Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"inhibitory synapse"”.
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Interaction of Quantal Inhibitory and Excitatory Neurotransmission in Regulation of Synaptic Homeostasis via Molecular Signaling
… is undeniably shaped by individual neurons and synapses. The type of synapse between any two given neurons determines the reliability, speed, and strength of signal transfer. Therefore, studying the organization and signaling capacity of the variety of synapses present in our nervous system is …
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Functional genomic and transcriptomic tools for spatial and dynamic phenotypes
… differential modulators of excitatory and inhibitory synapse formation, implicating diverse cellular pathways in this process. To increase the throughput of these optical pooled screens, we also built a fluidics platform for automated in situ sequencing. Finally, we leveraged retroviral …
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The Effects of Δ9-tetrahydrocannabinol (THC) on development and hyperekplexia in embryonic zebrafish model
… THC is able to affect both the excitatory and inhibitory synapses. Hyperekplexia is an upper motor neuron disease characterized by hypertonia and exaggerated startle response. In Hyperekplexia, there is a decrease in inhibitory synapse caused by a loss of glycine receptors. Because previous …
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Synaptic Protein Profiling in the Mammalian Brain
… each receiving thousands of synaptic inputs. Synapses are specified in part through the precise localization of synaptic proteins, yet it has not previously been possible to analyze the protein content of an individual class of synapses. In order to achieve this, we have used the BAC …
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Visualizing inhibitory and excitatory synapse dynamics In vivo
… we now know that even in the mature brain inhibitory or excitatory connections can be made and broken, modifying the information flow within a circuit by enabling or removing specific information channels. However, the properties of inhibitory and excitatory synapse dynamics are not well …
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Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo
… memory. Removal or addition of excitatory and inhibitory synaptic inputs onto a neuron can affect their relative influence on excitation in specific dendritic segments, and ultimately regulate neuronal firing. However, the structural dynamics of excitatory and inhibitory synapses in vivo, and …
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The neural cell adhesion molecule 2 (NCAM2) promotes excitatory synapse formation through increasing insulin and insulin-like growth factor 1 receptor signaling
… disability. NCAM2 is enriched at excitatory synapses and is involved in synapse maturation and maintenance. The role of NCAM2 in the regulation of synaptogenesis, however, remains poorly understood. We hypothesized that NCAM2 promotes synaptogenesis through regulating insulin and IGF1 …
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Mechanisms underlying neural circuit remodeling in Toxoplasma gondii infection
… rich with fast-spiking parvalbumin perisomatic synapses, a type of GABAergic synapse whose dysfunction has been implicated in epilepsy and schizophrenia. By employing a range of visualization techniques to assess cell-to-cell connectivity and neuron-glia interactions (including …
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Synapse Dysfunction Induced by Autism Spectrum Disorder Associated Shank3 Mutations
… investigations into understanding the roles of synapse dysfunction in the pathogenesis of ASD. Shank3 is a postsynaptic scaffolding protein that is essential to regulating both the function and structure of excitatory synapses and Shank3 genetic mutations have been described in people affected …
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The effects of anaesthetic agents on synapses of lymnaea stagnalis (L.)
… GABA and Glutamate can be both excitatory and inhibitory, and injection of GABA into Lymnaea has been shown to result in behavioural changes in feeding, locomotion, escape reactions, male mating and respiration. Injection of Na-thiopentone into the whole animal was carried out in this …