Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 122 for “"insulin signaling"”.
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DUSP5 Regulation of Inflammation and Insulin Signaling
Adipose tissue inflammation links obesity to insulin resistance and type 2 diabetes (T2D). Chronic inflammation of adipose tissue is characterized by increased expression of tumor necrosis factor ? (TNF?). TNF? stimulates signaling of mitogen-activated protein kinases (MAPKs) within adipocytes …
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FOXO is the Mediator Linking Temporal Differentiation and the Insulin Signaling Pathway
… and McNeill (2004) revealed a novel role for the insulin/insulin-like growth factor receptor (InR) pathway in regulating the timing of differentiation in neuronal photoreceptor cells in the Drosophila compound eye. The link between the InR pathway and temporal differentiation is significant, …
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The Roles of the Drosophila Protein Tribbles in Oogenesis and Insulin Signaling Pathway
… kinase proteins that play diverse roles in cell signaling and energy homeostasis. In addition to the central Serine/Threonine kinase domain, members of the Tribbles gene family (Trib) shares C terminal mitogen activated protein kinase kinase MEK1 and E3 ubiquitin ligase COP1 binding motifs, the …
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A Role for Insulin Signaling in Regulating the PTEN Tumour Suppressor in Caenorhabditis Elegans
… mellitus (T2DM) patients have elevated levels of insulin. Hyperinsulinemia is a major cancer risk factor in T2DM individuals and activated insulin receptor (IR) has been linked to many types of cancer and poor survival. However, the mechanisms that account for the link between the hyper-active …
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Insulin Signaling & Glucose Metabolism in Glycolytic & Oxidative Muscle of High Fat Fed & Endurance Trained
… significantly high levels of blood glucose and insulin concentrations. These high concentrations were due to the reduction in the activity of key proteins in the insulin-signaling (IS) cascade, leading to blunted rates of glycogen synthesis (GSR) and reduced glucose-6-phosphate (G6P) content in …
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P-REX2 PH Domain Inhibition of PTEN Regulates Transformation, Insulin Signaling, and Glucose Homeostasis
… lost in multiple cancers, antagonizes PI3-kinase signaling by dephosphorylating the second messenger phosphatidylinositol (3,4,5) trisphophate. PTEN expression and enzymatic activity is regulated through various mechanisms, including oxidation, phosphorylation, and protein-protein interactions. …
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Identification And Rescue Of Misregulated Insulin Signaling In A Drosophila Model Of Fragile X Syndrome
… we show that select expression of dfmr1 in the insulin-producing cells (IPCs) of the brain is sufficient to restore normal circadian behavior and to rescue the memory deficits in the fragile X mutant fly. Examination of the insulin signaling pathway revealed elevated levels of Drosophila …
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The effect of lifestyle modification on the insulin-signaling cascade among subjects with impaired glucose tolerance
… glucose tolerance(IGT) is characterized by insulin resistance and lifestyle modification is considered to have positive effects on glycemic control and reducing the risk of diabetes. Recently, defects in the insulin-signaling cascade, especially PI-3 kinase pathway, have been implicated in …
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Determining the effect of lipid nanoemulsions on insulin signaling and the inflammatory pathways at the Blood-Brain Barrier
… Alzheimer’s Disease (AD)(1). As the brain is an insulin-sensitive organ and requires insulin for promoting neuronal integrity and function, impairment of insulin signaling in the CNS has huge implications for memory and cognition(2). Hyperinsulinemia observed in AD and T2DM contributes to …
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Studies on the mechanism of insulin signaling reduction in high glucose/palmitate-induced INS-1 beta cell death
… 포도당과 지방산에 의한 IRS-1 tyrosine 기 감소의 원인 4 1. IR (insulin receptor) 에 의한 IRS-1 tyrosine기 인산화 감소 4 2. IRS-1 Serine 인산화가 증가시킴으로 인해 IRS-1 tyrosine 인산화 를 감소 5 3. PTPs에 의해서 IRS-1 tyrosine 인산화가 감소 7 D. IKK 10 E. 연구 목적 13 Ⅱ. 재료 및 방법 (혹은 연구대상 및 방법) 14 A. 재료 14 1. 재료 14 B. 방법 16 1. 세포주 및 세포주 배양 16 2. MTT …
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Expression, Cloning, and Sequencing of Putative Insulin Signaling Genes Involved in Diapause in the Flesh Fly <em>Sarcophaga crassipalpis</em>.
… The diapause state has been linked to the insulin signaling pathway. Insulin signaling has been associated with many physiological processes including aging. It is a working hypothesis that the diapause and aging programs have a common set of gene expression pathways via insulin signaling. …
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An insulin-like peptide regulates size and adult stem cells in planarians
… to nutritional cues. We explore the role of insulin signaling in S. mediterranea. We disrupt insulin signaling via RNA interference and show that animals, despite eating, degrow similarly to starved animals. Utilizing in situ hybridization and immunofluorescence, we assess cellular changes in …
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PMI 5011 regulates the ubiquitin proteasome system in skeletal muscle
Insulin resistance in type 2 diabetes is associated with impaired glucose and protein metabolism in skeletal muscle. The impaired insulin signaling in skeletal muscle affects muscle mass by tilting the balance between skeletal muscle protein synthesis and degradation toward degradation, a process …
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Systemic Impact of Insulin-Sensitized Adipocytes and Their Precursors
… over unhealthy, hypoxic adipocyte enlargement. Insulin signaling is central to the development of type 2 diabetes mellitus; resistance within this pathway leads to global metabolic dysfunction and cardiometabolic disease. Downregulation of adipocyte PTEN, a downstream inhibitor of the insulin …
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Investigating the role of estrogen deprivation and diet-induced insulin resistance on markers of amyloid-β production and degradation in the brain
… Disease (AD). Furthermore, diet-induced insulin resistance has also been shown to increase Aβ; however, whether this process is exacerbated with the loss of estrogen remains unknown. We aimed to investigate the effects of estrogen loss on amyloid production and degradation pathways, as …
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The Effects of Low Dose Endotoxin on Glucose Homeostasis
… individuals, which is associated with insulin resistance. One factor hypothesized to contribute to increased inflammation in obese and diabetic states is elevated blood endotoxin levels, also known as metabolic endotoxemia. In healthy rodents (non-obese and insulin sensitive), there is …
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Altered Expression of Metabolic Proteins Contributes to Neuropathological Disease
… studies suggest that both hyper- and hypoinsulinemia are associated with an increased risk for developing AD. Indeed, insulin signaling is altered in post-mortem brain tissue from AD patients and insulin and treatments known to enhance insulin signaling, can improve cognitive function. …
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Protective effect of TM-25659, known as TAZ activator, on high-fat diet-induced insulin resistance in C57BL/6J mice
… activation of FGF21 level decreases insulin resistance and inflammation in skeletal muscle via GCN2 pathways 1 Ⅰ. INTRODUCTION 2 Ⅱ. MATERIALS AND METHODS 8 A. MATERIALS 9 B. METHODS 10 1. Preparation of PA 10 2. Cell culture 10 3. Immunoblot analysis 11 4. RNA isolation and …
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Molecular analysis of insulin action using high throughput genetic screens
The insulin-stimulated uptake of glucose by muscle and adipose is vital for the maintenance of glucose homeostasis in the body. This uptake primarily occurs through the action of the insulin-regulatable glucose transporter GLUT4, which is rapidly translocated to the plasma membrane in response to …
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