Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 121 for “"inner ear"”.
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Olfactory progenitor cell transplantation into the mammalian inner ear
… of cellular therapy technology for the inner ear is the development of an in vitro model for assessing the optimal conditions for successful application of cells. The first part of this thesis describes the adaptation of the cochleovestibular structure harvested from P1 mouse pups for …
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Rarity of Novel microRNAs in the Mouse Inner Ear
The vertebrate inner ear is a complex organ that is highly regulated throughout development by molecular and cellular factors such as morphogens and transcription factors. Another class of gene regulators whose function in the inner ear is essential but not well understood is microRNAs. Previous …
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The Role of Pkd1 in Mouse Inner Ear Hair Cells
… mechanoelectrical transduction (MET) channel in inner ear hair cells based on PC-1 role of fluid flow sensing and calcium uptake into renal epithelial cells. However, two independent mouse lines with PC-1 mutations exhibit normal MET channel function despite hearing loss and ultra-structural …
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Evidence of inner-ear mechanisms in bone conduction in chinchillas
… of how airborne sound is conducted to the inner-ear via the outer ear and middle ear, so-called air conduction (AC), the mechanisms by which vibrations of the head and body, so-called bone conduction (BC), produce an auditory response are not well understood. It is clear that the inner ear …
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Small-Molecule Activation of Yap for Inner-Ear Regeneration – and Beyond
… proliferation of murine supporting cells in the inner ear, murine cardiomyocytes, and human Müller glia in retinal organoids. The compound promotes the initial stages of the proliferative regeneration of hair cells, a process thought to be permanently suppressed in the adult mammalian inner ear. …
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Daple Orients and Patterns Sensory Hair Bundles in the Inner Ear
… the integration of diverse pathways. In the inner ear, at least two systems regulate the planar polarity of the hair bundle. The core planar cell polarity (PCP) proteins coordinate the orientations of hair cells across the epithelial plane. The cell-intrinsic patterning of each hair bundle is …
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Inner ear morphology in elasmobranchs: implications for auditory capacity and ecology
… a clade of cartilaginous fishes that first appeared over 400 million years ago. Given their basal position in the evolutionary tree of gnathostomes, elasmobranchs can provide key insights into the early evolutionary history of the vertebrate nervous system. Sharks and their relatives were some …
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Studies relating to middle and inner ear disease in the albino rat.
Abstract not available.
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Neural and mechanical responses to electric stimulation of the cat's inner ear.
Massachusetts Institute of Technology. Dept. of Electrical Engineering. Thesis. 1971. Ph.D.
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Cochlear morphology and sound-induced motion of the apical mammalian inner ear
… and dynamic range are hallmarks of mammalian hearing. While a variety of cellular and molecular mechanisms are known to be critical to these properties, how the cellular and molecular mechanisms interact to generate the remarkable properties remains unclear. Direct observations of these …
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Development of the Inner Ear: a Molecular, Cellular and Evolutionary Approach to Understanding the Development of the Inner Ear with an Emphasis on the Roles of Fgf10 and Foxgl
(First paragraph) Hearing loss is a condition affecting people of all ages and can be categorized as either conductive or sensorineural. Conductive hearing loss is caused by pathology of the middle ear and will not be addressed in this volume. Our focus here is on sensorineural hearing loss, or …
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Genomic Approaches for Pathway Identification in Regenerating Sensory Epithelia of the Inner Ear
The inner ear utilizes sensory hair cells as mechano-electric transducers for sensing sound and balance. In mammals, these sensory hair cells lack the capacity for regeneration and if damaged lead to hearing or balance disorders. However, non-mammalian vertebrates such as birds maintain their …
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Playing the Ear: Non-Linearities of the Inner Ear and their Creative Potential
… psychoacoustic phenomena relating to the non-linear nature of the inner ear as an electroacoustic compositional tool. The compositions included in this portfolio explore the validity of a variety of non-linear inner ear phenomena within composition by employing them as primary compositional …
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Molecular Interactions of Basic Helix Loop Helix (bHLH) Genes in Inner Ear Development
The inner ear originates from an ectodermal thickening, the otic placode, which invaginates and forms the otic vesicle. The otic placode gives rise to the hearing (cochlea) and balance (vestibular) organs, comprising the sensory hair cells and sensory neurons of the cochlear (spiral) and vestibular …
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Investigation of current flow in the inner ear during electrical stimulation of intracochlear electrodes
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1987.
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A hair bundle proteomics approach to discovering actin regulatory proteins in inner ear stereocilia
… development, maintenance, and function in the hearing system, I decided to pursue a proteomics-based approach to discover proteins that play a role in stereocilia function. I employed a modified "twist-off" technique to isolate hair bundle proteins, and I developed a method to purify proteins …
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Finite-element analysis of inner ear hair bundles: a parameter study of bundle mechanics
Inner ear hair cells have been identified as the sites of mechanoelectrical transduction from a mechanical event (e.g. hearing, motion) to an electrical event (e.g. neural response). Deflection of bundles of hair-like stereocilia extending from these cells has been associated with the transduction …
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Next Generation Sequencing Reveals Gene Expression Patterns in the Zebrafish Inner Ear Following Growth Hormone Injection
… due to acoustic trauma results in the loss of hearing. In humans, unlike other vertebrates, the mechanism of hair cell regeneration is not possible. The molecular mechanisms that underlie this regeneration in nonmammalian vertebrates remain elusive. To understand the gene regulation during hair …
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Generation of human inner ear organoids from pluripotent stem cells and an organ-on-chip platform
Inner ear development involves the assembly of cells from a variety of different embryological origins. There is an unmet need for developing a human inner ear model in vitro to mimic both the complex structure and the function of the inner ear outside of the body. Since the human inner ear is …
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