Global ETD Search
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Showing 1 to 20 of 237 for “"innate immune response"”.
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Haemophilus influenzae adhesins and the innate immune response
… influenzae adhesins and their interactions with innate defense mechanisms. Vitronectin is a glycoprotein that regulates the terminal pathway of the complement system by inhibiting the membrane attack complex. We demonstrate that Haemophilus influenzae surface fibrils (Hsf) may increase the …
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Disruption of Dna Polymerase Zeta Promotes An Innate Immune Response
… that loss of pol ζ promotes activation of an innate immune response.</p> <p><em>Rev3l </em>knockout MEFs had over 1000 genes that were either upregulated or downregulated more than 4-fold. Importantly, this revealed that loss of <em>Rev3l</em>induced an increase in expression of known …
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An innate immune response to DNA damage in prostate cancer
… in solid tumors characterised by STING mediated immune signalling due to abnormal DNA as a result of loss of DNA repair mechanisms. This subtype is characterised by activation of cytokines, such as CXCL10, which attract lymphocytic infiltration and up regulate immune checkpointing genes like …
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Neuronal Regulation of the Innate Immune Response in Caenorhabditis elegans
<p>The innate immune system is the front line of host defense against microbial infections, but its rapid and uncontrolled activation elicits microbicidal mechanisms that have deleterious effects. Increasing evidence indicates that the metazoan nervous system, which responds to stimuli originating …
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Understanding the Effect of BVDV on Innate Immune Response of Neutrophils
… targeting antigen presenting cells, adaptive immune system cells and cytokine gene expression. However, very little research has been done to determine the effect of BVDV on neutrophils. Neutrophils are one of the most abundant while blood cells (WBC) in the peripheral blood, which play a …
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The cell-intrinsic innate immune response to DNA damage in human cells
The innate immune response has evolved to detect DNA from viruses and intracellular bacteria and differentiate this from our almost identical self-DNA. DNA detected in the cytoplasm is thought to be identified as foreign due to its location, and bacterial DNA in endosomes in recognised by its …
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The role of BRD4 in the innate immune response to gastrointestinal infection
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Dynamics of the innate immune response to infection: a mathematical modelling approach
The innate immune system plays a vital role in the control of infection, but many aspects of its behaviour are not fully understood. In this dissertation, I use mathematical modelling approaches to elucidate two linked processes which are key to the innate immune response to Salmonella infection. …
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The innate immune response to HSV-1: glycoprotein mediated activation of dendritic cells
… of DC and the consequent initiation of an immune response. Defining this role has important implications not only in understanding immunopathogenesis, but also in the study of HSV-1 as an immunotherapeutic vector, and in the design of an efficient HSV-1 vaccine. Monocyte-derived DCs (MDDC) …
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Effect of Advanced Age on the Innate Immune Response to Cutaneous Wound Infection
… immunologic function that contributes to a poor response to vaccination, infection and tissue injury resulting in prolonged hospital stays and age-related morbidity and mortality. Specifically, clinical observations and laboratory studies have suggested an age-related decline in cutaneous wound …
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The Role of Serum Ficolins in the Innate Immune Response to Aspergillus species.
… molecules, termed ficolins, could contribute to innate resistance against A. fumigatus and whether they could be used as novel biomarkers for fungal infection. Serum ficolins from both humans (L- and H-ficolin) and rodents (ficolin-A) bound to A. fumigatus in a concentration-, calcium- and …
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Host-pathogen interactions in the innate immune response of the nematode Caenorhabditis elegans
… is mediated by the reciprocal activity of two immune genes: the lysozyme lys-7 and the tyrosine kinase abl-1. We suggest that ABL-1 controls two different DAF-16-dependent pathways to regulate this balance. Both pathways are necessary for wild type resistance to C. neoformans, whilst the …
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Epigenetic regulation of gene expression by BRD4 in cancer and innate immune response
… the E2F/miR-106b-5p/p21 axis. Meanwhile, in the innate immune response, Brd4 engages Irf8 and Pu.1 in maintaining the transcription of Naips and Nlrc4, which confers a prompt inflammasome activation against invading pathogens. Of note, mechanistically, BRD4’s transcriptional activities highly, …
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Role of the Innate Immune Response to DNA During Therapy with Oncolytic Viruses
… as immunotherapies is to stimulate the host's immune system culminating in a systemic anti-tumour response. To do so relies on OVs ability to trigger to two distinct forms of immunity simultaneously: anti-tumour and anti-viral. OV-induced anti-viral immunity typically refers to release of …
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Unraveling the host innate immune response to a respiratory model of Brucella abortus
… information is available on how they stimulate innate immunity. This knowledge is critical for improving these vaccines for their potential use in humans. Dendritic cells (DCs) play a crucial role bridging innate and adaptive immunity. Therefore, enhancing the ability of rough vaccine strains to …
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Evaluation of immunomodulatory compounds for identification of an anti-herpetic innate immune response profile
… resistant environment by stimulating the natural innate immune defenses of the vaginal mucosa. The compounds consist of evolutionarily conserved pathogen-associated molecular patterns termed toll-like receptor (TLR) agonists that are recognized by vaginally expressed TLR and elicit specific …
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Stochastic Activation of Enhancers in the Innate Immune Response by the Histone Demethylase JMJD2D
… Using the poly I:C-induced transcriptional response in MEFs as our model, we find that JMJD2d is a positive regulator of type I interferon responses. siRNA-depletion of the H3K9 demethylase JMJD2d attenuates gene activation and overexpression of JMJD2d potentiates the IFN response. We find …
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Characterizing the chelonian innate immune response through ranaviral challenge and in a natural system
Made available in DSpace on 2018-09-27T16:47:21Z (GMT). No. of bitstreams: 2 RAYL-DISSERTATION-2018.pdf: 638396271 bytes, checksum: 497be79271602193af2a8513392b4a32 (MD5) LICENSE.txt: 4208 bytes, checksum: f4eeada332d7c87f9720dd9a41a99a9e (MD5) Previous issue date: 2018-07-03
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Inosine-containing mRNA induces an innate immune response and is translated with lower efficiency
… to play a key role in modulating the host cell’s immune response to RNA. Here, we specifically study the effect of the presence of inosine in RNA by generating an inosine-containing reporter mRNA sequence. We also generated mRNA sequences that contained pseudouridine, an RNA modification known to …
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The role of the inositol phosphatase, SHIP, in the innate immune response to Salmonella Typhimurium
… cell functions and is critical for maintaining immune homeostasis. However, whether SHIP plays a role in controlling bacterial infections in vivo remained unknown. Salmonella enterica causes human salmonellosis, a disease that ranges in severity from mild gastroenteritis to severe systemic …
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