Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"inhibitory receptors"”.
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NK Cell Function and Tumor Resistance in Mice Transgenic for Antibody to NK Inhibitory Receptors
… system, are implicated in tumor surveillance. Inhibitory Ly49 receptors determine the specificity of murine NK cells by recognizing of MHC class I molecules expressed on the target cell. This allows the transmission of inhibitory signals through intracellular signals to block NK cytotoxicity. …
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Modulation of Ly49A+ Natural Killer Cell Licensing by Major Histocompatibility Complex Class I Alleles
… bone marrow. This reactivity is mediated by inhibitory receptors for MHC class I that block the ability of activation receptors to stimulate NK cells. Since many NK cells lack receptors that recognize self-MHC, the inhibitory receptors also mediate a second function, termed NK cell licensing, …
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Role Of Il-27 And Tcr Stimulation In Inhibitory Receptor Expression
… on the ability of IL-27 to promote expression of inhibitory receptors on T cells. The studies presented here establish that TCR and cytokines have distinct and complementary roles in promoting inhibitory receptor expression. In vitro, IL-27, type I IFN, and IFN-g induced expression of PD-L1 and …
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PD-1 AND PD-1 LIGAND REGULATION OF NATURAL ANTIBODY SPECIFICITIES AND THE ADAPTIVE RESPONSE TO PNEUMOCOCCAL POLYSACCHARIDES
Interest in immuno-inhibitory receptors and their ligands has increased in the past three decades. Programmed cell death-1 (PD-1) is a surface-expressed receptor of the B7/CD28 superfamily and the subject of considerable study since its discovery in 1992 [1]. The available literature lacks an …
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Understanding T cells in type 1 diabetes: a role for c-Maf and characterization of intracellular signaling following engagement of transgenic Ly49A.
… responsible for suppression of T cells by the inhibitory receptor Ly49A. It is not clear why development of protective Th2 cells is poor in T1D. c-Maf transactivates the <italic>IL-4</italic> gene promoting Th2 cell development; therefore abnormalities in c-Maf may contribute to reduced IL-4 …
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Tranexamic Acid Modulation of Excitatory and Inhibitory Amino Acid Receptors: A Potential Mechanism for Postoperative Seizures
… by shifting the balance between excitatory and inhibitory neurotransmission. Specifically, TXA could promote hyperexcitability by enhancing the function of excitatory amino acid receptors (NMDA, AMPA, and kainate receptors). Alternatively, TXA could cause disinhibition by reducing the activity …
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Single-cell technologies for monitoring interactions between immune cells
… of NK cells with distinct repertoires of inhibitory receptors. Inhibitory receptors prevent NK cells from attacking healthy cells, and their expression can confer NK cells with increased functional activity in a process known as "licensing". We show that despite forming prolonged contacts …
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The role of uterine natural killer cell-inhibition in pregnancy
… NK-cell activity upon the binding of their inhibitory receptors to self-ligands. Although NK-cell education is predictable and measurable in the laboratory, its biological significance is unknown. This thesis shows that the inhibitory NK cell receptor NKG2A protects against the hypertensive …
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USING UNSUPERVISED LEARNING TECHNIQUES TO UNDERSTAND CD8+ T CELL DIFFERENTIATION DURING VIRAL INFECTION AND TUMOR DEVELOPMENT
… CD8+ tumor infiltrating lymphocytes had reduced inhibitory receptors expression but lower levels of cytokine production. Therefore, these results demonstrate memory CD8+ T cells from latent infection occupy an intermediate differentiation space, and autoimmunity increases antitumor response.
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Therapeutic Strategies to Target LILRB Receptors on Myeloid Cells for Cancer Immunotherapy
… in cancer treatment. LILRB3 and LILRB4, immune inhibitory receptors containing tyrosine-based inhibitory motifs (ITIMs), are expressed solely on myeloid cells. However, it is unknown whether LILRB3 is a critical checkpoint receptor to support the activity of immunosuppressive myeloid cells, and …
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IL-27 AND THE REGULATION OF INNATE AND ADAPTIVE IMMUNITY DURING TOXOPLASMOSIS
… ability of IL-27 to promote T cell expression of inhibitory receptors (such as TIGIT and PD-L1) contributed to this activity. In chapter 2, the role of TIGIT during infection was assessed and indicated it was not a critical mediator of the suppressive effects of IL-27. In chapter 3, the impact of …
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The Role of Aerobic Glycolysis in the Resting Human Brain
… with a balanced density of excitatory and inhibitory receptors. Taken together, these results demonstrate the functional significance of resting aerobic glycolysis and its modulation by transient functional activity. These data provide supporting evidence for the synaptic homeostasis …
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Efficacy of Dual Cd19-Cd79B Car In B-Cell Malignancies
… as the phenotype and expression of various inhibitory receptors were similar to untransduced and CD19 CAR-transduced T cells. In summary, dual targeting of CD19 and CD79b could provide a feasible strategy to minimize antigen escape and improve v the efficacy of CAR T treatment for patients …
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Inhibitory synapses are repeatedly assembled and removed at persistent sites in vivo
… memory. Removal or addition of excitatory and inhibitory synaptic inputs onto a neuron can affect their relative influence on excitation in specific dendritic segments, and ultimately regulate neuronal firing. However, the structural dynamics of excitatory and inhibitory synapses in vivo, and …
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CD4+ T cells in the pathogenesis of visceral leishmaniasis
… CD4+ T cell and macrophage populations expressed inhibitory receptors and ligands, respectively. Blocking PD-L2 led to a significant decrease in parasite burden revealing a pathogenic role for the PD-1 pathway in chronic visceral leishmaniasis. Inhibitory molecules are possible targets for …
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The Multifaceted Contribution of Natural Killer Cells During Herpes Simplex Type-1 Viral Infection.
… of signals received through both activating and inhibitory receptors. During the course of a herpes simplex virus type-1 (HSV-1) infection, NK cells can influence host susceptibility to infection with severe infections occurring in individuals with genetic defects in the NK cell response. In …
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Selezione e processazione di cellule Natural Killer da donatore aploidentico "KIR-ligand" incompatibile per l'immunoterapia adottiva di pazienti con Leucemia Acuta Mieloblastica ad alto rischio
… killer (NK) cells is regulated by activating and inhibitory receptors, termed killer immunoglobulin-like receptors (KIRs). In haploidentical T-cell depleted transplantation the donor/recipient KIR mismatch significantly impacts on NK-mediated tumor cell killing, particularly in acute myeloid …
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Determining stromal evolution in response to immune checkpoint inhibition
… genes. Alongside a decrease of immune-inhibitory receptors, we detected an increase in co-stimulatory molecules in CAFs from tumours responding to ICI. Our data indicates that these changes are driven by inflammatory mediators including IFN-γ, released by re-activated tumour …
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Importance of specific NK cell subsets for antitumor immunity in HPV+ cancers
… immunity. Among the multitude of activation and inhibitory receptors on immune cells, HLA-DR is recognized as an important activation marker on both CD8 T and NK cells. Literature studies refer to HLA-DR+ NK cells as pre-mNK. Data from our preclinical HPV tumor models demonstrated that induction …
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Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
… loss of Tex, reduced expression of inhibitory receptors including PD-1, and a pronounced decrease in terminally differentiated subsets of Tex cells. Simultaneous gene expression and epigenetic profiling revealed a critical role for TOX in ensuring ongoing chromatin accessibility and …
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