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Showing 1 to 6 of 6 for “"inositol 1,4,5-trisphosphate receptor"”.

  1. Cloning and expression studies of the human type I Inositol 1,4,5-Trisphosphate receptor

    Niu, Ting-KuangThe University of Edinburgh2000

    edinburgh Repository record

  2. Camkii-Mediated Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor at Serine-150 Results in Decreased Channel Activity

    Maxwell, Joshua Thomas2016

    … intracellular stores is via the activation of inositol 1,4,5-trisphosphate receptors (InsP3Rs) by the second messenger, inositol 1,4,5-trisphosphate (InsP3). InsP3 is produced when certain factors bind to G protein-coupled receptors on the plasma membrane, causing activation of phospholipase C …

    loyola-thes Repository record

  3. The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis

    Hedgepeth, Serena ClarkThe University of Texas Medical Branch at Galveston2016

    The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitously expressed endoplasmic-reticulum (ER)-resident calcium channel. Calcium release mediated by IP3Rs influence many signaling pathways including those regulating apoptosis. IP3R activity is regulated by protein-protein interactions, …

    utmb Repository record

  4. Control of Cardiac Hypertrophic Signaling by Inositol 1,4,5-Trisphosphate Receptors

    Garcia, Martha IThe University of Texas Medical Branch at Galveston2018

    … metabolism, gene expression, and cell death. The inositol 1,4,5-trisphosphate receptor (IP3R) is a calcium channel expressed in cardiac tissue. There are three IP3R isoforms encoded by separate genes. In the heart, the IP3R-2 isoform is reported to being most predominant with regards to expression …

    utmb Repository record

  5. Examinations into the Calcium Hypothesis of Alzheimer's Disease

    Shilling, Dustin J2013

    … [Ca2+]i signaling is dependent upon the inositol 1,4,5-trisphosphate receptor (InsP3R) and contributes to AD pathogenesis in vivo. We began our studies by testing multiple proposed mechanisms for exaggerated [Ca2+]i signaling. To do this we employed multiple Ca2+ imaging protocols and …

    penn Repository record

  6. Mitochondria-Endoplasmic Reticulum Contact Sites: Regulation and Roles in Coordinating Cell Fate Decisions

    Morris, Jordan LukeUniversity of Cambridge2021

    … epigenetic silencing of ITPR3, which encodes the inositol-1,4,5-trisphosphate receptor-3 (IP3R3). Using live cell spinning disk confocal microscopy, the loss of IP3R3 was demonstrated to impair ER to mitochondria Ca2+ transfer in these cancers, which subsequently inhibits apoptosis. This is …

    cambridge Repository record