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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1760 for “"innate"”.
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INNATE
I often think of life as a tight rope stretching across an expanse. Our inner strength enables us to walk forward across it. When this fails us, we fall. But in those moments when we prevail, we soar and float as though weightless and timeless. As a gymnast I learned that control of one's …
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Regulatory Mechanisms in Innate Immunity
Innate immunity is the frontline for the host to defend against infections. This process entails the cooperation among pathogen recognition receptors, adaptor proteins, kinases, and transcription factors that elicit the production of effector cytokines. As an important transcription factor, IRF5 …
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Innate memory to bacterial infection
The innate lymphoid cells (ILCs) ILC1, ILC2, and ILC3, which also includes the natural killer (NK) cells are important regulators and first line responder during pathogen invasion. The role of ILCs was evaluated using FACS sorting, cytokine production and surface markers analysis, cell depletion, …
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Novel innate immune functions of saliva
The innate immune system in humans has succeeded in developing numerous mechanisms against the injurious effects of bacteria, along with their toxins as a result of several thousand years of co-evolution. The oral mucosal surface represents such a unique environment, where despite being constantly …
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The innate response to fungal infection
… In the response to fungal pathogens, the innate immune system recognises a series of specific PAMPs via the Dectin-1 and TLR2 receptors, ultimately resulting in pro and anti-inflammatory cytokine production.<br/>Following Dectin-1 activation, I show that blocking SYK activity with SYK …
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Human Cellular Genetics of Innate Immunity
… type I interferon response is a key part of the innate immune system, responding to infection and inducing an antiviral intracellular state. While there is known to be variability in this signalling pathway between individuals, alongside cell-to-cell heterogeneity in a genetically identical cell …
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Senescence and the Innate Immune System
… function. Senescent cells are removed by the innate immune system, including natural killer (NK) cells, during normal embryonic development and healthy wound healing. Since eradication of senescent cells in mice leads to resistance against age-related disorders and functional restoration, one …
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Adipocytes and Innate Immunity In Systemic Sclerosis
<p>Systemic sclerosis (SSc; scleroderma) is a chronic systemic autoimmune and connective tissue disorder characterized by vasculopathy, autoimmune phenomena, and widespread fibrosis. Skin thickening and tightening is the cardinal feature of SSc and is responsible, in part, for the considerable …
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Host modulation of excessive innate immune responses
A fundamental role of the innate immune system is to elicit a proper response against both invading pathogens and tissue damage or danger signals. Although the innate immune system often is successful in eliminating danger, an excessive host-response can result in severe tissue injury. Factors that …
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Ribonuclease H2, RNA:DNA hybrids and innate immunity
The activation of the innate immune system is the first line of host defence against infection. Nucleic acids can potently stimulate this response and trigger a series of signalling cascades leading to cytokine production and the establishment of an inflammatory state. Mutations in genes encoding …
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Group 2 innate lymphoid cells and reproduction
… Recent findings showed that tissue-resident innate lymphoid cells (ILCs) are crucial regulators of both physiology and pathology of the tissues they populate. Uterine natural killer (uNK) cells are a subtype of ILCs known to regulate trophoblast invasion, uterine vascular adaptation to …
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Determinants of innate immune responses to mycobacteria
Innate cells such as macrophages, monocytes, myeloid dendritic cells and granulocytes recognise mycobacteria and initiate immune responses such as phagocytosis, cytokine production and expression of maturation markers. The type and magnitude of innate responses to mycobacteria may determine the …
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Equine innate and adaptive immunity to viral infections
Activation of innate immunity through Toll-like receptor (TLR) signaling can also enhance antigen-specific adaptive immunity. TLR9 is an endosomal receptor for unmethylated bacterial and viral cytosine-phosphate-guanine DNA (CpG-DNA). West Nile virus (WNV) infection may result in meningitis and …
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Innate and humoral immune responses to HIV-1
… we investigate aspects of both the cellular innate and adaptive humoral arms of the immune system in response to HIV-1 infection and vaccination with designed epitope-scaffold immunogens. First, we review the anti-viral contributions from natural killer (NK) cells, focusing on NK cell …
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Innate Immune Sensing and Signaling of Cytosolic DNA
… of invading microbial pathogens and triggers innate immune responses including the production of type-I interferons (IFNs). Endogenous DNA that is inappropriately cleared can also accumulate in cytosol and drive pathological inflammation and autoimmune diseases such as systemic lupus …
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The Role of LIFR Signaling in Innate Immunity
… are an abundant and key population in the innate immune response that originates in the BM, and they circulate to monitor the periphery. Monocytes are composed of many subsets that have essential and specific functions, including swift egress from the BM, production of pro-inflammatory …
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Activation of innate immunity during systemic Candida infections
Contains fulltext : 144023.pdf (Publisher’s version ) (Open Access)
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THE ROLE OF HYALURONAN IN INNATE INTESTINAL DEFENSE
… for small, fragmented HA polymers in initiating innate defense responses through interaction with innate molecular pattern recognition receptors such as TLR4. It was hypothesized that hyaluronan from human breast milk enhances innate intestinal epithelial antimicrobial defense. Synthetically …
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Haemophilus influenzae adhesins and the innate immune response
… influenzae adhesins and their interactions with innate defense mechanisms. Vitronectin is a glycoprotein that regulates the terminal pathway of the complement system by inhibiting the membrane attack complex. We demonstrate that Haemophilus influenzae surface fibrils (Hsf) may increase the …
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