Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"insulin resistant"”.
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Cardiovascular risk reduction in insulin resistant states
Introduction: Insulin resistance is the hall mark of a number of pathological conditions and is thought to play a major role in the cardiovascular risk associated with them. This thesis critically evaluates two insulin resistant conditions - polycystic ovary syndrome (PCOS) and type 2 diabetes …
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Pharmacokinetics and effect of pioglitazone in obese, insulin-resistant cats
Pioglitazone is a thiazolidinedione (TZD) insulin sensitizer approved for use in human type 2 diabetes mellitus. In addition to improving glycemic control, lipid profiles, and pancreatic β-cell function in diabetics, pioglitazone decreases hepatic triglyceride content in humans with non-alcoholic …
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Cardiovascular effects of insulin: studies in normal and insulin resistant subjects
Contains fulltext : mmubn000001_237863731.pdf (Publisher’s version ) (Open Access)
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Impact of saskatoon berry powder on metabolism and gut microbiota in diet-induced insulin resistant mice
… are characterized by low-grade inflammation and insulin resistance, and are usually accompanied with alteration in the gut microbiota profile. Evidence in recent decades shows that the gut microbiota plays a significant role in the development of metabolic syndromes, and obese individuals have …
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Impact of Glycemic Therapy on Myocardial Sympathetic Neuronal Integrity and Left Ventricular Function in Insulin Resistant Diabetic Rats: Serial Evaluation by 11C-meta-Hydroxyephedrine Positron Emission Tomography
… mellitus, presence of hyperglycemia, and/or insulin resistance confer cardiovascular risk, particularly for diastolic dysfunction. Diabetes is associated with elevated myocardial norepinephrine (NE) content, enhanced sympathetic nervous system (SNS) activity, altered resting heart rate, and …
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Characterization of an assay of insulin mediator activity on pyruvate dehydrogenase in liver tissue and its application in the study of the insulin resistant obese Zucker rat
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Bioactive peptides from purified and digested adzuki bean (Vigna angularis) β-vignin on type-2 diabetes-related pathways: effect and mechanism of action in a liver model under healthy and insulin-resistant states
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2027-08-01
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Metabolic Bioactivity of Athrixia phylicoides
BACKGROUND: Insulin resistance is a major risk factor for the development of type 2 diabetes (T2D). It is characterized by insufficient response to secreted insulin in target tissues. In vitro studies demonstrated the ability of an aqueous extract of Athrixia phylicoides to increase glucose uptake …
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Aspects of the interrelation between hypertension and insulin resistance: A preliminary study
… percent of all hypertensive patients are also insulin resistant. Both hypertension and insulin resistance are again risk factors for other cardiovascular diseases such as atherosclerosis and heart fai lure. The nature of the association between hypertension and insulin resistance has not heen …
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Metabolic lipid regulation during developmental stress : fatty acid dynamics in fasting northern elephant seals.
… (NES) (Mirounga angustirostris) is a temporally insulin resistant, deep-diving marine mammal reliant on fatty acid oxidation during seasonal fasting. Over the fast, NES females and weaned pups were found to oppositely utilize monounsaturated and saturated fatty acids, while polyunsaturated fatty …
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Insulin resistance, chronic heart failure and potential treatment
Diabetes Mellitus (DM) and insulin resistant (IR) are highly prevalent among heart failure (HF) patients. There is now increasing evidence to suggest a bidirectional relationship between IR and HF. DM and IR not only lead to heart failure, but heart failure can also lead to the development of DM or …
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Characterisation of the role of mitochondrial dysfunction and meta-inflammation as a shared pathogenic network in gestational diabetes mellitus
… pathology is considered a state of exaggerated insulin resistance in pregnancy, mediated by pancreatic beta cell insufficiency, adipose dysregulation and systemic meta-inflammation. Although the pathophysiology of GDM is complex, adipose tissue dysfunction is an established cause of metabolic …
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Serum Omentin As A Potential Biomarker For Complex Atypical Hyperplasia and Endometrioid Endometrial Adenocarcinoma
… in lower levels in patients who are obese and/or insulin resistant. A case-control study was conducted using the serum of 140 women with endometrial cancer and 75 women with endometrial hyperplasia who were matched 1:1 based on body mass index (BMI) and menopausal status to women with no history …
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Genomic analysis of hepatic insulin resistance
… a genetically complex disease characterized by insulin resistance in peripheral tissues, which results in simultaneous hyperglycemia and hyperinsulinemia. Because of the prevalence of type II diabetes, many researchers are investigating the genetics of glucose homeostasis, however, traditional …
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Reactive oxygen species play a causal role in multiple forms of insulin resistance
Insulin resistance is a cardinal feature of type 2 diabetes and is characteristic of a wide range of other clinical and experimental settings. Little is known about why insulin resistance occurs in so many contexts. Do the various insults that trigger insulin resistance act through a common …
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Flavonol kaempferol in the regulation of glucose homeostasis in diabetes
… Type 2 diabetes (T2D) is a result of chronic insulin resistance (IR) and loss of β-cell mass and function. Therefore, the search for naturally occurring, low-cost, and safe compounds that could enhance insulin sensitivity and protect functional β-cell mass can be an effective …
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Inhibition of Free fatty acid-Induced Insulin Resistance by Rosemary Extract: Investigation of the Mechanisms Involved
… fatty acids (FFA) are highly associated with insulin resistance and are a major risk factor for the development of type 2 diabetes mellitus. This thesis investigates the effect of rosemary extract and rosemary extract polyphenols carnosic acid (CA), rosmarinic acid (RA) and carnosol (COH) on …
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EFFECTS OF BEETROOT JUICE, PROTEIN SUPPLEMENTATION, AND RESISTANCE TRAINING ON STRENGTH IN OLDER ADULTS
… in muscle strength, lean body mass, and insulin sensitivity occur with aging; a novel intervention of dietary nitrates, protein supplement, and resistance training was tested to improve these age-related declines. Beetroot juice is a dietary source high in nitrates. PURPOSE: The primary …
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Mapping And Directing Branched-Chain Amino Acid Metabolism In Health And Insulin Resistance
… in skeletal muscle of healthy mice. While insulin acutely increases BCAA oxidation in cardiac and skeletal muscle, chronically insulin-resistant mice show blunted BCAA oxidation in adipose tissues and liver, shifting BCAA oxidation toward muscle. Pharmacologic activation of BCAA oxidation …
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Genetic and Metabolic Markers for the Development of Diabetes after Gestational Diabetes Mellitus
… to characterize these women according to insulin secretion, insulin sensitivity, autoimmunity and genetics; and to identify possible markers and predictors for the development of manifest diabetes. The subjects were recruited through a regional screening programme in which oral glucose …
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