Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"inositol trisphosphate"”.
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Spatio-Temporal Calcium Dynamics of the Interstitial Cells of Cajal
… between the endoplasmic reticulum (ER), through inositol-trisphosphate receptor (IP3R) release, and mitochondria, through the uniporter. In the intestinal regions, a non-specific cation channel (NSCC) is associated with the membrane depolarizations, and is inhibited by intracellular calcium. One …
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Defining Ankyrin-b Syndrome: Characterization of Ankyrin-b Variants in Mice and Men and the Discovery of a Role for Ankyrin-b in Parasympathetic Control of Insulin Release
… glucose-stimulated insulin secretion by inducing inositol-trisphosphate receptor (InsP3R)-mediated Ca2+ release. We report that ankyrin-B is also enriched in pancreatic beta cells. Ankyrin-B-deficient islets display impaired potentiation of insulin secretion by the muscarinic agonist carbachol, …
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The role of reactive oxygen species in the endothelium derived hyperpolarising factor response
… EDHF mediated relaxation mainly by enhancing the inositol trisphosphate-mediated release of Ca2+ from endothelial stores.
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Identification and Functional Role of Myo-Inositol Polyphosphate 5-Phosphatase Protein Complexes
… through second messenger hydrolysis. Myo-inositol polyphosphate 5-phosphatases (5PTases) (EC 3.1.3.56) have unique signal terminating abilities toward the second messenger inositol trisphosphate (Ins (1,4,5)P3, InsP3). In Arabidopsis thaliana there are 15 members of the 5PTase family, the …
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Ryanodine receptors in calcium signaling pathways
… toxic.</p><p>Ryanodine receptors (RyRs) and inositol trisphosphate receptors (IP<sub>3</sub>Rs) are Ca<sup>2+</sup> -release channels located on intracellular membranes of the endoplasmic reticulum (ER)/sarcoplasmic reticulum (SR) that perform essential functions as key targets of …
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The Role of Calcium in Signal Transduction: Kinetics and Regulation of Intracellular Calcium During the Photomechanical Response of the Albino Rat Sphincter Pupillae Smooth Muscle
… → G-protein → phospholipase C → inositol trisphosphate → intracellular calcium → calcium-calmodulin complexes → myosin light chain kinase → phosphorylated myosin → force. In the isolated vertebrate sphincter pupillae, the myosin phosphorylation cascade can …
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Innate and humoral immune responses to HIV-1
… a novel autoepitope shared by three ER-resident inositol trisphosphate receptors, validated through binding studies and immunohistochemistry. Tissue staining with 4E10 demonstrated reactivity consistent with the type 1 inositol trisphosphate receptor as the most likely candidate autoantigen. …
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Molecular Characterization of Two myo-Inositol Oxygenases in Arabidopsis thaliana
… One stress-responsive system involves myo-inositol (Ins). Ins is a precursor for cell wall components, inositol trisphosphate (Ins(1,4,5)P3) and phosphatidylinositol phosphate signaling molecules, and an alternate ascorbic acid (AsA) synthesis pathway. The enzyme, myo-inositol oxygenase …
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Dual Regulation of Phospholipase C-beta by G betagamma
… isoforms to catalyze hydrolysis of phosphatidylinositol-1,2-bisphosphate (PIP2) generating the second messengers, inositol trisphosphate (IP3) and diacylglycerol (DAG). PLC-b isoforms are also GTPase activating proteins (GAPs) for Gaq, and Gbg subunits inhibit the GAP activity of PLC-b. …
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Calcium Dyshomeostasis In Neurodegeneration
… Cβ (PLCβ) activity, which led to greater inositol trisphosphate receptor (IP<sub>3</sub>R)-mediated Ca<sup>2+</sup> release. Depolarization-induced augmentation of PLCβ-IP<sub>3</sub>R signaling increased mitochondrial [Ca<sup>2+</sup>] and ATP production, suggesting that activity of this …
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An Investigation into the Function of CDS2 in Phosphoinositide Synthesis in Murine Macrophages
… PLC generates the second messengers inositol (1,4,5)-trisphosphate and diacylglycerol (DAG) from phosphatidylinositol (4,5)-bisphosphate, resulting in a net loss in the cellular PIPn pool which is replenished by the activation of phosphatidylinositol (PI) synthesis. A critical …
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Signaling Induced by Inflammatory Mediators in the Rodent Pulmonary Microvasculature
… propagating the thrombin-induced increase was inositol trisphosphate (IP3). We also found that, though thrombin induced increases in mean Ca2+in cultured cells, it instead induced increases in the amplitude of cytosolic Ca2+ oscillations in pulmonary microvessels. While we observed that …
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Identification of a Dual-Action Small Molecule with Potent Anti-diabetic and Anti-obesity Activity
… in intracellular [Ca2+]i and the production of inositol trisphosphate in L-cells, indicating that EA activates phospholipase C (PLC)-mediated signaling. Consistently, inhibition of (PLC) ablated EA-stimulated increase of [Ca2+]i and GLP-1 secretion in L-cells. In addition, EA-triggered GLP-1 …
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REGULATION AND PHYSIOLOGICAL ROLE OF NON-CLATHRIN ENDOCYTOSIS OF THE EPIDERMAL GROWTH FACTOR RECEPTOR
… NCE sites occurs through the activation of the inositol trisphosphate receptor (IP3R) on the ER membrane and is required for the fission of EGFR/CD147-positive NCE vesicles from the PM. At the functional level, we extended the relevance of NCE to alternative EGFR ligands, beyond the EGF. …
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A MULTIORGANELLE PLATFORM REGULATES EGFR ENDOCYTOSIS AND SIGNALLING
… released from the ER at these sites through the inositol trisphosphate receptor (IP3R), is required, along with the dynamin, for the fission of TIs and the completion of EGFR-NCE. Preliminary data from our laboratory suggested the possible involvement of mitochondria in EGFR-NCE: a significant …
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Cytotoxic T lymphocyte biology under the microscope
… of killing are at play. ITPR3 encodes the inositol trisphosphate receptor, which allows for calcium release from the endoplasmic reticulum in response to TCR activation. I characterise how point mutations in this receptor, present in patients with immunodeficiency, lead to lack of calcium …