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Showing 1 to 14 of 14 for “"insertion reaction"”.
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Studies on Syntheses of 1-Azaspirocycles, 2,6-Disubstituted 3-Piperidinols and cls-Decahydroquinolines
… The Rh(II)-catalyzed intramolecular tertiary C-H insertion reaction of 5-(-diazoacetoxy)piperidin-2-ones and 3-(-diazoacetoxy)pyrrolidines carrying C6 and C2 alkyl substituents, respectively, was investigated for the formation of bicyclic lactones bearing a nitrogen-substituted quaternary …
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Studies towards the total synthesis of labiatin A
… to the formation of metal carbenoids and the reactions involving metal carbenoids is described. A retrosynthesis of labiatin A involving the use of two metal-carbenoid transformations- intramolecular C-H insertion reaction and oxonium ylide formation followed by [2,3]-sigmatropic …
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Electrochemical behaviour of some organometallic compounds containing iron and molybdenum
… available Tolman's χ-values. The subsequent CO insertion reaction to give an acyl species was found to be dependent on the nucleophilicity of the solvent. The relative rates of decarbonylation of the acyl species could be assessed through cyclic voltammetry. The electrochemical behaviour of …
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Synthesis and cycloaddition chemistry 1,3-Bis(phenylsulfonyl)propadiene
… ether, chloroform, ethyl acetate and benzene. Reaction with methanol occurred to yield (E)-2-methoxy-1 ,3-bis(phenylsulfonyl)prop-I-ene and with tetrahydrofuran to yield 2-(2-tetrahydrofuranyl)-(E)-1 ,3-bis(phenylsulfonyl)propene, in a novel insertion reaction. The homocyclisation of …
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Rhodium(II)-Stabilized Vinylcarbenes: Synthetic Applications in Ylide, Cyclopropanation, and C-H Insertion Reactions
A previously unknown cascade reaction in which two units of a rhodium(II)-stabilized vinylcarbene obtained from methyl trans-styryldiazoacetate react with benzylideneaniline is described; the products of the cascade reaction are complex bicyclic pyrrolidines. An evaluation of reaction conditions …
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NEW TRANSITION METAL CATALYSTS FOR CARBON-CARBON BOND FORMATION
New ligands and the reactions they enable have been the driving force of organometallic chemistry for the past decades. Since their inception, organometallic complexes have been applied to the formation of carbon-carbon bonds both as reagents and catalysts. Ligands and complexes tailored for a …
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Investigation of catalyst effects in enantioselective copper- and rhodium-mediated transformations of α-diazocarbonyl compounds
… enantioselective C–H insertion reactions leading to enantioenriched cyclopentanone derivatives. Through the use of additives, the enantioselectivity achieved with the copper catalysts for the first time reaches synthetically useful levels (up to 91% ee). Chapter one …
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Reaktivität von CO2 gegenüber Si-N-Bindungen
Um die Insertionsreaktionen von CO2 in Si-N-Bidungen genauer zu erforschen wurden 122 Silicium-Verbindungen synthetisiert -- davon 56 erstmalig -- und umfassend strukturell charakterisiert. Wichtige Hinweise auf die Voraussetzungen für das Ablaufen der Insertion konnten aus den qualitativen und …
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Synthesis and reactivity of alpha-trialkylsilyl alpha-amino acids
… protocol involving rhodium(II)-catalysed insertion reactions of alpha-trialkylsilyl alpha-diazo esters into N-H bonds of carbamates. As an extension to this procedure, it was accounted that a diastereoselective approach to N-protected alpha-trialkylsilyl alpha-amino acids precursors may …
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Membrane protein biosynthesis at the endoplasmic reticulum
… model substrate in an in vitro system where the insertion and folding of its TMDs could be interrogated. Assembly of β1-AR is not a straightforward process, and current models of insertion fail to explain how the known translocation machinery correctly identifies, inserts, and assembles β1-AR …
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Efficient & Novel Approaches to Relay Chirality in the Synthesis of Planar Chiral Metallocenes
… in a interesting departure from the Nicholas reaction. Diastereomeric ratios of up to 1:0 in favour of the anti diastereoisomer and yields of up to 67% were observed. Ether and ester linked diynes were synthesised from secondary terminal propargylic alcohols. On heating with (η5– …
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Investigations of catalyst behaviour in the formation of polyurethanes
… as the computational modelling methods. Chemical reaction monitoring, Fourier Transform Infar Red (FTIR) and Nuclear Magnetic Resonance (NMR) spectroscopy analysis were used along with model compound studies for verification of predictions from computational modelling and vice versa. Results show …
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New approaches to antimalarial target deconvolution and measuring fitness effects of Plasmodium falciparum mutations implicated in drug resistance.
… the efficiency of the CRISPR-based barcode insertion reaction, targeting the Pfrh3 locus, that had previously been developed in the lab. When I attempted this approach on a larger scale, it was found that editing was too inefficient with only 5% of transfections being successfully barcoded. …