Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"innate lymphoid cells"”.
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Group 2 innate lymphoid cells and reproduction
… Recent findings showed that tissue-resident innate lymphoid cells (ILCs) are crucial regulators of both physiology and pathology of the tissues they populate. Uterine natural killer (uNK) cells are a subtype of ILCs known to regulate trophoblast invasion, uterine vascular adaptation to …
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Molecular definition of group 1 innate lymphoid cells in the uterus
Uterine NK cells (uNKs) are group 1 (g1) innate lymphoid cells (ILCs) that have been shown to regulate remodelling of uterine blood vessels, an event necessary to support fetal growth. Recently, other ILCs were identified in the mucosa and wall of the uterus of mice and women, pregnant or not. They …
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Identification and characterisation of Group 3 Innate Lymphoid Cells in the renal tract
Innate lymphoid cells (ILCs) bear similarities to T-helper (Th) cells, but lack T cell receptors. The three groups mirror the effector functions of Th1, Th2 and Th17 cells and share the same transcription factors and cytokine profiles. This project focussed on type 3 ILCs (ILC3s) found primarily at …
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Investigating the role of innate lymphoid cells in targeted radiotherapy in lung cancer
… in lung cancer. In the lung, ILC2s are critical innate lymphocytes that modulate Type 2 immunopathology, but their role in modulating the immune response to lung cancer is not fully understood. Furthermore, it is unclear how ILC2s respond to targeted lung radiotherapy. In this thesis, I …
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The role of type 2 innate lymphoid cells in the pathogenesis of pancreatitis
Type 2 Innate Lymphoid Cells (ILC2s) are recently discovered tissue resident immune cells, studied more commonly in barrier tissues like the lung and intestine. ILC2s are critical mediators of early type-2 immune responses and play a crucial role in the clearance of parasites, but also in the …
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Characterising the crosstalk between pancreatic fibroblasts and group 2 innate lymphoid cells in pancreatic homeostasis, inflammation, and neoplasia
Group 2 innate lymphoid cells (ILC2) are important orchestrators of type 2 inflammation with established roles in anti-helminth immunity and allergic disease. More recent studies have shown both pro- and anti-tumourigenic functions, indicating our incomplete understanding of their role in cancer. …
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Innate Lymphoid Cell Characterization and Ilc2S In Neuroinflammation In Aging and Sex Differences
… females prefer Th2 responses. As tissue-resident innate lymphoid cells (ILC) are novel immune cells that are the innate complement to T cells, understanding their role in aging and sex differences is imperative.</p> <p>Here, ILCs are characterized within various C57Bl6/J mice tissues and defined …
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Regulation of Adaptive and Innate Immunity by the Circadian Transcription Factor NFIL3
… factor NFIL3 is critical for both adaptive and innate immunity by regulating TH17 cells and innate lymphoid cells (ILCs), respectively. First, NFIL3 transcriptionally represses RORgt, the master regulator of TH17 cells, by directly binding to the Rorgt promoter and thereby suppresses TH17 cell …
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THE ROLE OF GUT METABOLITES ON REGULATION OF INTESTINAL IMMUNITY
… tract contains multiple types of immune cells that induce various immune responses to dietary antigens, commensal bacteria, and pathogens. Maintaining homeostasis at this mucosal barrier requires stringent regulation of the immune responses, including mechanisms to convey information …
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The role of Surfacant Protein D in the control of human helminth infections
… is essential for both homeostasis and as an innate immune opsonin. In the project presented here, we aimed to translate data recently published by our group, which demonstrated that SP-D contributes to protection against murine parasitic nematode infections, to human work. In the first part …
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Investigating the immune response to central nervous system invasion by Brucella
… and uncover the pivotal role that innate lymphoid cells play in the prevention of disease. By utilizing various immunohistochemical stains, we became the first researchers to successfully visualize Brucella in the brains of experimentally-infected mice and suggested a potential …
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Exploiting Ruminococcus gnavus and Limosilactobacillus reuteri to strengthen host immunity and treat infections
… gnavus and L. reuteri require Myd88 and group 3 innate lymphoid cells (ILC3s) for induction of Reg3. Interestingly, R. gnavus and L. reuteri suppress Reg3 in the absence of either Myd88 or ILC3s. Additionally, we demonstrated that colonization by these bacteria is not required for induction of …
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Innate memory to bacterial infection
The innate lymphoid cells (ILCs) ILC1, ILC2, and ILC3, which also includes the natural killer (NK) cells are important regulators and first line responder during pathogen invasion. The role of ILCs was evaluated using FACS sorting, cytokine production and surface markers analysis, cell depletion, …
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The Impact of IL-9 on Disease in Murine Models of Systemic Lupus Erythematosus
… has been shown to have elevated CD4+IL-9+ T cells as well as increased secreted IL-9 and Il9 mRNA compared to healthy controls. In other antibody mediated autoimmune models, such as rheumatoid arthritis, type II innate lymphoid cells (ILC2s) secrete increased IL-9 to promote the suppressive …
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Identify the regulatory roles of intestinal secretory cell lineages during gut inflammation
… the roles of secretory intestinal epithelial cells, specifically tuft cells and enteroendocrine cells (EECs), in colonic inflammation, revealing novel cellular and molecular dynamics. The initial study utilized IEC-specific Hnrnp I knockout mice to demonstrate significant upregulation of …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
Interleukin-25 (IL-25) and group 2 innate lymphoid cells (ILC2s) play critical roles in the host immune defense against intestinal parasitic helminth infections, through orchestrating the protective type 2 immune response, eliciting pathogen clearance, and promoting tissue repair. However, IL-25 …
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From Flare to Repair: Commensal Bacteria's Influence on Inflammation and Wound Healing
… 4 we demonstrate that gut commensal CD4+ T cells specific for an ileum-colonizing microbe, segmented filamentous bacteria (SFB), drive neuroinflammation in the absence of regulatory T cell control. These T cells become dysregulated in the gut, gain a license to cross the blood brain barrier, …
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Neutrophil-Derived IFN-γ in Toxoplasma gondii Infection and Innate Immunity
… Production of IFN-γ by Natural Killer (NK) and T cells is initiated by the recognition of pathogens through Toll-like receptors (TLRs). In an experimental model of toxoplasmosis we have identified the presence of a non-lymphoid source of IFN-γ that was particularly evident in the absence of …
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Innate Interleukin-17 and Interleukin-22 play important roles in viral hepatitis
… expansion of IL-17- and IL-22-producing cells in mouse liver during viral infection. We found that a subset of IL-17+ and IL-22+ cells expressed no myeloid/lymphoid lineage markers. Instead, they expressed high levels of stem-like markers, IL-7Rα and RORγt, consistent with the newly …
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Defining the role of the transcription factor T-bet in the innate immune system in intestinal inflammation.
… lacking the transcription factor T-bet in the innate immune system (Tbx21-/- x Rag2-/- Ulcerative Colitis, or TRUC) develop microbiota-dependent inflammatory bowel disease (IBD). The innate immune mechanisms responsible for causing disease are still to be resolved, yet potentially offer novel …
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