Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 30 for “"inositol (1,4,5)-trisphosphate"”.
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Dual regulation of inositol 1,4,5-trisphosphate receptors by inositol 1,4,5-trisphosphate and phosphatidylinositol 4,5-bisphosphate
… of a vast array of cellular processes. Inositol 1,4,5-trisphosphate receptors (IP<sub>3</sub>Rs) are key signal integrators, which transform extracellular stimuli into intracellular Ca<sup>2+</sup> signals. Only immobilised IP<sub>3</sub>Rs, licensed by association with KRas-induced …
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Control of Cardiac Hypertrophic Signaling by Inositol 1,4,5-Trisphosphate Receptors
… metabolism, gene expression, and cell death. The inositol 1,4,5-trisphosphate receptor (IP3R) is a calcium channel expressed in cardiac tissue. There are three IP3R isoforms encoded by separate genes. In the heart, the IP3R-2 isoform is reported to being most predominant with regards to expression …
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High-resolution optical analyses of inositol 1,4,5-trisphosphate receptors and the Ca²⁺ puffs they evoke
… Many intracellular Ca²⁺ signals are initiated by inositol 1,4,5-trisphosphate receptors (IP₃Rs) which respond to IP₃ produced when cell-surface receptors stimulate phospholipase C. IP₃Rs are regulated by both IP₃ and Ca²⁺, a property which allows Ca²⁺-induced Ca²⁺ release (CICR) between …
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Ratio-PCR to determine relative levels of expression of inositol 1,4,5-Trisphosphate receptors in rat tissues
This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department (rlmlill@iu.edu).
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Camkii-Mediated Phosphorylation of the Inositol 1,4,5-Trisphosphate Receptor at Serine-150 Results in Decreased Channel Activity
… intracellular stores is via the activation of inositol 1,4,5-trisphosphate receptors (InsP3Rs) by the second messenger, inositol 1,4,5-trisphosphate (InsP3). InsP3 is produced when certain factors bind to G protein-coupled receptors on the plasma membrane, causing activation of phospholipase C …
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The Tumor Suppressor BRCA1 in IP3R Calcium Signaling and Apoptosis
The inositol 1,4,5-trisphosphate receptor (IP3R) is a ubiquitously expressed endoplasmic-reticulum (ER)-resident calcium channel. Calcium release mediated by IP3Rs influence many signaling pathways including those regulating apoptosis. IP3R activity is regulated by protein-protein interactions, …
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Molecular Characterization of Inositol Monophosphatase Like Enzymes in Arabidopsis thaliana
myo-Inositol synthesis and catabolism are crucial in many multicellular eukaryotes for production of phosphatidylinositol and inositol phosphate signaling molecules. myo-inositol monophosphatase (IMP) is a major enzyme required for the synthesis of myo-inositol and breakdown of inositol …
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The Role of Arabidopsis thaliana P80 in Inositol Signaling
The myo-inositol signaling pathway in plants allows them to sense external environmental stimuli and respond to them. This signaling pathway depends on the dynamic levels of the second messenger, inositol(1,4,5)trisphosphate, which in turn is regulated by inositol polyphosphate 5-phosphatases …
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Microvascular endothelial response to cocaethylene exposure: morphological and molecular observations
… and total cellular free calcium ion (Aim Three), inositol 1,4,5 trisphosphate, and phosphorylated p38 mitogen-activated protein kinase concentrations, as well as changes in DNA binding activity and dimer composition of nuclear factor-kappaB (Aim Four). The observed changes suggest a distinct …
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Social isolation enhances calcium signaling and synaptic plasticity in dopamine neurons of the ventral tegmental area
… calcium (Ca²⁺) signaling via an increase in inositol 1,4,5-trisphosphate(IP3) sensitivity. Isolation-mediated effects on Ca²⁺ signaling and NMDAR plasticity were not reversed by a subsequent period of resocialization. Furthermore, social isolation during this critical period occludes the …
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Examinations into the Calcium Hypothesis of Alzheimer's Disease
… [Ca2+]i signaling is dependent upon the inositol 1,4,5-trisphosphate receptor (InsP3R) and contributes to AD pathogenesis in vivo. We began our studies by testing multiple proposed mechanisms for exaggerated [Ca2+]i signaling. To do this we employed multiple Ca2+ imaging protocols and …
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The Role of Protein S-glutathionylation on Ca2+ Signaling in Cultured Aortic Endothelial Cells
… Ca2+. Oscillations in [Ca2+]i were due to inositol 1,4,5-trisphosphate (IP3) receptor (IP3R) activation, since they were attenuated by pharmacological inhibition of either phospholipase C or IP3Rs themselves. However, diamide, even at high concentrations, did not increase PIP2 hydrolysis, …
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Identification and characterization of the acid phosphatase from Francisella tularensis and its potential role in pathogenesis
… dephosphorylation of phosphatidylinositol 4,5-bisphosphate and inositol 1,4,5-trisphosphate is believed to play an important role in the intracellular survival of these pathogens. Results from this study show that the intracellular pathogen, F. tularensis (Ft) produces a …
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A Physiological, Biochemical and Structural Analysis of Inositol Polyphosphate 5-Phosphatases from Arabidopsis thaliana and Humans
The complete role of inositol signaling in plants and humans is still elusive. The plant Arabidopsis thaliana contains fifteen predicted inositol polyphosphate 5- phosphatases (5PTases, E.C. 3.1.3.36) that have the potential to remove a 5-phosphate from various inositol second messenger substrates. …
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Molecular Characterization and Loss-of-Function Analysis of an Arabidopsis thaliana Gene Encoding a Phospholipid-Specific Inositol Polyphosphate 5-Phosphatase
The phosphatidylinositol signaling pathway utilizes inositol-containing second messengers to mediate signaling events. The enzymes that metabolize phosphoinositides can in some cases serve to terminate the signaling actions of phosphoinositides. The inositol polyphosphate 5-phosphatases (5PTases) …
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The Role of Calcium Signalling in Autophagy
… that prevented Ca<sup>2+</sup> release from inositol 1,4,5-trisphosphate receptors, inhibition of mitochondrial respiration, and knockdown of the mitochondrial Ca<sup>2+</sup> uniporter. The triggering of autophagy under these conditions was due to reduced cellular ATP levels. These data …
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Mechanisms of Calcium Wave Initiation and Propagation in Astrocytes
… and the mobilization of Ca<sup>2+</sup> from inositol-1,4,5-trisphosphate (IP3) dependent stores. This lead to the hypothesis that Ca waves are mediated by mobilization of IP3 in the stimulated cell that then diffuses to surrounding cells through gap junctions composed of Cx43 where it …
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Interactions between IP3 receptor and Kras-induced actin-interacting protein
Inositol 1,4,5-trisphosphate receptors (IP3R) function as intracellular channels, facilitating the release of Ca2+ from the endoplasmic reticulum (ER) upon IP3 binding. Before responding to IP3 in intact cells, IP3R must undergo a process called 'licensing,' involving the association with …
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