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Showing 1 to 6 of 6 for “"insertional mutation"”.
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Iron Acquisition in <em>Rhodococcus erythropolis</em> Strain IGTS8: Characterization of a Mutant that Does Not Produce a Siderophore.
… was prepared using DNA flanking the site of insertional mutation in strain N5-59. This probe was then used to clone a 6 kilobase pair, <em>Pst</em>I restriction fragment from the chromosome IGTS8. This cloned DNA is expected to contain the intact gene(s) that was interrupted in N5-59.</p>
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Genetic Analysis of Chondroitin Sulfate Utilization in Bacteroides Thetaiotaomicron (Cloning, Mutagenesis, Polysaccharide)
… for utilization of chondroitin sulfate, an insertional mutation was made within the chondroitin lyase II gene using a portion of the cloned gene in a suicide vector which I had constructed, pE3-1. The resulting strain was unable to produce chondroitin lyase II. However, it still was able to …
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Aggregation & Localization of a Disease-Associated Prion Protein (PrP) Mutant
… encephalopathies: TSEs). A nine-octapeptide insertional mutation in the prion protein: PrP) causes a fatal neurodegenerative disorder in both humans and transgenic mice. To determine the precise cellular localization of this mutant PrP: designated PG14), we have generated transgenic mice …
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Investigating three-dimensional (3D) gelatin methacryloyl (GelMA) hydrogel as a potential scaffold for cell transplantation in Huntington's disease
… vectors are associated with tumorigenesis and insertional mutation, which hinders their potential for clinical translation. Our lab has established a protocol to reprogram human-induced lateral ganglionic eminence precursor cells (hiLGEPs) directly from adult human dermal fibroblasts using …
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Phänotypische und molekulare Analyse einer Maus mit Insertionsmutation und axonaler Reorganisation im Hippocampus
… aberrantes Moosfaser-Wachstum zeigt. Die Mutation dieses Maus-Modells besteht aus einer intronischen Insertion transgener DNA (TC) in das Phospholipase C-beta 1 -Gen der Maus (PLC-ß1TC-/- -Mutation), die zu einer vollständig penetranten Spleiß-Mutation und zu einem kompletten Verlust von …
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Understanding Autism Pathology: Insights from Genetic Mouse Model Manipulation of KCTD13 and SHANK3
… scaffolding protein at excitatory synapses. Mutations and deletions within SHANK3 are known to cause idiopathic autism, Phelan-McDermid (aka 22q13 microdeletion) syndrome, and other neuropsychiatric disorders. We create a novel mouse model of human autism caused by the insertion of a single …