Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 61 for “"innate and adaptive immunity"”.
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Equine innate and adaptive immunity to viral infections
Activation of innate immunity through Toll-like receptor (TLR) signaling can also enhance antigen-specific adaptive immunity. TLR9 is an endosomal receptor for unmethylated bacterial and viral cytosine-phosphate-guanine DNA (CpG-DNA). West Nile virus (WNV) infection may result in meningitis and …
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Evading Innate and Adaptive Immunity During Adenovirus Cell Entry
… surface upon binding to both the coxsackievirus and adenovirus receptor and α<sub>v</sub> integrins. This uncoating event leads to the exposure of the capsid membrane lytic protein VI. Using the cytosolic protein galectin-3 (gal3) as a marker of membrane rupture, we demonstrate that Ad5 membrane …
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IL-27 AND THE REGULATION OF INNATE AND ADAPTIVE IMMUNITY DURING TOXOPLASMOSIS
… response to the pathogen Toxoplasma gondii, and the majority of the studies on IL-27 during this infection have focused on its ability to limit T cell responses. The basis for this suppressive activity is unclear, but it was proposed that the ability of IL-27 to promote T cell expression of …
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Restriction-Modification and CRISPR-Cas Systems: Cooperation Between Innate and Adaptive Immunity in Prokaryotes
… or simply phages) that can infect and kill them. Restriction-modification (RM) systems represent one such strategy. Generally, these systems provide defense by coordinating the activities of two distinct enzymes: a restriction endonuclease and a methyltransferase. Both enzymes …
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Of Mice and Men: Studying Innate and Adaptive Immunity Against the Epstein-Barr Virus
… be observed as B cell transformation in vitro and lymphomas as well as epithelial cancers in vivo, but most immunocompetent individuals control EBV infection successfully without the occurrence of disease. Cells of the innate immune system act in synergy to provide a first line of defense …
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Single cell landscape of innate and adaptive immunity in metastatic melanoma treated with immunotherapy
… (ICIs) have revolutionized the care for cancer and extended survival for many patients. While ICIs have shown astonishing clinical benefits, less than 50% of patients experience a durable response. To find better biomarkers for ICI response and understand the diverse cellular players in the …
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Induction of Innate and Adaptive Immunity In Vivo by Selective Antibody Targeting of Poly dA:dT and Antigen to Dendritic Cells
… cells (DCs) have been shown to be efficient and specialized in antigen presentation, but innate stimuli have not been selectively delivered to determine if these cells alone can integrate innate and adaptive immunity in vivo. Here we illustrate a novel method using expressed protein ligation …
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The role of the atypical chemokine receptor CCX-CKR in thymocyte development and its influence on the link between innate and adaptive immunity through regulation of dendritic cell migration.
… directing cell migration both during homeostasis and immune responses has been appreciated for some time. However, the mechanisms in place to post-translationally regulate cell migration through chemokine modulation are only recently becoming clear. CCX-CKR is a receptor that can scavenge and …
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Suppression of NK cell-mediated cytotoxicity and immunoenhancement of CD40 ligand against porcine reproductive and respiratory syndrome virus
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important pathogenics affecting swine industry worldwide. PRRSV is a single-stranded and positive sense RNA virus that belongs to the family of the Arteriviridae (genus Arterivirus). PRRSV has a restricted …
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Vývoj vybraných CD znaků a jejich role ve fylogenezi imunitního systému člověka
… of human, namely CD19, CD20, CD21, CD24, CD27 and CD38 molecules. In addition, nucleotide and amino acid sequences of these molecules were compared using in silico approach. Bioinformatic databases of sequences of selected molecules at DNA, mRNA and protein level, such as GeneBank, NCBI BLAST, …
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Human neutrophils generate extracellular vesicles that modulate their functional responses
Neutrophils influence innate and adaptive immunity by releasing various cytokines and chemokines, by generating neutrophil extracellular traps (NETs), and by modulating their own survival. Neutrophils also produce extracellular vesicles (EVs) termed ectosomes, which influence the function of other …
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Defining The Role of Il-15 Trans-Presentation By Distinct Cell-Types During The Development and Homeostasis of Natural Killer and Invariant Natural Killer T Cells
The immuno-regulatory functions displayed by NK and iNKT cells have highlighted their importance as key lymphocytes involved in innate and adaptive immunity. Therefore, understanding the dynamics influencing the generation of NK and iNKT cells is extremely important. IL-15 has been shown to provide …
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Platelets : their exploitation and elimination
… to the essential functions of haemostasis and thrombosis. However, it has become clear in the last decade that platelets play significant roles in both innate and adaptive immunity, inflammatory responses including leukocyte migration, tissue regeneration and angiogenesis. Parallelling the …
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Platelets : their exploitation and elimination
… to the essential functions of haemostasis and thrombosis. However, it has become clear in the last decade that platelets play significant roles in both innate and adaptive immunity, inflammatory responses including leukocyte migration, tissue regeneration and angiogenesis. Parallelling the …
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NAD+-DEPENDENT SIRT1 REPROGRAMS CD11C+ DENDRITIC CELLS AND CD4+ T CELLS TO CONTROL IMMUNE POLARITY DURING SEPSIS
There is a deficit in the understanding of immune response polarity during sepsis and acute inflammation. Skewing of the polarity can lead to immunometabolic dysfunction, organ failure, and death from sepsis. Sirtuins are known regulators of immunity and have been shown to play a pivotal role in …
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Reconstitution of Munc18-Dependent Mast Cell Degranulation
… in the body, mediated by release of histamine and other pharmacologically active substances. Although offering essential protection in innate and adaptive immunity, mast cells are also essential to the progression of inflammatory diseases, including allergy and asthma, (Theoharides et al., …
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Epidermicin NI01 and human β-defensin 2 as modulators of macrophage subset responses
Antimicrobial peptides (AMPs) and host defence peptides (HDPs) have been extensively investigated for their antimicrobial activity and evidence suggests that they can also modulate the host immune system. However, little is known about their effects on macrophages, a key cell population in …
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BOTH EFFECTOR AND INHIBITORY IMMUNE MECHANISMS ARE AMPLIFIED IN CASTRATION-RESISTANT PROSTATE CANCER
Immune function is modulated by androgen ablation therapy for prostate cancer. Androgen ablation leads to apoptosis of primary prostate tumor and transient potentiation of immune function. However, immune inhibitory mechanisms employed by the tumor eventually prevent prolonged anti-tumor immunity. …
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Sexual immune dimorphism in ecological context : the impact of estrogen on human immune function and development of bacteria killing assay.
… to differences in immune function between males and females, shaped by hormonal, genetic, behavioral, and evolutionary factors. This dissertation examines these differences through an ecological and evolutionary lens, focusing on the role of estrogen in immune modulation and the development of a …
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Dendritic cell regulation of immunity to Leishmania donovani
Dendritic cells lie at the interface of innate and adaptive immunity, critically contributing to the generation of an antigen-specific immune response. Although the mechanisms by which they initiate protective immunity are well characterised, their precise contribution to the subsequent regulation …
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