetes commencing insulin who are enrolled in a regional diabetes encounter programme?
… a person with type 2 diabetes to be commenced on insulin therapy. In New Zealand a regional programme has been introduced, designed to provide six funded consultations for people with type 2 diabetes when commencing insulin therapy. However, little is known about the experiences of people who have …
-
A survey of ICU professional nurses' knowledge of blood glucose physiology and blood glucose control in critically ill adult patients in a public tertiary hospital in the Western Cape Province
Blood glucose control with intravenous insulin therapy is one of the most frequently used treatment modalities to manage hyperglycaemia in critically ill patients. Almost all critically ill patients admitted in the Intensive Care Unit (ICU) will require blood glucose control to manage stress …
-
Barriers to initiating insulin therapy for patients with poorly controlled type 2 diabetes mellitus on maximum dose of oral agents in public sector primary health care centres in Cape Town, South Africa
… and have unsatisfactory glycaemic control. Insulin therapy is indicated in patients with type 2 diabetes, with inadequate metabolic control on maximum oral therapy. Insulin can be initiated in these CHCs.
-
Glucosensing, Hypoglycemia, and the Brain
… these tissues leads to glucose intolerance and insulin resistance, hallmarks of Type 2 diabetes. Within the brain, specialized glucose sensing neurons regulate whole body glucose homeostasis. Unlike GLUT4's role in the periphery, brain GLUT4 regulation of glucose tolerance is not well defined. …
-
Role Of Hyperglycemia, Hypoglycemia, and Glucose Transporter 4 on Brain Glucose Sensing, Counterregulation, and Neuronal Viability
… risk of severe hypoglycemia as occurs with insulin therapy. Thus, understanding how the brain senses and responds to changes in glucose is particularly important to individuals with diabetes. Experiments in this thesis investigated: 1) the role of neuronal glucose transporter 4: GLUT4) in …
-
Tracing of Alpha-to-Beta Cell Transition Following Treatment with CHIR-Injected Human Multipotent Stromal Cell Secreted Proteins
… over 628.6 million people by 2045. Current insulin therapy manages symptoms but cannot restore endogenous beta cell function. Regenerative strategies have demonstrated beta-cell neogenesis following ablation; however, the cellular mechanisms driving islet regeneration remain unclear. …
-
Type 1 diabetes mellitus and the brain: influence of clinical complications and genetic factors on brain structure and cognitive function
… 1 diabetes mellitus is characterised by absolute insulin deficiency, chronic hyperglycaemia and intermittent hypoglycaemia consequent upon treatment with insulin. Severe hypoglycaemia, defined as hypoglycaemia sufficient to necessitate third party intervention for recovery, commonly complicates …
-
Diabetes Education Revisited: Addressing Inpatient Diabetes Care Through An Interactive Educational Video Module For Registered Nurses
<p>Insulin is the most common medication used to treat patients with diabetes in the inpatient setting. Among injectable drugs, insulin has the highest risk for error, which may result in dire consequences for patients. Registered nurses are among the main groups of clinicians that work with …
-
The Role of Interleukin-6 in the Regulation of Glucose Sensing in Hypothalamic GT1-7 Neurons
… is the major complication associated with insulin therapy in type 1 diabetes. Repeated exposure to hypoglycaemia leads to suppression of normal counter regulatory responses (CRR) to subsequent hypoglycaemia, which increases the risk of severe episodes of hypoglycaemia. Studies have …
-
Injectable supramolecular hydrogels for insulin delivery
… 2 diabetes require the delivery of the hormone insulin to maintain appropriate blood glucose concentrations, and current methods involve frequent insulin injections. The key goals for insulin therapy include prolonging release to reduce frequency of injections as well as glucose-responsive …
-
Diabetic retinopathy among patients attending university teaching hospitals adult hospital medical clinic in Lusaka
… Median duration of diabetes was five years with insulin therapy being the most common (115=54.5%) diabetes control measure. Anti-hypertensive medication was being used by 87 participants (40.9%). Median glycated haemoglobin level was high at 8.1%. One hundred sixty-three participants (76.5%) had …
-
Diabetic retinopathy among patients attending university teaching hospitals adult hospital medical clinic in Lusaka
… Median duration of diabetes was five years with insulin therapy being the most common (115=54.5%) diabetes control measure. Anti-hypertensive medication was being used by 87 participants (40.9%). Median glycated haemoglobin level was high at 8.1%. One hundred sixty-three participants (76.5%) had …
-
Mechanism of Metformin Action in Dermal Fibroblasts
… tight euglycemic control and/or intensive insulin treatment, which are associated with increases in hypoglycemia and mortality, but also accelerate wound healing rates, potentially decreasing scarring. Alternatives to insulin therapy include biguanide drugs such as metformin. Metformin …
-
Preparation Of Oligonucleotide Delivery Agents And Insulin Depot Materials Using Solid Phase Synthesis
… studies. siRNA can also be used for gene therapy. However, the use of siRNA for this purpose has not matched its initial promise. One reason for this is that an effective delivery method to enable siRNA to reach the systemic circulation is still lacking. Transfection methods that are …
-
Advancing nursing jurisdiction in diabetes care
… of nursing in relation to the initiation of insulin therapy using a survey approach. Each project is followed by a personal reflection and discussion of the implications in the light of Abbott’s framework. Abbott’s thesis is that the development of professions is determined by a series of …
-
Physiology and pharmacology of diabetes therapies in the cat: insulin detemir, insulin glargine, exenatide and the incretin effect
… disease in cats. Most diabetic cats depend on insulin therapy to survive but traditional insulin formulations are associated with adverse effects and poor compliance. Novel insulin analogs and incretin-based therapies are more effective and have fewer side effects than traditional therapies. We …
-
Molecular mechanisms involved in the regulation of beta-cell viability by Signal Regulatory Protein-Alpha (SIRPα)
… demise, resulting in a requirement for permanent insulin therapy. Pro-inflammatory cytokine pathways, acting via STAT1 and STAT2, contribute to β-cell death whereas anti-inflammatory mechanisms (operating via cytokines such as Interleukin-13 (IL-13)) are downregulated. IL-13 has been shown to …
Page 1 of 2