Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"inhibitory interneuron"”.
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Potassium channels for high-frequency action potential generation in GABAergic interneurons of Rat Hippocampus
… of Kv channels expressed in orien-alveus (OA) interneurons in the hippocampal CA1 region, a major class of dendritic inhibitory interneuron. The main results are as follows. First, the macroscopic K+ current in OA interneurons consists mainly of a fast delayed rectifier (57 ± 5), a slow delayed …
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INTERNEURON TRANSPLANTS AS A TREATMENT FOR SEIZURES AND SOCIAL DEFICITS IN A MOUSE MODEL OF DRAVET SYNDROME
GABAergic inhibitory interneuron transplants have been shown to ameliorate seizures and epilepsy-associated behavioral deficits in several preclinical rodent models of epilepsy. These studies have generally focused on focal temporal epilepsy models, but less is understood about the efficacy of …
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Investigating the role of thalamic activity in visual cortical plasticity
… model of LTP, including the requirement of inhibitory interneuron activity but not LTP onto the classic input to layer 4 of the visual cortex. Such differences may be clarified by analyzing the dorsal lateral geniculate nucleus (dLGN) of the thalamus, which is the primary source of visual …
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The Role of Perineuronal Nets in Regulating Barrel Cortex Physiology
… action potential amplitude in fast spiking (FS) inhibitory interneurons; 3) enzymatic digestion of PNNs only mildly impac spike frequency and firing probability, but significantly reduces input resistance, and spike amplitude in FS inhibitory interneurons and 4) Perturbation of PNNs reduces the …
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Roles Of Inhibitory Interneurons In Cerebellar Cortical Processing For Oculomotor Control
… two techniques for examining the roles of interneurons in cerebellar processing. In the second, I present the results of a study of one such interneuron, the Golgi cell, which is the main type of inhibitory interneuron that regulates information flow at the input stage of the cerebellar …
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Dorsal Cochlear Nucleus Output Neurons in Young and Aged Rats
… acoustic nerve, which is modulated and shaped by inhibitory glycinergic inputs from nearby vertical cells. A number of studies in rodents suggested an age-related impairment of glycinergic neurotransmission. To access the functional impact of reduced putative glycinergic input in the central …
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Neocortical functional network development at the microscale: impairments and mechanisms in Rett Syndrome.
… suppression of parvalbumin-expressing inhibitory interneurons restored spatiotemporal spiking dynamics. Finally, human cerebral organoids did show complex topology and hub node features beyond that which could be explained by high firing rates at 180 days in vitro. To conclude, …