Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"insulin deficiency"”.
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Metabolic studies in acute insulin deficiency
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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An Investigation of the Role of Insulin Deficiency and Loss of PI3K-Akt Signaling Downstream Regulators GSK3β -CREB Signaling in the Pathogenesis of the Diabetic Brain
… brain, and our lab has shown that replacement of insulin in the brain via intranasal delivery prevents diabetes mellitus (DM) mediated neurodegeneration. Insulin is speculated to act through activation of PI3K-Akt signaling. We hypothesized that the neurodegenerative changes and cognitive …
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Type 1 diabetes mellitus and the brain: influence of clinical complications and genetic factors on brain structure and cognitive function
… 1 diabetes mellitus is characterised by absolute insulin deficiency, chronic hyperglycaemia and intermittent hypoglycaemia consequent upon treatment with insulin. Severe hypoglycaemia, defined as hypoglycaemia sufficient to necessitate third party intervention for recovery, commonly complicates …
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Linear Modeling and Prediction in Diabetes Physiology
… regulate the blood glucose level due to insulin deficiency or resistance, leading to serious health damages. The therapy is essentially based on insulin injections and depends strongly on patient daily decisions, being mainly based upon empirical experience and rules of thumb. The …
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DIABETES IN PALEOPATHOLOGY: NEW METHODS AND APPLICATIONS
… is characterized by hyperglycemia because of insulin deficiency or insulin resistance. Type 2 diabetes is the most common type of diabetes. Although symptoms of diabetes have been documented throughout history, the effects of diabetes on bone are indirect and not well understood. At least …
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The effects of aerobic and resistance exercise on inflammatory markers and metabolic control in healthy individuals and type 1 diabetics using either insulin pump or multiple dose injection
… 1 diabetes (T1D) is characterised by an absolute insulin deficiency resulting from the chronic and progressive destruction of pancreatic β-cells by the immune system cells. Continuous subcutaneous insulin infusion (CSII) is becoming a popular technique for insulin delivery among T1D patients. …
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Mechanisms Of Cytokine-Induced Metabolic Dysfunction Of The Pancreatic Beta-Cell
… I diabetes is characterized by an absolute insulin deficiency due to loss of pancreatic â-cell mass by autoimmune aggression. During the progression of the disease proinflammatory cytokines such as IL-1â, TNFá and INFã are secreted by infiltrated and activated T-cells and macrophages which …
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Effects of naringenin on glucose uptake in L6 skeletal muscle cells
Diabetes mellitus is a disorder of inadequate insulin action and consequent high blood glucose levels. Type 2 diabetes accounts for the majority of cases of the disease and is characterized by insulin resistance and relative insulin deficiency resulting in metabolic deregulation. It is a complex …
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Genetic contribution to type 1 diabetes microvascular complications
… of beta cells in the pancreas resulting in insulin deficiency, which leads to hyperglycemia and organ damage. T1D patients experience an increased risk of morbidity and mortality due to long-term complications, specifically retinopathy, nephropathy, and neuropathy. Studies demonstrating …
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Cellular Mechanism of High Glucose/Palmitate-induced INS-1 Beta Cell Death
… to the development of type 2 diabetes. A deficiency of insulin through loss of beta cell mass, and subsequent impaired compensation against insulin resistance is believed to be a pathogenic cause of type 2 diabetes. Pancreatic β-cell mass is regulated by at least four independent …
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Physiological, Morphological and molecular biological studies of the effect of Glucagon-like peptide-1 and exenatide in the diabetic rat pancreas
… neuropathy and cardiomyopathy. DM is due to a deficiency of insulin or insulin resistance. Of the 225 million diabetic patients, around 5-10% suffer from type 1 DM (T1DM) and the remaining 90-95% suffer from type 2 diabetes (T2DM). T1DM is due to insulin deficiency whereas T2DM is due to either …