Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 91 for “"insulin receptor"”.
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Non-Canonical Axonal Insulin Receptor Signaling Drives Aversive Olfactory Learning
… diseases of the brain. I briefly describe how insulin and insulin-like growth factor pathways regulate learning in humans and other mammals. In Chapter 2, I explore and refine the stimulation conditions that decrease or enhance C. elegans's attraction to butanone. I separate the effect of odor …
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Role of the insulin receptor substrate (IRS) proteins in the adipose cell
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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The Influence of Ovarian Sex Steroids on Insulin Receptor Status in Mice
… hypoglycaemic action of exogenously administered insulin was significantly increased in mice at oestrus compared to mice at dioestrus, two stages of the oestrous cycle which represent high and low plasma concentrations of the ovarian sex steroids respectively. Unchanged insulin binding data …
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The effect of oral-hypoglycaemic drugs and obesity on insulin receptor binding
This thesis is concerned with the regulation of insulin receptors, with respect to receptor number, affinity and certain postreceptor effects of insulin action. The Aston obese hyperglycaemic (ob/ob) mouse was used as an animal model of obesity and type 2, NID diabetes mellitus. Hepatocyte insulin …
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Effects of Zinc on the Insulin Receptor and Insulin Signal Transduction Pathway
Zinc is reported to have insulin-like effects. However, the mechanism of these effects still remains unclear. In the present work, the ability of a divalent cation zinc, to modify binding characteristics of the human insulin and type 1 IGF receptors and the insulin intracellular signaling pathway …
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Exploring a Nuclear Insulin Receptor Signalling Pathway in Drosophila Neural Stem Cells
The insulin receptor (InR) is a central regulator of metabolism, growth, and proliferation in both humans and *Drosophila*. Integrating a range of signals, InR coordinates pleiotropic, tissue‐specific outputs. Neural stem cells (NSCs) give rise to the vast range of cell types that comprise the …
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Submonomer Synthesis and Structure-activity Relationship Studies of Azapeptide Inhibitors of the Insulin Receptor Tyrosine Kinase
… high affinity and selective binding to a target receptor or enzyme in order to modulate its activity for therapeutic purpose. Moreover, azapeptides have been found to be stable in biological media thereby improving their therapeutic indices and pharmacokinetic properties. For example, Goserelin, …
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EFA6/PSD3, Arf6 Modulator, Regulates Ethanol-Induced Behaviors Via the Insulin Receptor Signaling Pathway in Flies and Humans
… on the body, absence of a known high affinity receptor to ethanol, and large phenotypic heterogeneities, which have been shown in genome wide association studies (GWAS). In the United States alone, AUD are highly prevalent with approximately ~18 million adults aged 18 and up and ~1 million …
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Insulin Receptor Substrate-1 Serine Phosphorylation by a Novel Phosphatidylinositol-3'-Kinase-Associated Serine Kinase Regulates Insulin and Interferon Receptor Signaling
… and reduce its ability to act as a substrate for insulin and interferon alpha (IFNalpha) receptors. PI 3-kinase is shown to associate with a wortmannin insensitive 76 kDa serine phosphoprotein (pp76) distinct from the p85 subunit of PI 3-kinase. pp76 is phosphorylated by an okadaic acid sensitive, …
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Insulin Modulates Synaptic Transmission and AMPA Receptor Trafficking Via Insulin Receptor Signaling Molecule In Region CA1 of the Juvenile and Mature Hippocampuss
<p>Several studies have shown that insulin induces synaptic plasticity in the hippocampal formation. In particular, it has been shown that insulin produces long term depression (LTD) in region CA1 of the juvenile and mature rat hippocampus. Using western blot analysis and field potential slice …
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Genetic mapping and functional studies of a natural inhibitor of the insulin receptor tyrosine kinase: the mouse ortholog of human [alpha subscript 2]-HS glycoprotein
… inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR). In this study we report the identification, cloning, and characterization of the mouse Ahsg gene and its function as an IR-TK inhibitor. Genomic clones derived from a mouse Svj 129 genomic library were sequenced in order to …
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Non-autonomous regulation of bone mass accrual and the role of T-cell protein tyrosine phosphatase in the bone regulation of insulin sensitivity
… releasing the hormone osteocalcin that increases insulin secretion and sensitivity in the pancreas and testosterone production in the Leydig cells of the testis. In my thesis study, I explore both the cell-nonautonomous regulation of osteoblast differentiation and the bone regulation of energy …
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Molecular Mechanisms by which a Grape Seed Procyanidin Extract Modulates Glucose Homeostasis
… to maintain metabolic homeostasis. The hormone insulin, after binding to the insulin receptor, initiates a well-established controlled metabolic signaling cascade that consequently lowers blood glucose levels. There is considerable interest regarding effective natural therapies for combating …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
… and impaired signaling mediated by the insulin receptor and insulin-like growth factor 1 (IGF1) receptors underlies the pathogenesis of intellectual disability. NCAM2 is enriched at excitatory synapses and is involved in synapse maturation and maintenance. The role of NCAM2 in the …
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Regulation of Nutrient Metabolism in Equine Skeletal Muscle and Adipose Tissue
… metabolism is evidenced by the development of insulin resistance and increased fasting plasma insulin concentrations (hyperinsulinemia) while altered lipid metabolism is evidenced by increased plasma lipid concentrations. Obesity in horses also increases the risk of the painful hoof disease, …
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The Effect of Weight Reduction on Chronic Inflammatory Molecules and Insulin Resistance in type 2 DM
Type 2 Diabetes mellitus(DM) is characterized by insulin resistance. Recently, defects in the insulin-signaling cascade have been implicated in the pathogenesis of insulin resistance. Also obesity is a metabolic disease and insulin resistance is a pathogenesis of obesity. So obesity is correlated …
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Optimisation of the Investigation of Antibody-Mediated Dysglycaemia
Two rare and severe disorders of insulin action, namely insulin autoimmune syndrome (IAS) and type B insulin resistance (TB-IR), are caused by pathogenic antibodies against insulin or the insulin receptor, respectively. These may arise in isolation or may complicate management of pre-existing …
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Engineering of Nonviral Vectors for Gene Therapy
… By applying a hydrophobic analog of human insulin to the cyclodextrin polyplexes, I was able demonstrate a 2--3 fold enhancement in transfection efficiency in insulin receptor-rich cell lines.
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Chronic prenatal ethanol exposure produces neurobehavioural and metabolic dysfunction in guinea pig offspring
… multi-faceted and could involve alterations in insulin and insulin-like growth factor (IGF) signaling pathways. These pathways are not only important for metabolism, but are also involved in CNS neuronal survival and plasticity, which are impaired by CPEE. The overall goal of this thesis …
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