Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 748 for “"innate immune"”.
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Novel innate immune functions of saliva
The innate immune system in humans has succeeded in developing numerous mechanisms against the injurious effects of bacteria, along with their toxins as a result of several thousand years of co-evolution. The oral mucosal surface represents such a unique environment, where despite being constantly …
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Senescence and the Innate Immune System
… function. Senescent cells are removed by the innate immune system, including natural killer (NK) cells, during normal embryonic development and healthy wound healing. Since eradication of senescent cells in mice leads to resistance against age-related disorders and functional restoration, one …
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Host modulation of excessive innate immune responses
A fundamental role of the innate immune system is to elicit a proper response against both invading pathogens and tissue damage or danger signals. Although the innate immune system often is successful in eliminating danger, an excessive host-response can result in severe tissue injury. Factors that …
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Determinants of innate immune responses to mycobacteria
Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers. The type and magnitude of innate responses to mycobacteria may determine the …
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Innate Immune Sensing and Signaling of Cytosolic DNA
… of invading microbial pathogens and triggers innate immune responses including the production of type-I interferons (IFNs). Endogenous DNA that is inappropriately cleared can also accumulate in cytosol and drive pathological inflammation and autoimmune diseases such as systemic lupus …
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Haemophilus influenzae adhesins and the innate immune response
… influenzae adhesins and their interactions with innate defense mechanisms. Vitronectin is a glycoprotein that regulates the terminal pathway of the complement system by inhibiting the membrane attack complex. We demonstrate that Haemophilus influenzae surface fibrils (Hsf) may increase the …
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Imaging innate immune cell behaviour in lymphoid organs
Innate immune cells generate the early host response to infection and tissue injury. Neutrophils are rapidly recruited from circulation to inflammatory tissues for pathogen killing. Type 2 innate lymphoid cells (ILC2s) mediate early responses to helminths and allergens via cytokine production. …
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Regulation of innate immune responses to Leishmania braziliensis infection
… present dissertation was aimed at studying the immune processes that take place during Lb infection. Our results have revealed three unique features of Lb infection. First, using a mouse model we showed that DCs can efficiently recognize, process and present parasite antigens to CD4+ T, cells …
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Structural and Biochemical Studies of the Innate Immune Pathway
Investigating the biochemical properties of the IRAK-4 DD led to a series of molecular recognition experiments with MyD88. In vitro transcription and translation pull-down experiments performed with IRAK-4 DD and MyD88 suggest that the ID of MyD88 might mediate this interaction.
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Mechanisms of phage detection by bacterial innate immune proteins
… As a result, bacteria have evolved diverse immune mechanisms to protect themselves from phage infection, such as restriction modification, CRISPR-Cas, and abortive infection (Abi) systems. Because Abi systems function through killing infected cells to protect the bacterial population, they …
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Innate Immune Responses in the Alternaria-Dendritic Cell Interaction
… components of the spore cell wall to stimulate innate immune responses. We found that BMDCs were highly sensitive to A. alternata spores, chitin and the major allergen Alt a 1. Following stimulation with these molecules, the expression of MHC II and other co-stimulators, like CD40, CD86, and …
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Dominant Suppression of Early Innate Immune Mechanisms by Yersinia pestis
Disease progression of primary pneumonic plague is biphasic, consisting of a pre-inflammatory and a pro-inflammatory phase. Most lung pathogens induce a measureable inflammatory response within a few hours of infection, but <italic>Yersinia pestis</italic> is strikingly different: the first 36 …
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Molecular Mechanisms Underlying Innate Immune Kinase TBK1-Driven Oncogenic Transformation
An essential kinase in innate immune signaling, TBK1 couples pathogen surveillance to induction of host defense mechanisms. The pathological activation of TBK1 in cancer can overcome programmed cell death cues, enabling cells to survive oncogenic stress. The mechanistic basis of TBK1 prosurvival …
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Disruption of Dna Polymerase Zeta Promotes An Innate Immune Response
… that loss of pol ζ promotes activation of an innate immune response.</p> <p><em>Rev3l </em>knockout MEFs had over 1000 genes that were either upregulated or downregulated more than 4-fold. Importantly, this revealed that loss of <em>Rev3l</em>induced an increase in expression of known …
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Paleovirological Analyses of Endogenous Retroviruses and Host Innate Immune Effectors
<p>About 8 and 10 percent of the human and mouse genomes, respectively, are comprised of sequences of retroviral origin. Occasional infection of germ line can lead to integrated retroviral genomes being vertically inherited as host alleles. During thousands to millions of years, some of these …
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An innate immune response to DNA damage in prostate cancer
… in solid tumors characterised by STING mediated immune signalling due to abnormal DNA as a result of loss of DNA repair mechanisms. This subtype is characterised by activation of cytokines, such as CXCL10, which attract lymphocytic infiltration and up regulate immune checkpointing genes like …
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Neuronal Regulation of the Innate Immune Response in Caenorhabditis elegans
<p>The innate immune system is the front line of host defense against microbial infections, but its rapid and uncontrolled activation elicits microbicidal mechanisms that have deleterious effects. Increasing evidence indicates that the metazoan nervous system, which responds to stimuli originating …
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Designing 3D Wireframe DNA Nanoparticles for Programmable Innate Immune Activation
… However, an understanding of how the immune system responds to wireframe DNA nanostructures is currently lacking. Furthermore, it is unclear how controllable design parameters such as scaffold sequence, nanoparticle geometry, or ligand organization influence immune activation. In my …
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Understanding the Effect of BVDV on Innate Immune Response of Neutrophils
… targeting antigen presenting cells, adaptive immune system cells and cytokine gene expression. However, very little research has been done to determine the effect of BVDV on neutrophils. Neutrophils are one of the most abundant while blood cells (WBC) in the peripheral blood, which play a …
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Immunomodulatory effects exerted by Lactobacillus salivarius strains on innate immune cells
… health status of their consumers. Modulation of immune responses is a plausible mechanism underlying these beneficial effects. The aim of this thesis was to investigate the effect of 33 Lactobacillus salivarius strains on the production of inflammatory cytokines from a variety of human and mouse …
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