Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 30 for “"inhibitory neurons"”.
-
Dynamics of a fully stochastic discretized neuronal model with excitatory and inhibitory neurons
… of discretized integrate-and-fire excitatory neurons where synapses are failure-prone. It was shown that this model exhibits different metastable phases of asynchronous and synchronous behavior, since the model limits on a mean-field deterministic system with multiple attractors. Our work …
-
Visual cortical plasticity : the role of parvalbumin expressing inhibitory neurons and abnormalities in models of neurodevelopmental disorders
The roles played by cortical inhibitory neurons in experience-dependent plasticity and learning are not well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) GABAergic neurons in two forms of experience-dependent modification of primary visual cortex (V1) in adult …
-
Modulation of Excitatory and Inhibitory Neuronal Balance Through Regulation of Ptf1a by Factors Binding to Zinc Finger and POU Motifs
… on a delicate balance between excitatory and inhibitory neurons. Transcription factors of the basic helix-loop-helix (bHLH) family have been shown to be particularly important in generating the correct numbers of these neurons during development. One of these, Ptf1a, is required in the …
-
Examining the Dynamics of Biologically Inspired Systems Far From Equilibrium
… characterized its behavior as the fraction of inhibitory neurons was changed. At low fractions of inhibitory neurons we observed epileptic-like behavior in the system, as well as extended tails in the avalanche strength and duration distributions, which dominate the system in this regime. We …
-
Investigating the Transcriptional Regulation of PTF1A and the Function of PRDM13 to Specify Dorsal Spinal Interneurons
… expression is required for specification of the inhibitory fate while silencing the excitatory fate in the neural tube. Previous studies from our lab determined that PTF1A directly activates the inhibitory neuron lineage specific genes to direct neural progenitors towards an inhibitory neuronal …
-
Prefrontal coding of naturalistic working memory: Mechanisms during normal maintenance and modelled disease
… LPFC (areas 9/46 & 8a). During this task, single neurons are spatially selective for remembered target locations and neural populations contain large amounts of information about the target location over the duration of the task. Neural coding for WM is robust and distinct from signals related to …
-
Distinct roles for inhibitory neuron subtypes in cortical circuits : an examination of their structure, function, and connectivity
Parvalbumin-containing (PV+) neurons and somatostatin-containing (SOM+) neurons are two key cortical inhibitory cell classes that are poised to play distinct computational roles in cortical circuits: PV+ neurons form synapses on the perisomatic region near the spike initiation zone of target cells, …
-
Activity-Dependent Regulation of Inhibition from Different Inhibitory Subtypes
… adaptations occur to maintain firing rate of neurons at a particular set-point. To better understand homeostatic plasticity at the network level, one must understand the activity-dependent adaptations that occur in the different neocortical cells types. To this end, I examined the regulation …
-
Hippocampal microcircuits for social memory specification
… inhibition. Both the inhibition of GABAergic inhibitory neurons in CA2 and reduced activity of excitatory neurons by ablation of oxytocin receptors in the dCA2 to vCA1 microcircuits impair social memory specification. These results suggest that the vCA1 and the multiple feed-forward inhibition …
-
Using Hi-Spots to investigate in vitro network dysfunction in Cysteine String Protein ? knockout mice
… anatomically synaptically-interconnected neurons, astroglia and microglia. This CNS analogue of brain tissue provides for the emergence of a co-ordinated excitatory and inhibitory network, demonstrating a maturing pattern of activity involving single spikes developing into bursting …
-
Inhibition stabilized network model in the primary visual cortex
… studied neural networks of both excitatory and inhibitory populations with inhibition stabilized network (ISN) models. In ISN models, the recurrent excitatory connections are so strong that the excitatory sub-network is unstable if the inhibitory firing rate is fixed; however, the entire network …
-
Cholinergic Control of Cortical Circuit Activity
<p>Cholinergic neurons of the basal forebrain send extensive projections to all regions of the neocortex and are critically involved in a diverse array of cognitive functions, including sensation, attention and learning. Cholinergic signaling also plays a crucial role in the moment-to-moment …
-
Characterization of Tyrosine Hydroxylase-Positive Neurons Projections from the Paraventricular Nucleus of Hypothalamus to Hindbrain Autonomic Regulatory Centers
… that contains complex type of excitatory or inhibitory neurons. Tyrosine hydroxylase (TH)-positive neurons in the hypothalamus plays important role in cardiometabolic regulation; however, the anatomical projections of TH neurons in the paraventricular nucleus hypothalamus (PVN) to key …
-
Neuronal PAS Domain 1 Protein and Its Hypothetical Relationship to Autism
… an expression pattern largely restricted to inhibitory neurons in the aforementioned brain regions, as well as localized expression in the subgranular region of the dentate gyrus. NPAS1 and NPAS3 transcription factors are paralogues that have evolved from the Drosophila gene Trachealess. …
-
Engineering novel neuronal circuits using HI-PSCS derived neurons and microglia
… the cell population and functionality of neurons and microglia in culture and on a microelectrode array (MEA). The Real Time Quantitative Reverse Transcription (qRT-PCR) showed that we differentiated into a mixture of excitatory and inhibitory neurons that belong to the cortex. This was …
-
Inhibitory Control of Contextual Fear Memory and Memory Specificity
… in the brain is mainly achieved by GABAergic inhibitory neurons which exert their effect by acting on multiple types of GABA receptors. In this dissertation, I examined the roles of specific types of GABAergic neurons and GABA receptors in learning and memory. The study consists of three major …
-
Accelerated fibre microendoscopy techniques for in-vivo applications
… observations of cell bodies and processes of inhibitory neurons within deep layers of the visual cortex and hippocampus of anesthetised mice. <br/><br/>Future advancements will strongly rely on the development of new fibre types directly optimised for the purposes of holographic endoscopy. …
-
The development, cytoarchitecture, and circuitry of the ventral lateral geniculate nucleus
… vLGNi are also composed of diverse subtypes of neurons. In vLGNe, we discovered at least six transcriptionally distinct subtypes of inhibitory neurons that are distributed into distinct adjacent sublaminae. Using trans‐synaptic viral tracing and ex vivo electrophysiology, we found that cells in …
-
Characterizing Effects of Sphingosine-1-Phosphate Receptor 1 Activation in Subtypes of Central Amygdala Neurons and Effects of Prenatal Methadone Exposure on Motor Cortex Neurons in Mice
… CeA is made up of a heterogenous population of neurons which form complex local and long-range circuits. The central lateral amygdala (CeL) consists of two major populations of inhibitory neurons identified by expression of the peptides somatostatin (Sst) and protein kinase Cδ (PKCδ). Sst …
-
Unsupervised tracking and automated analysis of multi-population neural activity under anesthesia
… of hundreds of identified excitatory and inhibitory neurons. To address these issues, we developed a system that enables optical recording from multiple neuronal populations during extended, controlled states of anesthesia. We also built a pipeline that automates the processing of …
Page 1 of 2