Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 32 for “"insulin delivery"”.
-
Injectable supramolecular hydrogels for insulin delivery
… 1 and subsets of Type 2 diabetes require the delivery of the hormone insulin to maintain appropriate blood glucose concentrations, and current methods involve frequent insulin injections. The key goals for insulin therapy include prolonging release to reduce frequency of injections as well as …
-
Novel polyelectrolyte complexes for oral insulin delivery.
Oral delivery of insulin used for the management of Type 1 diabetes could be referred to as one of the major long-term goals of diabetes research. However, the bioavailability of orally-administrered insulin is significantly compromised by enzymatic degradation in the GI tract, and poor enteral …
-
Glucose-responsive materials for self-regulated insulin delivery
… after subcutaneous injection of commercial insulin. Glucose- regulated insulin delivery (GRID) would vastly improve glycemic control while reducing (i) the required frequency of subcutaneous injections and finger-stick glucose tests, (ii) the incidence of hypoglycemia and hyperglycemia, and …
-
Glass siliconization process characterization for insulin delivery device performance
… siliconization of glass cylinders, primary insulin containers, is a manufacturing process that is critical to the performance of drug delivery devices. Delivery devices are evolving and placing additional burden on production processes. Variability in siliconization and baking processes …
-
Closed-loop insulin delivery in adults with type 1 diabetes
… 1 diabetes with currently available methods of insulin delivery is challenging. Aggressive regimens carry an increased risk of hypoglycaemia, particularly overnight. Both alcohol consumption and exercise predispose further to low glucose levels. The demands are even greater in pregnancy where, …
-
InsulPatch: A Slim, Powerless Microfluidic Patch-Pump for Insulin Delivery
… an oral pathway and that require transdermal delivery. The patch-pump is a promising replacement for conventional syringes and battery-powered pumps because it is slim, powerless, painless, and relatively inexpensive. The majority of this thesis focuses on the fabrication and testing of …
-
Synthesis and characterisation of fluorescent FITC-insulin glulisine conjugates for insulin delivery
Drug development and its delivery have always been a pioneering area of research for the application and understanding of modern bioanalytical problems. The biodistribution of the drug, along with its stability and metabolism within biological systems, has been of prime importance in pharmaceutical …
-
Analysis of randomly occurring high injection forces in an insulin delivery device
… action. However, as production numbers of an insulin injection device pass 200 million per year, testing continues to find sub-assemblies with too-high injection forces, seemingly at random. Up until now, no corrective action has been effective in preventing these problems. These …
-
Investigation into reliability and performance of an implantable closed-loop insulin delivery device
An implantable closed-loop insulin delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of 10 years, to mimic pancreas. In this thesis, the reliability and performance capability of the INsmart device was studied …
-
Development and evaluation of glucose-responsive biomaterials as self-regulated insulin delivery systems
… multiple daily doses of exogenous insulin to combat hyperglycemia To reduce this patient burden, limit the occurrence of hypoglycemic events, and better mimic native insulin activity, therapies which can self-regulate insulin delivery are an attractive option This work begins to …
-
Fracture healing : the effects of local insulin delivery via calcium sulfate and tricalcium phosphate
… studies have documented the major role played by insulin in osseous healing. This is the first study to examine local intramedullary insulin delivery to the fracture site and its effect upon the normal fracture healing process. Preceding results show that when administered at the fracture site of …
-
Synthesis, Characterization and In-vivo Testing of Photoactivatable Insulin Depots for Continuously Variable and Minimally Invasive Insulin Delivery
… The stability of these macromolecules, their delivery, and penetration inside the cells have been the main hurdles limiting their true potential. In the dissertation, various strategies to overcome such protein delivery challenges are discussed. Insulin is a lifesaving peptide for millions of …
-
The impact of closed-loop insulin delivery on glucose control in children and young people with type 1 diabetes mellitus: Longer-term benefits across the paediatric age-spectrum
… and is characterised by a deficiency of insulin caused by immune-mediated destruction of pancreatic beta cells in genetically predisposed individuals. Despite increasing technology use to manage type 1 diabetes, most children struggle to meet treatment guidelines for target glycated …
-
The Artificial Pancreas in Children and Adolescents with Type 1 Diabetes: Bringing Closed-Loop Home
… ongoing development of more physiological insulin preparations, recent advancements in insulin pump technology and more accurate blood glucose monitoring, in clinical practice it remains challenging to achieve normoglycaemia whilst reducing the risk of hypoglycaemia, particularly in young …
-
Glycaemic control in pregnancies complicated by type 1 diabetes
… I present the first home studies of closed-loop insulin delivery in this population. The aim of these studies was to assess the feasibility, efficacy, and utility of overnight and then day-and-night closed-loop insulin delivery in pregnant women with type 1 diabetes. The overnight study, which …
-
DEVELOPMENT OF MICRONEEDLES ON FLEXIBLE SKIN PATCH WITH FUNCTIONAL COMPONENTS FOR TRANSDERMAL DRUG DELIVERY APPLICATIONS
… and functions for transdermal drug delivery applications. Here we developed a very unique technology called drawing lithography for the assembly of SU-8 and maltose sharp tips at the final step of the fabrication process, which is compatible with most of the conventional thin film …
-
Somatic cell gene therapy for diabetes mellitus: engineering a surrogate B-cell
Improved methods of insulin delivery are required for the treatment of insulin-dependent diabetes mellitus (IDDM) to achieve a more physiological profile of glucose homeostasis. Somatic cell gene therapy offers the prospect that insulin could be delivered by an autologous cell implant, engineered …
-
Linear Modeling and Prediction in Diabetes Physiology
… regulate the blood glucose level due to insulin deficiency or resistance, leading to serious health damages. The therapy is essentially based on insulin injections and depends strongly on patient daily decisions, being mainly based upon empirical experience and rules of thumb. The …
-
Modeling and Prediction in Diabetes Physiology
… making concerning the most adequate choice of insulin delivery, meal intake and exercise, to help diabetic subjects maintaining glycemia as close to normal as possible. The approaches taken to describe the glucose metabolism were discrete-time and continuous-time models on input-output form and …
-
Overcoming Diffusion Limitations in Encapsulated Cell Therapy for Type 1 Diabetes
… by the body’s inability to produce sufficient insulin to properly regulate blood glucose levels. Despite advances in glucose monitoring/insulin delivery systems, the pancreatic islet is still functionally superior at regulating blood glucose levels. Pancreatic islet transplantation requires …
Page 1 of 2