Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 467 for “"insulin resistance"”.
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Myocardial insulin resistance in experimental uraemia
… Progression of LVH leads to the development of insulin resistance, a feature common to CKD and heart failure, further jeopardising survival of the uraemic heart.The aim of this thesis was to investigate the effect of uraemia on cardiac physiology, function and metabolism. Specifically, the aim …
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Genomic analysis of hepatic insulin resistance
… a genetically complex disease characterized by insulin resistance in peripheral tissues, which results in simultaneous hyperglycemia and hyperinsulinemia. Because of the prevalence of type II diabetes, many researchers are investigating the genetics of glucose homeostasis, however, traditional …
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Transcriptional regulation of adipose insulin resistance
Insulin resistance is a condition that underlies type 2 diabetes and various cardiovascular diseases. It is highly associated with obesity, making it a pressing medical problem in face of the obesity epidemic. The obesity association also makes adipose tissue the target of interest for ongoing …
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Treating type 2 diabetes through insulin resistance
… by hyperglycaemia and the diverse effects of insulin resistance. Obesity, in particular central obesity, is a strong pre-disposing factor for type 2 diabetes. Skeletal muscle is the main site of insulin-stimulated glucose disposal and appears to be the first organ that becomes insulin …
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Insulin resistance in cancer cachexia and metabolic syndrome
… MetS and CC share several common issues such as insulin resistance and low-grade inflammation. In these scenarios, tissue macrophages act as key players, due to their capacity to produce and release inflammatory mediators. One of the main features of MetS is hyperinsulinemia, which is generally …
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Pharmacological modulation of insulin resistance - benefits and harms
… have been advocated as second or third line insulin sensitizing agents in the management of type 2 diabetes (T2DM). Their widespread use has been hampered by concerns about their cardiovascular safety, including fluid retention. Metformin is established as first-line glucose-lowering …
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Insulin resistance, chronic heart failure and potential treatment
Diabetes Mellitus (DM) and insulin resistant (IR) are highly prevalent among heart failure (HF) patients. There is now increasing evidence to suggest a bidirectional relationship between IR and HF. DM and IR not only lead to heart failure, but heart failure can also lead to the development of DM or …
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Systems biology of diet-induced hepatic insulin resistance
… is a world-wide health crisis that promotes insulin resistance and type 2 diabetes. Obesity increases intracellular free fatty acid concentrations in peripheral tissues, particularly the liver, which disrupts molecular mechanisms that maintain normal glycemia in response to fasting and …
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Therapeutic Approaches to Insulin Resistance and Type 2 Diabetes
… disorder primarily caused by a systemic insulin resistant state to which obesity is a major contributor. Increasing visceral adipose tissue augments adipokine secretion provoking an enduring low-grade inflammatory response that negatively impacts on the insulin signalling cascade. In an …
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Association of Fat Oxidation and Insulin Resistance in Prepubertal Children
… the relationship between fat oxidation and insulin resistance (IR) may provide vital clues to the mechanisms behind the development of metabolic disease in prepubertal children. The purpose of this study was to examine the association of fat oxidation with insulin resistance (IR) and insulin …
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Molecular Mechanism of Insulin Resistance: Role of mTOR Signaling Pathways
In Chapter IV, I describe another investigation of mTOR signaling mechanisms. In this study I initially set out to identify nuclear export signals in mTOR. A systematic scan of the mTOR sequence revealed 16 peptides conforming to the canonical leucine-rich nuclear export signal, of which 3 were …
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The regulation of ceramide content and insulin resistance in skeletal muscle
Insulin resistance is commonly developed in obesity and is a trait of the beginning stage of type 2 diabetes mellitus (DM). It is highly likely that the high plasma fatty acid levels provoke the condition in the obese and insulin resistant state of type 2 DM. Hence, the purpose of this study was to …
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Genomic and metabolomic interrogation of body composition and insulin resistance endotypes
… in which the complex metabolic interplay among insulin-sensitive tissues can go awry. Current clinical classification remains imprecise, however, relying on broad constructs (obesity, type 2 diabetes, BMI thresholds) that do not reliably distinguish underlying mechanisms. One way to inform …
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Insulin Resistance and Inflammation in Neurodegeneration: Lessons from in vitro Models
… linked. Both share common etiologies such as insulin resistance (IR) and chronic inflammation. While it was once believed that the brain was not susceptible to the peripheral environment, it has now been demonstrated that systemic conditions impact the brain, especially so in metabolic …
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The Genetics of Differential Fat Distribution: The Insulin Resistance Atherosclerosis Family Study
… compared to European-derived cohorts. The Insulin Resistance Atherosclerosis Family Study (IRASFS) is a well phenotyped cohort with measures of glucose homeostasis and adiposity for 1,424 Hispanic Americans (HA) and 604 African Americans (AA). In particular, the study includes …
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Aspects of the interrelation between hypertension and insulin resistance: A preliminary study
… percent of all hypertensive patients are also insulin resistant. Both hypertension and insulin resistance are again risk factors for other cardiovascular diseases such as atherosclerosis and heart fai lure. The nature of the association between hypertension and insulin resistance has not heen …
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Anti-Insulin Resistance Treatments Suppress Her2+ Breast Cancer Growth Via Altering Metabolism
… previous finding in patients showed that anti-insulin resistance treatments are associated with improved HER2<sup>+</sup> breast cancer survival of diabetic women. However, there were no transgenic mouse models to study the correlation and explain the detailed mechanism. We generated a mouse …
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