Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"innate immune signalling"”.
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Visualisation of innate immune signalling complexes in cells by cryo-electron tomography
Innate immune signalling is a vital immune response to various infections and cell damage. A common feature of innate signalling complexes is forming a signalling platform through oligomerisation in cells. RIG-I-like receptors (RLRs), RIG-I, MDA5 and LGP2 sense cytosolic viral dsRNA and then …
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Investigating the regulation and enzymatic function of human ecsit in innate immune signalling.
Toll-like receptor (TLR) signalling represents the first line of defence against infection. TLRs respond to recognition of pathogens by activating transcription factors such as NFκB and the interferon regulatory factors (IRF)s to induce pro-inflammatory cytokines and IFNs. Whilst many of the …
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Exploring new regulators of innate immune signalling pathways with a particular focus on inflammasomes
Inflammasomes are innate immune signalling complexes vital in the activation of caspase-1, inflammation and wound healing. The dysregulation of inflammasome activity has been linked to the development of autoinflammatory diseases. Recently, the role of post-translational modifications has been …
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Probing the Mechanisms Underlying the Regulatory Effects of Cactin in Innate Immune Signalling Pathways
… Pattern Recognition Receptors (PRR)s used by the innate immune system to recognise conserved microbial motifs which are characteristic of invading pathogens. Activation of TLRs initiates signalling cascades resulting in the activation of transcription factors such as NF-κB and members of the …
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Investigating new roles of the ubiquitin proteasome system in cell death and innate immune signalling
Immune responses are a complex network of interactions between proteins in different cellular processes with multiple layers of regulation. In the present study, we explored the role of some regulators of the ubiquitination and proteasome systems in cell death and innate immune signalling pathways …
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Identifying potential genetic, phenotypic and epigenetic predictive markers in the Toll-like receptor/Interleukin-1 domain innate immune signalling pathway for severe gastrointestinal toxicity risk following 5-Fluorouracil-based therapy
… Toll-like Receptor/Interleukin-1 (TIR) domain innate immune signalling pathway to be predictive for severe GI toxicity risk. The TIR domain pathway is one of the key mediating pathways in the development of GI toxicity and consists of membrane bound Toll-like Receptors (TLRs), adapter proteins, …
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Functional Characterisation of a Novel Tir-Domain containing Protein in Immune Signalling
Dysregulation of innate immune signalling pathways has been implicated in a host of chronic inflammatory disorders including Multiple Sclerosis, Crohn’s Disease and Rheumatoid Arthritis. As a result, it is critical that there are tight regulatory mechanisms in place to rigidly control such …
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The role of human DEAD-box protein DDX3X in the activation and function of Estrogen Receptor-alpha
… RNA helicase DDX3X was shown to be involved in innate immune signalling pathways mediated by IKKε and TBK1. Interestingly, both DDX3 and IKKɛ have independently been shown to act as breast cancer oncogenes. In breast cancer, DDX3 expression was shown to be upregulated and linked with …
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The role of the DEAD box Helicase DDX3X in Anti-‐Viral Signalling Pathways Mediated by the Kinase IKKα.
… has previously been shown to be involved in innate immune signalling in pathways mediated by IKKε and TBK1. In this work we show that DDX3X is also involved in pathways independent of these kinases, and functions by interacting with two related kinases IKKα and NIK. DDX3X enhances the …
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Investigating the mechanisms behind the immunostimulatory activity of influenza A virus RNA polymerase mutations
Activation of innate immune signalling during influenza A virus (IAV) infection is essential for the development of protective antiviral responses. However, uncontrolled release of proinflammatory cytokines is also associated with severe and fatal disease caused by highly pathogenic avian and …
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Inflammasomes in the Intestinal Epithelium
Inflammasomes are multiprotein signalling complexes that detect a diverse range of pathological stimuli to activate inflammatory caspases, resulting in cell death and the release of IL-18 and IL-1. Inflammasomes are important in a wide range of diseases, in particular with auto-inflammatory …
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Investigating the functional roles of the viral frameshift protein 2B* in EMCV infection
… ability of EMCV proteins to antagonise the host innate immune system, reducing the antiviral response. In 2011 the genome of EMCV was found to encode a thirteenth viral protein, 2B*, in an overlapping open reading frame within the gene for 2B. 2B* is translated via programmed ribosomal …
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Analysis of the role of Pellino2 in the Activation of the NLRP3 Inflammasome.
The innate immune system is the first line of defence against invading pathogens and is responsible for both initial pathogen recognition and mounting an effective immunological response. The recognition of conserved pathogen-associated molecular patterns can be carried out by a number of families …
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An investigation into the role of Pellino2 in lung inflammation
… that have been implicated in regulation of innate immune signalling pathways including that employed by IL-1. IL-1 signalling is an important component in the development of emphysema and COPD, for which there is no known cure. In an effort to understand the mechanisms leading to the …
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Investigating the cellular localisation of DEAD box helicase DDX3
… DDX3 has also been shown to play a role in innate immune signalling and tumorigenesis. DDX3 is targeted by multiple viruses: HIV, HCV , HBV and Vaccinia Virus have all been shown to interact with DDX3; either using DDX3 to replicate or inhibiting DDX3’s function in antiviral signalling. …
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Investigating the role of MyD88 signalling pathway in immune mediated diseases
… response protein (MyD88) plays a central role in innate immune signalling by acting as an adaptor protein downstream of most of the Toll-like receptor (TLR) family and all the IL-1 receptor family members. Activation of MyD88 dependent signalling is critical for the immune response during …
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Investigation of the potential of Spleen Tyrosine Kinase (SYK) as a target for host-directed therapy during mycobacterial infection in macrophages
… tyrosine kinase (SYK) plays an important role in innate immune signalling. It is expressed on innate immune cells such as macrophages. Macrophages play a critical role in thepathophysiology of TB. They are the first responders to Mtb infection and are phagocytic cells that engulf and destroy Mtb. …
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Decoding aberrant RNA Synthesis by the Influenza A Virus
… RNAs (diRNAs) and mini viral RNAs (mvRNAs). The innate immune system serves as the body's primary defence against viruses. Within this intricate defence network, RIG-I is responsible for detecting viral RNAs in the host cell, initiating a signalling cascade that ultimately triggers the expression …
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Characterisation and therapeutic modulation of toll-like receptor signalling in response to the intracellular pathogen F. tularensis
The induction of an innate immune response upon infection is dependent on the detection of the invading organism and the generation of a signalling cascade leading to the production of inflammatory mediators. Toll-like receptors are expressed on multiple cell types and induce the activation of a …
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Vaccinia virus BTB-Kelch proteins
… also investigated. The effect of VACV BBKs on innate immune signalling was studied, and NF-κB was selected as a starting point because the ectromelia virus (ECTV) orthologue of A55, ECTV EVM150, inhibits NF-κB signalling. Consistent with this, A55, C2 and F3 all inhibit NF-κB signalling pathway …
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