Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"insulin pump therapy"”.
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Efficacy and Feasibility of Fully Automated Closed Loop Insulin Pump Therapy after Islet Auto-Transplantation
… islet apoptosis during engraftment. Closed Loop therapy may improve glycemic control in this population. Methods: Analysis of 14 patients (36% male; age 35.9±11.4 years) at transition from IV to subcutaneous insulin (POD=6±1.4 days). Subjects were block randomized to CL pump (n=7) or multiple …
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Carbohydrate Supplementation During Prolonged Aerobic Exercise for People Living with Type 1 Diabetes on Insulin Pump Therapy: The ExCarbs Study
… diabetes. This thesis assessed carbohydrate and insulin strategies during 120-min fasted exercise (~45% VO2peak) in fifteen individuals with type 1 diabetes. The strategies performed in randomized crossover design included: 1) carbohydrates of 0.3 g/kg/hr; 2) 50% basal rate reduction 90-min …
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The effect of protein and fat meal content on the insulin requirement of type 1 diabetic children
… a major challenge. Determining meal bolus insulin is mainly dependent on carbohydrate counting and the carbohydrate content of a meal. Recent studies have shown this method to be ineffective at times. Also, it has been proven that the fat and protein contents of meals demand insulin as …
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Continuous Subcutaneous Insulin Infusion in Comparison to Subcutaneous Insulin Injections in the Preschooler with Type 1 Diabetes Mellitus
… that results from autoimmune destruction of insulin-producing beta cells of the pancreas subsequently causing a lack of insulin and leading to increased blood and urine glucose (Cihakova, 2001). Type 1 diabetes has increased at an alarming rate in very young children (Weinzimer et al., 2004). …
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The impact of closed-loop insulin delivery on glucose control in children and young people with type 1 diabetes mellitus: Longer-term benefits across the paediatric age-spectrum
… and is characterised by a deficiency of insulin caused by immune-mediated destruction of pancreatic beta cells in genetically predisposed individuals. Despite increasing technology use to manage type 1 diabetes, most children struggle to meet treatment guidelines for target glycated …
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The impact of high and intermittent-high glucose on ROS generation and bioenergetic metabolism in vascular endothelial cells
… from a clinical study of T2DM patients receiving insulin pump therapy.<br/>High glucose significantly increased both general and mitochondrial superoxide generation in HUVECs, whereas intermittent-high glucose did not. High glucose also increased the total NAD+/NADH ratio and appeared to elicit …
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Closed-loop insulin delivery in adults with type 1 diabetes
… 1 diabetes with currently available methods of insulin delivery is challenging. Aggressive regimens carry an increased risk of hypoglycaemia, particularly overnight. Both alcohol consumption and exercise predispose further to low glucose levels. The demands are even greater in pregnancy where, …
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The Artificial Pancreas in Children and Adolescents with Type 1 Diabetes: Bringing Closed-Loop Home
… ongoing development of more physiological insulin preparations, recent advancements in insulin pump technology and more accurate blood glucose monitoring, in clinical practice it remains challenging to achieve normoglycaemia whilst reducing the risk of hypoglycaemia, particularly in young …
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Propuesta de un algoritmo de control en lazo cerrado para la diabetes tipo 1
… por la insuficiente o nula producción de insulina o la reducida sensibilidad a esta hormona. Es una enfermedad crónica con una mayor prevalencia en los países desarrollados debido principalmente a la obesidad y la vida sedentaria. La diabetes Tipo 1 es una enfermedad autoinmune en la que …