Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"innate immune recognition"”.
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Innate immune recognition by human toll-like receptor 10 and other members of the toll-like receptor 2 subfamily
Item marked as restricted to the 'UIUC Users [automated]' Group (id=2) by William Ingram (wingram2@illinois.edu) on 2011-05-25T14:42:13Z Item is restricted until 2013-05-25T14:41:28Z
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Immune Recognition of Self Nucleic Acids Driven By Endogenous Antimicrobial Peptides: Role In Autoimmunity
Innate immune recognition of extracellular host-derived self-DNA and self-RNA is prevented by endosomal seclusion of the Toll-like receptors (TLRs) in the dendritic cells (DCs). However, in psoriasis plasmacytoid dendritic cells have been found to be able to sense self-DNA molecules in complex with …
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Mechanism of Ubiquitin Induced Activation of RIG-I Like Receptors in Antiviral Innate Immunity
The innate immune response is the first line of defense against viral infections. Innate immune recognition is mediated by a set of host pattern recognition receptors that can recognize pathogen associated molecular patterns, and trigger the expression of immune response genes. Two proteins of the …
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Characterisation of surfactant protein a as a novel prophylactic means against oncogenic HPV infections
… identified surfactant protein A (SP-A), an innate immune opsonin, as a novel molecule capable of recognising HPV16 pseudovirions (HPV16-PsVs) with functional consequences for reduced infection in a murine cervicovaginal HPV challenge model. Building on these findings, our aim was to assess …
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The Role of Bacterial Amyloids In Regulating Gastrointestinal Homeostasis
… The focus of the current studies centered on the innate immune recognition of curli fibers by cells of the gastrointestinal tract and how that contributes to gastrointestinal homeostasis. In the first phase of our studies, utilizing intestinal epithelial cells polarized on semi-permeable tissue …
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Platelets and their immunomodulatory roles during Streptococcus pyogenes infection
… factor that can interact with many cells of the immune system. One of the smallest and most rapidly responding cells in our bloodstream are platelets and they are a main focus for the studies presented in this thesis and have been investigated. The overall aim of this thesis was to delineate and …
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The Impact of Candida albicans Glycogen on Fitness, Virulence and Host Response
… metabolism and physiology to cope with host immune surveillance and to counteract host-imposed constraints such as glucose limitation. Although largely unexplored in C. albicans, the glycogen metabolism pathway is a vital carbon assimilation and utilization system shown to be metabolically …
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Defining the mechanisms of microbial sensing among members of the toll-like receptor 2 sub-family
As pattern recognition receptors of the innate immune system, Toll-like receptors (TLRs) sense microbial components and mediate cell activation leading to protective inflammatory responses. TLRs are type-1 transmembrane receptors that are activated by forming dimers; an event driven by the …