Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"injectable hydrogel"”.
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Development of an Injectable Hydrogel Platform to Capture and Eradicate Glioblastoma Cells with Chemical and Physical Stimuli
… removal of the primary GBM tumor mass, an injectable hydrogel can be dispensed into the resection cavity for crosslinking in situ. A combination of chemical and physical cues can then induce the migration of the residual GBM/GSCs into the injectable hydrogel to localize and concentrate the …
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Bridging the lesioned spinal cord using hydrogel
… 2 C. Bridging cavity using biomaterials 3 D. Injectable hydrogel for contusive injury model 4 E. Aims of Study 5 II. MATERIALS AND METHODS 6 1. Animal and surgical procedures 6 2. Poly (phosphazene) hydrogel injection 6 3. Tissue processing 6 4. Immunohistochemistry 7 5. Three dimensional …
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Biomaterials for protection and repair of the central nervous system
An injectable hydrogel for controlled release of methylprednisolone was designed based on the inflammatory response during acute spinal cord injury. The gel is injectable through a small gauge needle, cross-links under physiological conditions, and releases methylprednisolone over a time period on …
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Synthetic Degradable Polymer Systems for Drug Delivery
… 2 describes the study of a thermo-responsive injectable hydrogel for the controlled release of GSK3787, a potential disease-modifying therapeutic for OA. The hydrogel was prepared from methacrylate-capped poly(caprolactone-co-lactide)- poly(ethylene glycol)-poly(caprolactone-co-lactide) …
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Injectable hydrogels for the improved delivery of treatments in spinal cord injury
… address this inadequacy, we designed a versatile injectable hydrogel platform and investigated its utility for local delivery of biomacromolecules to SCI contusion lesions. To develop this hydrogel platform we synthesized a library of different tri-thiol-functionalized ethoxylated polyol esters …
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Alginate-based Hydrogels for Central Nervous System Tissue Regeneration
… that alginate polymerizes in vivo, forming a hydrogel, and that it does not elicit any inflammatory response following injection. Our data show that alginate, alone or modified, is a suitable biomaterial to promote in vitro differentiation of pluripotent cells toward neural fates. Moreover, it …
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Development of Cellulose-Based, Semi-Interpenetrating Network Hydrogels as Tissue-Adhesive, Thermoresponsive, Injectable Implants
… Cellulose-Based, Semi-Interpenetrating Network Hydrogels as Tissue-Adhesive, Thermoresponsive, Injectable Implants</strong></p> <p>Hydrogels are three-dimensional polymer networks with high water content and tunable mechanical properties, which have been widely investigated as replacements for …
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Chitosan/Ellagic Acid Composite Materials for Local Cancer Therapy
… the delivery method and efficacy, chitosan based injectable hydrogel was developed for a local administration of ellagic acid to avoid surgical complications. Studies of the chitosan gel were performed with regard to chemical structure, surface morphology, viscoelasticity, release profile, and …