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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"insulin action"”.
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Quantitative Studies on Insulin Action
Made available in DSpace on 2014-12-05T19:37:39Z (GMT). No. of bitstreams: 1 6101593.pdf: 4060428 bytes, checksum: 64f0e56ec1ef39370b79f8b29654ad26 (MD5) Previous issue date: 1961
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Molecular analysis of insulin action using high throughput genetic screens
The insulin-stimulated uptake of glucose by muscle and adipose is vital for the maintenance of glucose homeostasis in the body. This uptake primarily occurs through the action of the insulin-regulatable glucose transporter GLUT4, which is rapidly translocated to the plasma membrane in response to …
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Dynamic subcellular proteomics identifies novel regulators of adipocyte insulin action
Insulin acts on adipocytes to control whole-body lipid and glucose metabolism. Following binding to its receptor on adipocytes, insulin activates a signalling cascade that promotes glucose uptake and inhibits lipolysis. These processes rely on changes in protein localisation. For example, insulin …
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The effects of linoleate on insulin action in skeletal muscle cells
… mechanism for the negative feedback control of insulin signalling involves the inhibition of tyrosine phosphorylation of IRS-1 by its prior serine/threonine (ser/thr) phosphorylation. IRS-1 ser/thr phosphorylation has been linked to the dissociation of IRS-1 from the insulin receptor and PI3K, …
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Investigation of potential intervention targets to improve insulin action: a therapeutic approach
Impaired insulin action (insulin resistance) is a key factor in the pathogenesis of diabetes mellitus. To investigate therapeutic targets against insulin resistance, this thesis explores the mechanism of action of pharmacological agents and exogenous peptides known or suspected to modify insulin …
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THE ROLE OF CGI-58/ABHD5 IN LIPID METABOLISM, INFLAMMATION, AND INSULIN ACTION
… It is known that inflammation can interfere with insulin signaling and lead to Type 2 diabetes, in which a defective response to insulin causes high blood sugar. The absence of CGI-58 decreased the activation of inflammatory proteins and increased the response to insulin in the liver. We …
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Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
… blood glucose levels are too low: hypoglycemia). Insulin-dependent people with Type 1 diabetes: T1DM) have an impaired ability to sense hypoglycemia and an impaired ability to activate this counterregulatory response: CRR) to hypoglycemia. As a result, T1DM are at a greater risk of experiencing …
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The Influence of Ovarian Sex Steroids on Insulin Receptor Status in Mice
The hypoglycaemic action of exogenously administered insulin was significantly increased in mice at oestrus compared to mice at dioestrus, two stages of the oestrous cycle which represent high and low plasma concentrations of the ovarian sex steroids respectively. Unchanged insulin binding data …
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Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
… of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated H[subscript]2O[subscript]2 emission from muscle mitochondria, and that mitochondrial-targeted scavenging of H[subscript]2O[subscript]2 completely prevents the …
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Investigation of the Effects of Antipsychotics on CNS Insulin-mediated Brain Glucose Uptake using 2DG Autoradiography
… (CNS) suggesting that APs can induce central insulin resistance and disrupt glucose regulation. Attenuated central insulin action has also been shown to be a critical factor in the development of age-related cognitive decline and Alzheimer’s disease (AD). As such, aberrant brain insulin …
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Towards Defence In Depth In Diabetes Glucose Self-Management
… capacity to regulate the blood glucose level. In insulin-dependent diabetes, multiple daily injections of insulin have to be administered. In-between scheduled visits to the care provider, the patient has to manage the glucose control independently. Insulin dosing is a non-trivial task and many …
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The effect of oral-hypoglycaemic drugs and obesity on insulin receptor binding
This thesis is concerned with the regulation of insulin receptors, with respect to receptor number, affinity and certain postreceptor effects of insulin action. The Aston obese hyperglycaemic (ob/ob) mouse was used as an animal model of obesity and type 2, NID diabetes mellitus. Hepatocyte insulin …
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EXAMINATION OF THE CONTRIBUTION OF DIFFERENCES IN DISEASE ARCHITECTURE AND EPISTASIS TO TYPE 2 DIABETES RISK IN AFRICAN AMERICANS
… by high blood sugar resulting from defects in insulin secretion in pancreatic beta cells and defects in insulin action in hepatic, skeletal muscle, and other peripheral tissues. The most recent data shows that the prevalence of diabetes is much higher among African Americans (13.2%) compared to …
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Effects of resveratrol and contractile activity in human skeletal muscle myotubes from severely obese individuals
… of resveratrol treatment (1 [micro]M) improved insulin-stimulated glycogen synthesis, an index of insulin sensitivity in cell culture, as well as glucose oxidation in the myotubes of severely obese individuals despite suppressed responses compared to lean counterparts. The molecular mechanism …
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Verifying the Deletion of Growth Hormone Receptor Using a Quantitative Polymerase Chain Reaction at the mRNA Level in Tissue-Specific GHR-/- Mice
Growth Hormone (GH) inhibits insulin action, and high level GH can result insulin resistance and diabetes in both mice and humans. GH receptor (GHR) gene disrupted mice (GHR-/- mice) have been genetically modified to lack the GHR and GH action. GHR-/- mice are extremely insulin sensitive and have …
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Data mining and mathematical modelling on diabetes
… by significant glucose variation due to lack of insulin secretion, lack of insulin action, or both. DM can be broadly classified into two types: type 1 diabetes mellitus (T1DM) - which is caused mainly due to lack of insulin secretion and type 2 diabetes mellitus (T2DM) - which is caused due to …
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Atualidades no diabetes mellitus.
… of deficiencies in the production mechanism or insulin action in peripheral s tissues, and is mainly connected to the presence of hyperglycemia. Considered a chronic disease of high prevalence, constit utes a public health problem owing to the large increase in incidence in recent decades. This …
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Temporal examination of DNA methylation profile reprogramming in the promoter region of PGC-1α during the progression of insulin resistance and type 2 diabetes mellitus in rodent models
… elevated blood glucose levels and insufficient insulin action, is growing in prevalence worldwide . Barriers to improving disease outcome resolve primarily around identifying and intervening during the preliminary stages of insulin resistance, a state clinically referred to as pre-diabetes. …
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