Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"insulin signaling pathway"”.
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FOXO is the Mediator Linking Temporal Differentiation and the Insulin Signaling Pathway
… development of an organism, because specific pathways can be used reiteratively to differentiate cells. Until recently, the molecular mechanism behind the temporal control of differentiation has remained elusive. Bateman and McNeill (2004) revealed a novel role for the insulin/insulin-like …
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The Roles of the Drosophila Protein Tribbles in Oogenesis and Insulin Signaling Pathway
… kinase proteins that play diverse roles in cell signaling and energy homeostasis. In addition to the central Serine/Threonine kinase domain, members of the Tribbles gene family (Trib) shares C terminal mitogen activated protein kinase kinase MEK1 and E3 ubiquitin ligase COP1 binding motifs, the …
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ER Stress is Linked to the Regulation of Hepatic Gluconeogenesis and Phosphatidylinositol 3-kinase/Akt Signaling Post Burn Injury
… this is due to differential regulation of the insulin signaling pathway in the liver.
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The Potential Role of Insulin (and Stress Response) Pathway Components In Breast Cancer Development and Progression
… cancer progression. We hypothesize that SNPs in insulin-signaling pathway genes, IGF1, TSC1, IGFBP2, IRS1, TCF7L2, IGF1R, and PPARA, if significantly associated with tumor receptor status, provide evidence for a connection between insulin metabolism and the determination of breast tumor subtypes. …
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The Role of Akt2 in Hepatic Lipid Metabolism
Insulin drives the global anabolic response to nutrient ingestion, regulating both carbohydrate and lipid metabolism. When insulin resistance occurs in Type 2 Diabetes Mellitus, dysregulation of both of these processes ensues, resulting in hyperglycemia and lipid abnormalities. One of the most …
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Expression, Cloning, and Sequencing of Putative Insulin Signaling Genes Involved in Diapause in the Flesh Fly <em>Sarcophaga crassipalpis</em>.
… The diapause state has been linked to the insulin signaling pathway. Insulin signaling has been associated with many physiological processes including aging. It is a working hypothesis that the diapause and aging programs have a common set of gene expression pathways via insulin signaling. …
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Beyond the allosteric role of Fructose-2,6-bisphosphate: exploring its effects on gene expression and signal transduction.
In diabetes, insulin is either not available or not effective in suppressing glucose output by the liver. Enhancing hepatic glucose flux through glycolysis by raising fructose-2,6-bisphosphate (F26BP) levels ameliorates the diabetic phenotype in type 1 and type 2 diabetic mouse models (WU et al. …
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Protective effect of TM-25659, known as TAZ activator, on high-fat diet-induced insulin resistance in C57BL/6J mice
… activation of FGF21 level decreases insulin resistance and inflammation in skeletal muscle via GCN2 pathways 1 Ⅰ. INTRODUCTION 2 Ⅱ. MATERIALS AND METHODS 8 A. MATERIALS 9 B. METHODS 10 1. Preparation of PA 10 2. Cell culture 10 3. Immunoblot analysis 11 4. RNA isolation and …
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Induction of Anopheles stephensi nitric oxide synthase by Plasmodium-derived factor(s)
… factors that can induce AsNOS expression and the signaling pathways responsible for transduction in A. stephensi have not been identified until completion of the work described herein. In my studies, I have determined that P. falciparum glycosylphosphatidylinositol (PfGPIs) can induce AsNOS …
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An Investigation Into Splicing Variation and Expression Patterns of Insulin-Like Peptide 4 (ILP4) Within the Drosophila Genus
<p>The insulin-signaling pathway plays a crucial role in regulating metabolic homeostasis in both humans and insects. Dysregulation or mutation within this pathway can lead to various diseases, such as diabetes mellitus and insulin resistance. The insulin-like peptide 4 (ILP4) in Drosophila is an …
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Identification And Rescue Of Misregulated Insulin Signaling In A Drosophila Model Of Fragile X Syndrome
… we show that select expression of dfmr1 in the insulin-producing cells (IPCs) of the brain is sufficient to restore normal circadian behavior and to rescue the memory deficits in the fragile X mutant fly. Examination of the insulin signaling pathway revealed elevated levels of Drosophila …
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Systemic Impact of Insulin-Sensitized Adipocytes and Their Precursors
… over unhealthy, hypoxic adipocyte enlargement. Insulin signaling is central to the development of type 2 diabetes mellitus; resistance within this pathway leads to global metabolic dysfunction and cardiometabolic disease. Downregulation of adipocyte PTEN, a downstream inhibitor of the insulin …
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Investigating IL-15 Metabolic Impact and Its Mechanism of Action in Skeletal Muscle Cells
… are defective in metabolic pathologies such as insulin resistance. For instance, IL-15 increases glucose uptake in muscle and whole-body fatty acid oxidation and its overexpression in skeletal muscle in mice generates a very lean and active phenotype. However, there are discordant reports …
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The interaction between glucose and fat metabolism and insulin resistance in severely burned children and the metabolic effects of fenofibrate
Insulin resistance occurs in conjunction with disturbances in fat and glucose metabolism and mitochondrial dysfunction. Four human studies were conducted to better understand this relationship in the settings of aging and burn trauma. \r\nThe first two studies focused on aging. Insulin resistance …
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Investigating the Effects of Sodium Benzoate on Fat Deposition, Pharyngeal Pumping, and Related Genetic Mechanisms in Caenorhabditis elegans
… dealing with the synthesis of fatty acids, insulin signaling pathway, nuclear hormone receptor, and Krüppel-like zinc finger transcription factors but no significant difference was found in gene expression levels. These results therefore led to the conclusion that sodium benzoate may have …
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A Role for Insulin Signaling in Regulating the PTEN Tumour Suppressor in Caenorhabditis Elegans
… mellitus (T2DM) patients have elevated levels of insulin. Hyperinsulinemia is a major cancer risk factor in T2DM individuals and activated insulin receptor (IR) has been linked to many types of cancer and poor survival. However, the mechanisms that account for the link between the hyper-active …
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Effects of Zinc on the Insulin Receptor and Insulin Signal Transduction Pathway
Zinc is reported to have insulin-like effects. However, the mechanism of these effects still remains unclear. In the present work, the ability of a divalent cation zinc, to modify binding characteristics of the human insulin and type 1 IGF receptors and the insulin intracellular signaling pathway …
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Effect of vasodilation on the response of muscle protein synthesis to insulin in aging
… of muscle proteins to the anabolic action of insulin, even in subjects who do not have diabetes. This alteration impairs the response of older muscle to the anabolic action of a mixed meal, and may contribute to muscle loss with aging. \r\nThe hypothesis is that aging reduces the vascular …
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Non-Canonical Axonal Insulin Receptor Signaling Drives Aversive Olfactory Learning
… to understand C. elegans' changes in molecular pathways, neuronal dynamics, and behavior output mechanics during aversive learning. In Chapter 1, I introduce how studying the neuronal and genetic mechanism of learning in C. elegans can contribute to the understanding of our brains and diseases …
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Effect of benzylglucosinolate on signaling pathways associated with type 2 diabetes prevention
… increase about 50% in the next twenty years. Insulin resistance is one of major features in T2D, which is also a risk factor for metabolic and cardiovascular complications. Epidemiological and animal studies have shown that the consumption of vegetables and fruits can delay or prevent the …
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